[Skip to Content](https://www.sigmaaldrich.com#main-content) [![MilliporeSigma](https://www.sigmaaldrich.com/static/logos/purple/millipore_sigma.svg)](https://www.sigmaaldrich.com/US/en) Products Cart0 USEN Products ProductsApplicationsServicesResourcesSupport [Analytical Chemistry](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry)[Cell Culture & Analysis](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis)[Chemistry & Biochemicals](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals)[Clinical & Diagnostics](https://www.sigmaaldrich.com/US/en/products/clinical-diagnostics)[Filtration](https://www.sigmaaldrich.com/US/en/products/filtration) [Greener Alternative Products](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/greener-alternative-products) [Industrial Microbiology](https://www.sigmaaldrich.com/US/en/products/industrial-microbiology)[Lab Automation](https://www.sigmaaldrich.com/US/en/products/lab-automation)[Labware](https://www.sigmaaldrich.com/US/en/products/labware)[Materials Science](https://www.sigmaaldrich.com/US/en/products/materials-science)[Molecular Biology & Functional Genomics](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics)[mAbs Development & Manufacturing](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies)[mRNA Development & Manufacturing](https://www.sigmaaldrich.com/US/en/integrated-offerings/mrna-development-manufacturing)[Pharma & Biopharma Manufacturing](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing)[Protein Biology](https://www.sigmaaldrich.com/US/en/products/protein-biology)[Water Purification](https://www.sigmaaldrich.com/US/en/products/water-purification) [Analytical Chemistry](https://www.sigmaaldrich.com/US/en/applications/analytical-chemistry)[Cell Culture & Analysis](https://www.sigmaaldrich.com/US/en/applications/cell-culture-and-cell-culture-analysis)[Chemistry & Synthesis](https://www.sigmaaldrich.com/US/en/applications/chemistry-and-synthesis) [Clinical & Diagnostics](https://www.sigmaaldrich.com/US/en/applications/clinical-testing-and-diagnostics-manufacturing)[Environmental & Cannabis Testing](https://www.sigmaaldrich.com/US/en/applications/environmental-testing-and-industrial-hygiene)[Food & Beverage Testing & Manufacturing](https://www.sigmaaldrich.com/US/en/applications/food-and-beverage-testing-and-manufacturing)[Genomics](https://www.sigmaaldrich.com/US/en/applications/genomics)[Materials Science & Engineering](https://www.sigmaaldrich.com/US/en/applications/materials-science-and-engineering)[Microbiological Testing](https://www.sigmaaldrich.com/US/en/applications/microbiological-testing)[mAbs Development & Manufacturing](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies)[mRNA Development & Manufacturing](https://www.sigmaaldrich.com/US/en/integrated-offerings/mrna-development-manufacturing)[Pharma & Biopharma Manufacturing](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing)[Protein Biology](https://www.sigmaaldrich.com/US/en/applications/protein-biology)[Research & Disease Areas](https://www.sigmaaldrich.com/US/en/applications/research-disease-areas)[Water Purification](https://www.sigmaaldrich.com/US/en/applications/water-purification) [Contract Manufacturing](https://www.sigmaaldrich.com/US/en/services/contract-manufacturing)[Contract Testing](https://www.sigmaaldrich.com/US/en/services/contract-testing)[Custom Products](https://www.sigmaaldrich.com/US/en/services/custom-products)[Digital Solutions for Life Science](https://www.sigmaaldrich.com/US/en/services/software-and-digital-platforms)[IVD Development & Manufacturing](https://www.sigmaaldrich.com/US/en/services/ivd-development-manufacturing)[Product Services](https://www.sigmaaldrich.com/US/en/services/product-services)[Support](https://www.sigmaaldrich.com/US/en/services/support) [Documents](https://www.sigmaaldrich.com/US/en/documents-search?tab=coa) [Learning CenterNew](https://www.sigmaaldrich.com/US/en/life-science/learning-center) [Customer Support](https://www.sigmaaldrich.com/US/en/support/customer-support) [Contact Us](https://www.sigmaaldrich.com/US/en/collections/offices) [Get Site Smart](https://www.sigmaaldrich.com/US/en/life-science/ecommerce/website-update-info) [FAQ](https://maestro.my.site.com/knowledgeportal/s/) [Quality & Regulatory](https://www.sigmaaldrich.com/US/en/life-science/quality-and-regulatory-management) [Calculators & Apps](https://www.sigmaaldrich.com/US/en/support/calculators-and-apps) [Webinars](https://www.sigmaaldrich.com/US/en/collections/webinars) [Login / Register](https://www.sigmaaldrich.com/oidc-sign-in) [Order Lookup](https://www.sigmaaldrich.com/US/en/order-lookup) [Quick Order](https://www.sigmaaldrich.com/US/en/quick-order) Cart0 [Home](https://www.sigmaaldrich.com/US/en)[qPCR](https://www.sigmaaldrich.com/US/en/applications/genomics/qpcr)Quantitative PCR Basics # Quantitative PCR Basics *A Technical Guide to PCR Technologies* __On This Page__ - [Basic Principles](https://www.sigmaaldrich.com#basic) - [Quantification and Analysis of gDNA Targets](https://www.sigmaaldrich.com#targets) - [Quantification and Analysis of mRNA Transcripts](https://www.sigmaaldrich.com#mrna) - [Quantification and Analysis of ncRNA Transcripts](https://www.sigmaaldrich.com#transcripts) - [qPCR Requirements](https://www.sigmaaldrich.com#qpcr) - [The MIQE Guidelines](https://www.sigmaaldrich.com#miqe) - [Are You MIQE Compliant?](https://www.sigmaaldrich.com#are) Quantitative PCR (formally quantitative real-time PCR, qPCR) detection builds on the basic PCR technique and allows researchers to estimate the quantity of starting material in a sample. Since the products are detected as the reaction proceeds, qPCR has a much wider dynamic range of analysis than conventional, end-point PCR; from a single copy to around 1011 copies are detectable within a single run. Quantitative real-time PCR and subsequent amplicon detection is carried out in a closed-tube format which eliminates the need for post-PCR manipulation, such as gel electrophoresis and significantly reduces the risk of cross contamination. The basic principles of qPCR are discussed on this page, and the mechanisms of the common detection chemistries are described in [Quantitative PCR and Digital PCR Detection Methods](https://www.sigmaaldrich.com/US/en/technical-documents/technical-article/genomics/qpcr/quantitative-pcr-and-digital-pcr-detection-methods). ## [](https://www.sigmaaldrich.com)Basic Principles When performing qPCR, a fluorescent reporter dye is used as an indirect measure of the amount of nucleic acid present during each amplification cycle. The increase in fluorescent signal is directly proportional to the quantity of exponentially accumulating PCR product molecules (amplicons) produced during the repeating phases of the reaction (see [Polymerase Chain Reaction](https://www.sigmaaldrich.com/US/en/technical-documents/technical-article/genomics/pcr/polymerase-chain-reaction)). Reporter molecules are categorized as; double-stranded DNA (dsDNA) binding dyes, dyes conjugated to primers, or additional dye-conjugated oligonucleotides, referred to as probes ([Quantitative PCR and Digital PCR Detection Methods](https://www.sigmaaldrich.com/US/en/technical-documents/technical-article/genomics/qpcr/quantitative-pcr-and-digital-pcr-detection-methods)). The use of a dsDNA-binding dye, such as SYBR® Green I, represents the simplest form of detection chemistry. When free in solution or with only single-stranded DNA (ssDNA) present, SYBR Green I dye emits light at low signal intensity. As the PCR progresses and the quantity of dsDNA increases, more dye binds to the amplicons and hence, the signal intensity increases. Alternatively, a probe (or combination of two depending on the detection chemistry) can add a level of detection specificity beyond the dsDNA-binding dye, since it binds to a specific region of the template that is located between the primers. The most commonly used probe format is the Dual-Labeled Probe (DLP; also referred to as a Hydrolysis or TaqMan® Probe). The DLP is an oligonucleotide with a 5’ fluorescent label, e.g., 6-FAM™ and a 3’ quenching molecule, such as one of the dark quenchers e.g., BHQ®1 or OQ™ ([Quantitative PCR and Digital PCR Detection Methods](https://www.sigmaaldrich.com/US/en/technical-documents/technical-article/genomics/qpcr/quantitative-pcr-and-digital-pcr-detection-methods)). These probes are designed to hybridize to the template between the two primers and are used in conjunction with a DNA polymerase that has inherent 5’ to 3’ exonuclease activity. When the DLP is free in solution, the signal intensity is low because the reporter dye is in close proximity to the quencher moiety. As more of the template is produced during the reaction, more probes hybridize to the template, which in turn are cleaved by the 5’ to 3’ exonuclease activity of the advancing DNA polymerase. The fluorescent signal intensity increases as the 5’ reporter dye is released into solution. The use of probes labeled with different reporter dyes allows for the simultaneous detection and quantification of multiple targets in a single (multiplex) reaction. A typical qPCR run consists of repeated cycles of alternating temperature incubations, Cycling Procedure 3.1. This profile is often used when dsDNA-binding dyes, Molecular Beacons, or Scorpion® Probes are the chosen detection chemistries