Cell Therapy Manufacturing Expansion Vessels

Microcarrier-based bioreactor expansion of adherent cells improves economics and efficiency in cell therapy manufacturing. Additionally, the scalability of stirred tank bioreactors, coupled with the simplicity of sampling and closed system design for downstream processing, demonstrate ideal processes for manufacturing.

  • Robust and predictable manufacturing solutions
  • Cost-effective
  • Increased flexibility and utilization of facilities
  • Ease-of-use through automated solutions
  • Traceability through in-line monitoring, on-demand control and data logging

Featured Resources

Article

Interested in upstream process development for cell-based therapeutic applications? Our paper outlines parameters to be evaluated for successful transfer, including agitation rate, pH and dissolved oxygen (DO) control set-points and media formulation.

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Webinar

Investing in Process Development for Increased MSC Production in Stirred Tank Bioreactors

Speaker: Kara Levine, Ph.D., Head of Systems and Tools, Cell Therapy Bioprocessing

In this webinar, you will learn:

  • Process development approaches for production scale-up of mesenchymal stem cells (MSCs)
  • Implementing single-use, closed systems for manufacturing cell therapies
  • Case studies focusing on strategies to optimize DO control and agitation rates for microcarrier-based cultures

Featured product highlight

Single-use, stirred-tank bioreactors offer industrial manufacturing solutions. MSCs expanded in our 50L stirred tank bioreactor retain functional attributes compared to planar seed train as observed with (A) activation marker expression and (B) multipotency.