Chemical Compatibility of Filter Components:
Compatibility of materials used in the construction of Millipore products

The tables on the following pages contain recommendations based solely upon ratings found in several published solubility and compatibility tables. A listing of sources appears below. The tables do not contain results from any actual usage experiments conducted at Millipore.

Ratings for this table were made on the following basis:

R = Recommended. Chosen for only those polymer-solvent combinations that showed top ratings in the published compatibility tables.

GR = Generally Recommended. Where no polymer-solvent specific information was available, general compatibility with a solvent type was stated; for example, PES is compatible with alcohols.

LTD = Limited. Chosen for those polymer-solvent combinations that showed both top and less-than-top ratings in published compatibility tables where exposure times of less than 24 hours at room temperature are recommended. Component materials may stress crack or swell affecting filtration efficiency.

NR = Not Recommended. Chosen for those polymer-solvent combinations that showed less-than-top ratings in the published compatibility tables.

Caution

Please note the following:

  1. These recommendations assume pure solutions at room temperature and pressure without applied stresses. Time of exposure is not considered. These are critical assumptions as polymer properties are strongly affected by environmental conditions, time, the presence of external stress and the presence of additives. It is not safe to assume that property changes are linearly related to changing temperature. A 10 °C increase in temperature, for example, may place the test conditions closer to the glass transition of the polymer, thus allowing greater penetration of solvent molecules. This has a plasticizing effect, further lowering the glass transition and resulting in a modulus drop of up to three orders of magnitude. The glass transition of nylons, for example, has been shown to range from below -50 °C to +70 °C depending upon their moisture content.

  2. These recommendations assume that each polymer category has a uniform chemistry, molecular weight distribution and thermomechanical history. This assumption will never be true, and, in some cases, variation has a distinct influence on compatibility. For example, solvent compatibility of cellulose esters is strongly dependent upon their degree of substitution (acetylation/nitration). Crystalline morphology and degree of crystallinity influences compatibility of semi-crystalline polymers and can vary significantly. Polyethyleneterephthalate, for example, can be quenched to obtained samples with almost no crystallinity or annealed to obtain samples with >50% crystallinity. The response time of these two polyesters, although chemically identical, will be quite different. The effect of molecular weight distribution and degree of branching on solvent compatibility can be seen by comparing the solvent compatibility of LDPE, LLDPE, HDPE and UPE. Such specific information concerning polymers evaluated does not accompany published compatibility tables.

  3. The definition of solvent compatibility for Millipore products differs from that used in determining the ratings given in published compatibility tables. Such tables are generally concerned with chemical attack and significant losses in strength and/or dimensional changes. A top designation, for example, might be designated for solvent-polymer combinations with <10% swelling, which is high. Other compatibility tables may make recommendations based upon dimensional change as a function of time. This is difficult to relate to a membrane that may respond almost immediately to immersion in solvent. In addition, solvent-membrane compatibility requires additional consideration of filtration-specific factors. None of these published compatibility guides, for example, monitors the solvent’s ability to wet a membrane or increase extractables.

  4. This table does not consider solvent safety issues.

Chemical Compatibility of Millipore Products

This table shows the chemical compatibility of materials used in the fabrication of Millipore devices and membranes.

Please refer to the specification tables on product-specific pages for materials found in specific Millipore devices.

The following descriptions are abbreviated. Please see the beginning of this section for complete information.

R = Recommended; GR = Generally Recommended LTD = Limited Recommendation; NR = Not Recommended; GNR = Generally Not Recommended; TST = Testing Recommended; ND = No Data Presently Available

Chemical Compatibility of  Millipore Products

This table shows the chemical compatibility of materials used in the fabrication of  Millipore devices and membranes.

Please refer to the specification tables on product-specific pages for materials found in specific Millipore devices.

The following descriptions are abbreviated. Please see the beginning of this section for complete information.

R = Recommended; GR = Generally Recommended LTD = Limited Recommendation; NR = Not Recommended; GNR = Generally Not Recommended; TST = Testing Recommended; ND = No Data Presently Available

Chemical Compatibility of Millipore Products

This table shows the chemical compatibility of materials used in the fabrication of  Millipore devices and membranes.

Please refer to the specification tables on product-specific pages for materials found in specific Millipore devices.

The following descriptions are abbreviated. Please see the beginning of this section for complete information.