for qPCR. Primer extension is most efficient at 72 °C because this is the optimal temperature for processivity of most DNA polymerases. At 72 °C, polymerization occurs at a rate of approximately 100 bases per second. However, there is still processivity at lower temperatures that is sufficient to amplify shorter templates. qPCR amplicons are typically shorter (<200 bases) than conventional PCR products, thus extension is often combined with annealing in a single step at 60 °C when working with Dual-Labeled Probles (Cycling Procedure 3.2). ### [](https://www.sigmaaldrich.com)Cycling Procedure 3.1 An example of a standard qPCR profile using dsDNA-binding dye, Molecular Beacon, or Scorpions® Probe detection. - __Initial Denaturation:__ The reaction temperature is increased to 95 °C and the sample is incubated for 2–10 min (the time depends on the polymerase enzyme hot start mechanism) to ensure that all all complex targets (dsDNA) are separated and are single stranded and available for amplification - __Cycling:__ 1. __Denaturation:__ The reaction temperature is increased to 95 °C for 10 sec to melt all dsDNA. 2. __Annealing:__ The temperature is lowered to 60 °C for 30 sec to promote primer and probe (if included) binding to the template. 3. __Extension:__ Subsequent elongation occurs at an increased temperature of 72 °C, which is optimal for TaqDNA polymerase processivity. Duration of extension will be dependent upon amplicon size (30 sec per 1 kb). The period of elongation depends upon the desired length of the amplicon and the enzyme used. Since qPCR amplicons are short, this is typically 5–30 sec. - __Repeat:__ Steps 1–3 are repeated, usually for 40 cycles. ### [](https://www.sigmaaldrich.com)Cycling Procedure 3.2 An example two-step cycling qPCR profile for DLP detection. - __Initial Denaturation:__ The temperature is increased to 95 °C and the reaction is incubated for 2–10 min (depending on the hot start properties of the polymerase enzyme) - __Cycling:__ 1. __Denaturation:__ The reaction temperature is increased to 95 °C for 10 sec to melt all dsDNA. 2. __Annealing and Extension:__ The temperature is lowered to 60 °C for 30 sec to promote primer binding to the template and subsequent elongation occurs due to sufficient activity of the DNA polymerase at this temperature. - __Repeat:__ Steps 1–2 are repeated, usually for 40 cycles. The change in fluorescence over the course of the reaction is measured by a real-time PCR thermal cycler. Dedicated real-time PCR instruments combine temperature cycling with an optical unit. The optical unit provides light at a suitable wavelength to excite the fluorophore and detects the resulting emission. Many modern instruments have an affixed display screen or nearby computer monitor, which allows the reaction to be tracked as it progresses (__Figure 3.1__). ![Example qPCR Assay Data](https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/images/technical-documents/articles/genomics/qpcr/quantitative-pcr-cycle-ab/quantitative-pcr-cycle-ab.jpg "Example qPCR Assay Data") __Figure 3.1.__Example qPCR Assay Data. A) The different phases of the reaction. Baseline: The initial concentration of template is low; therefore, the fluorescence intensity is too low to be detected and only the background signal is evident. Exponential: After the target yield has reached the detection threshold, shown as the red threshold line, the course of the reaction can be followed through the exponential phase. Linear: As the concentration of template increases the available DNA polymerase concentration reduces and the reaction rate decreases. Plateau: The reaction is at the maximum yield. B) Individual reactions are characterized by the cycle at which fluorescence first rises above the threshold, which is referred to as the Quantification Cycle (Cq). If the starting material is abundant, amplification is observed in earlier cycles and the Cq is lower. If the starting material is scarce, amplification is observed in later cycles and the Cq is higher. This correlation between fluorescence, Cq and amount of amplified product enables quantification of the template over a wide dynamic range. ## [](https://www.sigmaaldrich.com)Quantification and Analysis of gDNA Targets Quantitative real-time PCR can be readily applied to analysis of gDNA targets. Such studies may be genotyping/SNP determination, methylation analysis, screening transgenic sequences, or monitoring of insertions and deletions. ## [](https://www.sigmaaldrich.com)Quantification and Analysis of mRNA Transcripts A common application of qPCR is gene expression analysis, e.g., comparing the mRNA concentrations of a gene of interest between control and