Gas Chromatography Solvents

Our GC solvent qualities are ideal for all gas chromatography applications. These solvents are specially developed and tested for ECD, FID and MS detection to ensure a maximum signal-to-noise ratio in the largest specified retention time range. Our solvents for headspace gas chromatography are developed specifically for the analysis of residual solvents in drug substances, excipients, and drug products according to Ph. Eur. and USP. High purity is provided by specially designed production processes for accurate, reliable and reproducible analytical results.

SupraSolv® GC Solvents Specifications

SupraSolv® solvents SupraSolv® Headspace
for analysis of residual solvents
SupraSolv® hypergrade for organic trace analysis SupraSolv®
for GC-ECD/FID
SupraSolv®
for GC-MS
Suitability Tested GC Headspace technique Electron capture detector, flame ionization detector and mass spectroscopy Electron capture detector and flame ionization detector GC-MS/MS
Descriptions Free from contaminants could possibly interfere with GC analysis by coeluting with peaks of interest in the sample Narrow specification, the highest purity, and larger retention time range; low boiling substances can be reliably detected; the permissible concentration of interference signals within the retention time range is lower Meet EPA Method 508 and the stringent demands of capillary gas chromatography; glass-distilled solvents resulting in exceptional quality and low residue levels Undergo rigorous purification procedures and assure high chemical purity; lowest impurity profile and minimal signal-to-noise ratio in specification
Specification Every residual solvent of class 1 acc. CH ≤ 1 µg/g

Every residual solvent of class 2 acc. CH ≤ 10 µg/g

Every residual solvent of class 3 acc. CH ≤ 50 µg/g

≤ 1 ng/mL compared to Tetrachloromethane GC-ECD

≤ 2 pg/mL compared to Lindane GC-ECD

≤ 2 ng/mL compared to n-Tetradecane GC-FID

≤ 2 ng/mL compared to n-Tetradecane GC-MS
3 pg/mL compared to Lindane GC-ECD

≤ 3 ng/mL compared to n-Tetradecane GC-FID
≤ 3 ng/mL compared to n-Tetradecane GC-MS
Benefits Extremely high purity resulting in a very low baseline

Microfiltered (0.2 μm)

Packaged under inert gas for longer shelf life

Meet USP, Ph. Eur. and ICH guidelines
Extremely low residual impurities

Multi-purpose grade
Very high purity

Improves column lifetime due to extremely low content of non-volatile matter

low residue levels
Very high purity

Improves column lifetime due to extremely low content of non-volatile matter
Applications Residual solvents analysis in drug substances and products acc. Ph Eur & USP Pesticide analysis

Organic residue analysis
Volatile halogenated hydrocarbons in water

Polychlorinated biphenyls (PCB) in water

Detection of Acrylamide in food

BTX analysis (Benzene, Toluene, Xylene) detection

Hydrocarbon-oil-index in water

Determination of emissions in car cockpit materials
Analysis of Dioxins and Furans (PCDD/PCDF)

Analysis of polycyclic aromatic hydrocarbons

Pesticide analysis acc. QuEChERS

Determination of phthalates in plastics

SupraSolv®solvents for gas chromatography ECD and FID

Solvent Available Pack Sizes Product Number
Acetone 1 L GL ,2.5 L GL ,4 L GL ,30 L ST 100012
Acetonitrile 1L GL ,2.5L GL 100017
tert-Butyl methyl ether 1 L GL ,2.5 L GL 101995,
Chloroform, stabilized 1 L GL ,2.5 L GL 102432
Cyclohexane 1 L GL ,2.5 L GL ,4 L GL ,10 L ST 102817
Dichloromethane, stabilized 1 L GL ,2.5 L GL ,4 L GL ,10 L ST 106054
Diethyl ether, stabilized 1 L GL ,2.5 L GL ,4 L GL 100931
N,N-Dimethylformamide 1 L GL ,2.5 L GL 110983
Ethanol 1 L GL ,2.5 L GL 102371
Ethyl acetate
1 L GL ,2.5 L GL ,4 L GL ,10 L ST,30 L ST
110972
n-Hexane 1 L GL ,2.5 L GL ,4 L GL ,10 L ST,30 L ST 104371
Isohexane 2.5 L GL 104340
Isooctane 1 L GL ,2.5 L GL 115440
Methanol 1 L GL ,2.5 L GL,4 L GL 106011
n-Pentane 1 L GL ,2.5 L GL 100882
Petroleum benzine (40 - 60 °C) 1 L GL ,2.5 L GL ,4 L GL ,10 L ST,30 L ST 101772
2-Propanol 1 L GL ,2.5 L GL 100998
Toluene 1 L GL ,2.5 L GL ,4 L GL 108389
Water 1 L GL ,2.5 L GL 102699

