Epidermal Growth Factors (EGF) and NRG Family

By: Jennifer Fries, BioFiles 2009, 4.5, 5.

The epidermal growth factor (EGF) family of growth factors is comprised of the normal mammalian gene products of EGF, amphiregulin, betacellulin, heparin-binding EGF (HB-EGF), and transforming growth factor-α (TGF-α), plus pox virus EGF-like protein (PVGF), lin-3 from Caenorhabditis elegans, and spitz from Drosophila. The neuregulin (NRG) or neu differentiation factor (NDF) family of growth factors includes the heregulins (HRG-α and HRG-β), acetylcholine receptor inducing activity (ARIA) and glial growth factor (GGF). The EGF and NRG families are similar in that all members contain one or more EGF-like motifs in the extracellular domain that interacts with a cell surface receptor. Many members of both families also undergo proteolytic cleavages in the region between the EGF-like motif and transmembrane domain and also further toward the N-terminus to release molecules that bind and activate one or more members of the EGF receptor (EGFR) family. Among the members of both families there is a great deal of variations in other extracellular and intracellular structures of the precursor forms. EGF family members all bind and activate EGFR. Members of the NRG family bind to one or more of the EGFR-related receptors designated as erbB-2, erbB-3 or erbB-4. Emphasizing the homologies among the two families, some authors designate the EGFR as HER1 (human EGF receptor-1) and erbB-2-4 as HER2-4.

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Epidermal Growth Factor (EGF)

Product Description Source Recombinant Host Physical Form Assay Cell Type Affected Cat. No.
Epidermal Growth Factor from murine submaxillary gland - lyophilized powder The biological activity is measured in a proliferation assay using BALB/MK cells. ovary cell chrondrocyte endothelial cell granuloma cell mammary epithelial cell vascular endothelial cell fibroblast prostate cell glial cell HeLa cell myeloma cell E4127-.1MG
Epidermal Growth Factor human Escherichia coli lyophilized powder ≥97% SDS-PAGE endothelial cell HeLa cell ovary cell vascular endothelial cell prostate cell myeloma cell fibroblast mammary epithelial cell glial cell granuloma cell chrondrocyte E9644-.2MG
LONG® EGF human Escherichia coli powder - granuloma cell mammary epithelial cell ovary cell prostate cell HeLa cell endothelial cell vascular endothelial cell chrondrocyte fibroblast glial cell myeloma cell E4269-.1MG

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  1. Jones, J.T., et al., Binding specificities and affinities of egf domains for ErbB receptors. FEBS let., 447, 227-231 (1999).
  2. Soler, C., and Carpenter, G., The epidermal growth factor (EGF) family, in The Cytokine Handbook, 3rd Edition, Thomson, A.W., ed., Academic Press (San Diego, CA: 1998), pp.194-197.
  3. Walker, F., and Burgess, A.W., Epidermal growth factor receptor, in The Cytokine Handbook, 3rd Edition, Thomson, A.W., ed., Academic Press (San Diego, CA: 1998), pp.198-201.
  4. Yarden, Y., and Wen, D., Neu differentiation factor (NDF) and the neuregulin (NRG) family, in The Cytokine Handbook, 3rd Edition, Thomson, A.W., ed., Academic Press (San Diego, CA: 1998), pp.146-149.
  5. Earp, H.S., et al., Heterodimerization and functional interaction between EGF receptor family members: a new signaling paradigm with implications for breast cancer researc. Breast Canc. Res. Treat., 35, 115-132 (1995).

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