R = Recommended; GR = Generally Recommended LTD = Limited Recommendation; NR = Not Recommended; GNR = Generally Not Recommended; TST = Testing Recommended; ND = No Data Presently Available

Chemical Compatibility of Millipore Products
This table shows the chemical compatibility of materials used in the fabrication of Millipore devices and membranes.


Please refer to the specification tables on product-specific pages for materials found in specific Millipore device

The following descriptions are abbreviated. Please see the beginning of this section for complete information.

R = Recommended; GR = Generally Recommended LTD = Limited Recommendation; NR = Not Recommended; GNR = Generally Not Recommended; TST = Testing Recommended; ND = No Data Presently Available

Chemical Compatibility of Millipore Products

This table shows the chemical compatibility of materials used in the fabrication of Millipore devices and membranes.

Please refer to the specification tables on product-specific pages for materials found in specific Millipore devices.

The following descriptions are abbreviated. Please see the beginning of this section for complete information.

R = Recommended; GR = Generally Recommended LTD = Limited Recommendation; NR = Not Recommended; GNR = Generally Not Recommended; TST = Testing Recommended; ND = No Data Presently Available

Chemical Compatibility of Millipore Products

This table shows the chemical compatibility of materials used in the fabrication of Millipore devices and membranes.

Please refer to the specification tables on product-specific pages for materials found in specific Millipore devices.

The following descriptions are abbreviated. Please see the beginning of this section for complete information.

R = Recommended; GR = Generally Recommended LTD = Limited Recommendation; NR = Not Recommended; GNR = Generally Not Recommended; TST = Testing Recommended; ND = No Data Presently Available

Chemical Compatibility of Millipore Products

This table shows the chemical compatibility of materials used in the fabrication of Millipore devices and membranes.

Please refer to the specification tables on product-specific pages for materials found in specific Millipore devices.

The following descriptions are abbreviated. Please see the beginning of this section for complete information.

R = Recommended; GR = Generally Recommended LTD = Limited Recommendation; NR = Not Recommended; GNR = Generally Not Recommended; TST = Testing Recommended; ND = No Data Presently Available

Chemical Compatibility of Millipore Products

This table shows the chemical compatibility of materials used in the fabrication of Millipore devices and membranes.

Please refer to the specification tables on product-specific pages for materials found in specific Millipore devices.

The following descriptions are abbreviated. Please see the beginning of this section for complete information.

R = Recommended; GR = Generally Recommended LTD = Limited Recommendation; NR = Not Recommended; GNR = Generally Not Recommended; TST = Testing Recommended; ND = No Data Presently Available

Chemical Compatibility of Millipore Ultrafiltration Products and Centrifugal Filters

This table reflects the chemical compatibility of materials used in the fabrication of Millipore devices.

Please refer to the specification tables on product-specific pages for materials found in specific Millipore devices.

 

Chemical Compatibility of Millipore Ultrafiltration Products and Centrifugal Filters

This table reflects the chemical compatibility of materials used in the fabrication of Millipore devices.

Please refer to the specification tables on product-specific pages for materials found in specific Millipore devices.

The following descriptions are abbreviated. Please see the beginning of this section for complete information.

R = Recommended; GR = Generally Recommended LTD = Limited Recommendation; NR = Not Recommended;

GNR = Generally Not Recommended; TST = Testing Recommended; ND = No Data Presently Available

Chemical Compatibility of Millipore Ultrafiltration Products and Centrifugal Filters

This table reflects the chemical compatibility of materials used in the fabrication of Millipore devices.

Please refer to the specification tables on product-specific pages for materials found in specific Millipore devices.

 

Chemical Compatibility Guide for MultiScreen® Filter Plates

Ratings are based on 100% or concentrated solutions, unless otherwise indicated. Aromatic hydrocarbons (especially ketones, DMF, DMAC, DMSO, THF, acetonitrile) and chlorinated hydrocarbons will attack both membranes and plastics. A chemical listed as NR may be suitable in low concentrations for short exposures, but this must be determined on an individual assay basis.

Compatibility of MultiScreen®HTS and MultiScreen® Classic Filter Plates with Various Reagents

R = Recommended, no known restrictions, NR = Not recommended, membrane or plate severely attacked by chemical, L = Limited, chemical resistance marginal, short time exposures should be tested individually for application. Dilution with water or other non-solvent will likely enhance compatibility.