GL = glass bottle I ST = stainless steel barrel I * = sum of hexane isomers + methyl cyclopentane (GC) ≥ 99.8 %
GC-ECD (retention range 1,2,4-Trichlorobenzene to Decachlorobiphenyle individual signals (Lindane standard)) :, 3 pg/mL
GC-FID (retention range n-Undecane to n-Tetracontane individual signals (n-Tetradecane standard)) :, 3 ng/mL

SupraSolv® solvents for gas chromatography MS

Solvent Available Pack Sizes Product Number
Acetone 1L GL, 2.5L GL 100658
Acetonitrile 1L GL, 2.5L GL 100665
Cyclohexane 1L GL, 2.5L GL 100667
Dichloromethane, stabilized 1L GL, 2.5L GL 100668
Ethyl acetate 1L GL, 2.5L GL 100789
n-Hexane 1L GL, 2.5L GL 100795
Methanol 1L GL, 2.5L GL 100837
Toluene 1L GL, 2.5L GL 100849
Water 1L GL, 2.5L GL 103702
Water, ACS reagent, for ultratrace analysis 1L GL 14211
1-Methyl-2-pyrrolidinone 1L GL 43729
Methyl pivalate 1L GL 52596

GL = glass bottle I * = sum of hexane isomers + methyl cyclopentane (GC) ≥ 99.8 %
GC-MS (retention range n-Undecane to n-Tetracontane; scanning area 30 - 600 amu individual signals (n-Tetradecane standard)) ≤ 3 ng/mL

SupraSolv® headspace for the analysis of residual solvents according to ICH, Ph Eur and USP

Solvent Available Pack Sizes Product Number
1-Methyl-2-pyrrolidone 0.5L GL, 1L GL, 2.5L GL 102497
Benzylalcohol 1L GL, 2.5L GL 102695
N,N-Dimethylacetamide 0.5L GL, 1L GL 100399
N,N-Dimethylformamide 1L GL, 2.5L GL 100202
Dimethyl sulfoxide 1L GL, 2.5L GL 101900
Water 1L GL, 2.5L GL 100577

GL = glass bottle
Every residual solvent of class 1 acc. CH ≤ 1 μg/g
Every residual solvent of class 2 acc. CH ≤ 10 μg/g
Every residual solvent of class 3 acc. CH ≤ 50 μg/g

SupraSolv® hypergrade solvents for organic trace analysis

Solvent Available Pack Sizes Product Number
Dichloromethane 1L GL 106454
n-Hexane 1L GL, 2.5L GL 104369
n-Pentane 1L GL, 2.5L GL 107288
Petroleum benzine (40 - 60°C) 1L GL, 2.5L GL 116740

GL = glass bottle
* Sum of hexane isomers + methylcyclopentane (GC) > 99.9 %
GC-ECD (retention range Dichloromethane to 1,2,4-Trichlorobenzene individual signals (Tetrachloromethane standard)) ≤ 1 ng/mL
GC-ECD (retention range 1,2,4-Trichlorobenzene to Decachlorobiphenyle individual signals (Lindane standard)) ≤ 2 pg/mL
GC-FID (retention range n-Undecane to n-Tetracontane individual signals (n-Tetradecane standard)) ≤ 2 ng/mL
GC-MS (retention range n-Undecane to n-Tetracontane; scanning area 30 - 600 amu individual signals (n-Tetradecane standard) ≤ 2 ng/mL