Applications Using Peptide Libraries

Several applications in the area of drug design and drug delivery utilize peptide libraries. Select a link on our interactive display for descriptions and publications for the highlighted peptide library applications.

Application Description Reference
Antibody development Antibodies to a superantigenic glycoprotein 120 epitope as the basis for developing an HIV vaccine Planque et. al. Journal of Immunology, 2012, 189: 5367-81
Peptide mimetics Peptide agonist of the thrombopoietin receptor as potent as the natural cytokine Cwirla Science, 1997, 276: 1696-99
Protein structure activity studies PEPscreen peptide libraries have been used to study structural properties of proteins such as Human Thrombin. Kasetty et. al. Antimicrob. Agents Chemother. 2011, 55:2880-90
Plant biology S cysteine‐rich (SCR) binding domain analysis of the Brassica self‐incompatibility S‐locus receptor kinase Kemp  New Phytologist, 2007, 175:619-29
Protein conformation studies Local descriptors of protein structure: A systematic analysis of the sequence-structure relationship in proteins using short- and long-range interactions Hvidsten et al. Proteins: Structure, Function, and Bioinformatics, 2009,75 (4), 870–884
T-cell/B-cell assays A systematic approach for comprehensive T-cell epitope discovery using peptide libraries Beissbarth et al. Bioinformatics. 2005, 21, 29-37.
Protease studies Proteome-derived, database-searchable peptide libraries for identifying protease cleavage sites Schilling et al. Nat Biotechnol. 2008, 26(6):685-94
Protein kinase studies Substrate screening of protein kinases: detection methods and combinatorial peptide libraries Kim  et al. Biopolymers. 2010;94(6):753-62
Vaccine development Evaluation of nonspreading Rift Valley fever virus as a vaccine vector using influenza virus hemagglutinin as a model antigen Oreshkova et al. Vaccine. 2014; 32(141): 5323-9.
Protein-protein interactions Detecting protein–protein interactions based on kinase-mediated growth induction of mammalian cells Mabe et al. Scientific Reports 2014, 4, 6127
Receptor-ligand assays Small Peptides as Potent Mimetics of the Protein Hormone Erythropoietin Wrighton et al. Science, 1996, 273, 458-463
Peptide drug carriers Novel peptide–dendrimer conjugates as drug carriers for targeting nonsmall cell lung cancer Liu et al. Int J Nanomedicine. 2011; 6: 59–69
Drug/proDrug design The Synthesis of a Prodrug of Doxorubicin Designed to Provide Reduced Systemic Toxicity and Greater Target Efficacy Garsky et al. J. Med. Chem. 2001, 44, 4216-4224
Food industry Applying Combinatorial Chemistry and Biology to Food Research Wong et al. J. Agric. Food Chem. 2004, 52, 7187−7198