  1. Scintillants should only be used with Barex® or SAN plates.
  2. Surfactants are in general readily usable with all MultiScreen® plate types. However, before quantitative fluid transfer to a receiver plate, it is essential that the plate be rinsed with non- surfactant containing fluid (e.g., 100 μL PBS) and then the underdrain be thoroughly blotted prior to adding the material which will ultimately be collected. Triton®-X 100 should not be used with MCE membrane in concentrations greater than 5% (the membrane will appear to lose flow).

Compatibility of MultiScreen®HTS and MultiScreen® Classic Filter Plates with Various Reagents

R = Recommended, no known restrictions, NR = Not recommended, membrane or plate severely attacked by chemical, L = Limited, chemical resistance marginal, short time exposures should be tested individually for application. Dilution with water or other non-solvent will likely enhance compatibility.

  1. Scintillants should only be used with Barex® or SAN plates.
  2. Surfactants are in general readily usable with all MultiScreen® plate types. However, before quantitative fluid transfer to a receiver plate, it is essential that the plate be rinsed with non- surfactant containing fluid (e.g., 100 μL PBS) and then the underdrain be thoroughly blotted prior to adding the material which will ultimately be collected. Triton®-X 100 should not be used with MCE membrane in concentrations greater than 5% (the membrane will appear to lose flow).

Chemical Compatibility Guide for the MultiScreen® Vacuum Manifold

The following table outlines the solvents that have been evaluated for compatibility with the various components of the MultiScreen®HTS vacuum manifold. In general, the manifold will tolerate the same chemicals as the rest of the system.

However, when using concentrated acids, it is important to rinse through the entire manifold at the end of procedures, especially if collection is done through the manifold into a trap, rather than using the collection trays.

E = Excellent performance, G = Good performance, R = Rinse after contact, NR = Not recommended

References used in developing this table:

  1. Polymer Handbook, ed III., Section VII p. 379-402 lists solvents and nonsolvents for a variety of polymers
  2. Organic Polymer Chemistry, 2nd edition, K.J.Saunders, Chapman & Hall, 1988.
  3. Appropriate sections in Encyclopedia of Polymer Science and Engineering
  4. Chemical Resistance Guide for Elastomers, Compass Publications. Kenneth M.Pruett, 1988.
  5. Compass Corrosion Guide II, Compass Publications. Kenneth M.Pruett, 1983.
  6. http://www.pspglobal.com/nfvitongrades.html (Compatibility of vinylidiene fluoride-hexafluoropropylene copolymer)
  7. http://www.pspglobal.com/nfmaterials.html (Compatibility of O-ring materials)
  8. http://www.ab.ust.hk/sepo/tips/ch/ch004.htm (General polymer compatibility)
  9. http://www.customadvanced.com/chemical-resistance-chart.html
  10. Chapiro, Mankowski & Schmitt, J.Polymer Science: Chemistry edition, Vol.20, 1982, p. 1791-1796
  11. Bottino, Capannelli, Munari & Turturro, J.Polymer Science: Polymer Physics, Vol 26, 1988, p. 785-94.
  12. CRC Handbook of Polymer-Liquid Interaction Parameters and Solubility Parameters, Allan F.M. Barton, CRC Press, 1990.

Materials

     

References

  1. Polymer Handbook, ed III., Section VII p. 379-402 lists solvents and nonsolvents for a variety of polymers
  2. Organic Polymer Chemistry, 2nd edition, K.J.Saunders, Chapman & Hall, 1988.
  3. Appropriate sections in Encyclopedia of Polymer Science and Engineering
  4. Chemical Resistance Guide for Elastomers, Compass Publications. Kenneth M.Pruett, 1988.
  5. Compass Corrosion Guide II, Compass Publications. Kenneth M.Pruett, 1983.
  6. http://www.pspglobal.com/nfvitongrades.html (Compatibility of vinylidiene fluoride-hexafluoropropylene copolymer)
  7. http://www.pspglobal.com/nfmaterials.html (Compatibility of O-ring materials)
  8. http://www.ab.ust.hk/sepo/tips/ch/ch004.htm (General polymer compatibility)
  9. http://www.customadvanced.com/chemical-resistance-chart.html
  10. Chapiro, Mankowski & Schmitt, J.Polymer Science: Chemistry edition, Vol.20, 1982, p. 1791-1796
  11. Bottino, Capannelli, Munari & Turturro, J.Polymer Science: Polymer Physics, Vol 26, 1988, p. 785-94.
  12. CRC Handbook of Polymer-Liquid Interaction Parameters and Solubility Parameters, Allan F.M. Barton, CRC Press, 1990.

 

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