treated samples. The mRNA can be quantified via a two-step or one-step RT-qPCR process (see [Reverse Transcription Quantitative Real-time PCR](https://www.sigmaaldrich.com/US/en/technical-documents/technical-article/genomics/gene-expression-and-silencing/reverse-transcription), for more details of RT reactions). ### Two-step RT-qPCR The reverse transcription and qPCR reactions are carried out sequentially in separate tubes. Either total RNA or, less commonly poly(A)+ RNA, is used as the starting material and cDNA is produced by elongation from oligo-dT primers, random primers, a blend of oligo-dT primers/random primers, or gene-specific primers using a reverse transcriptase enzyme. An aliquot of this reaction is then added to the qPCR. ### One-step RT-qPCR When the reverse transcription and qPCR reactions are combined into one tube, the experimental setup is simplified and there is a lower chance of contamination because there is no requirement for further handling of the sample. ## [](https://www.sigmaaldrich.com)Quantification and Analysis of ncRNA Transcripts Most non-coding RNAs are longer than 100 nucleotides and therefore, can be detected and quantified by RT-qPCR with the same techniques that are used for mRNA analysis. In contrast, short non-coding RNAs, such as micro and piwi RNAs, are essentially the length of a single PCR primer. As a consequence, a technique that lengthens these short RNAs is needed before performing qPCR. Two main approaches are adopted in commercially available systems: 1) use of a stemloop RT primer and 2) poly-A tailing followed by RT with an oligo-dT adapter primer (__Figure 3.2__). An alternative approach developed by Casoldi et al., that is not commercially available, uses ligation of an adapter molecule to all RNA in the sample and specific primer design to differentiate between the desired targets1,2. The stem-loop RT primer approach was developed and commercialized by Applied Biosystems (currently Life Technologies/Thermo) for subsequent TaqMan probe-based qPCR3. As illustrated in __Figure 3.2A__, the 5’-end of the RT primer can base-pair with a region several nucleotides from its own 3’-end to create a base-paired stem separated by an unpaired loop. All except the last few nucleotides at the 3’-end of the RT primer are universal, that is, they contain the same sequence in all miRNA primers. The last few nucleotides that extend 3’ from the stem are complementary to the 3’-end of a target miRNA. Extension of the primer along a miRNA template creates a cDNA that can be amplified with a miRNA-specific forward primer and a universal reverse primer, the latter of which is complementary to the 5’-end of the stem-loop RT primer. All other commercial miRNA qPCR methods, including our MystiCq® brand, use poly-A tailing to lengthen the miRNA, as described by Shi and Chiang4. Poly(A) Polymerase (PAP), a template-independent enzyme, catalyzes the transfer of adenosine residues from ATP to the 3’-end of any RNA. As illustrated in __Figure 3.2B__, RT can then be performed using an oligo-dT primer. The oligo-dT primer includes an adapter sequence at its 5’-end, which enables subsequent qPCR with a forward primer that is complementary to a specific miRNA and a reverse primer that is complementary to the adapter sequence. ![RT and qPCR of miRNA](https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/images/technical-documents/articles/genomics/qpcr/mirna-rt-q-pcr-ab/mirna-rt-q-pcr-ab.jpg "RT and qPCR of miRNA") __Figure 3.2.__There are two commercially available methods for RT and qPCR of miRNA. A) A looped primer is used to prime the RT step after hybridization to the 3’ end of the miRNA. PCR extension through the loop results in a combined miRNA and universal sequence which is long enough for amplification B) Addition of a poly A tail to the miRNA provides a priming site for a primer that is composed of a oligo-dT tract and a universal priming sequence. Nucleic acids research by Oxford University Press. Reproduced with permission of Oxford University Press in the format reuse in a book/e-book via Copyright Clearance Center. Both commercial approaches have advantages and disadvantages. Stem-loop priming allows 2-step RT-qPCR, whereas most poly-A tailing methods require an additional step for RT before qPCR. There are products that combine poly-A tailing and RT in a single reaction for 2-step PAP tailing/RT-qPCR. However, detection may be less sensitive with this approach (unpublished internal results). Conversely, poly-A tailing followed by RT produces a stable pool of cDNA that can be used to detect any microRNA, mRNA, or other RNA, immediately or at any time in the future. With the stem-loop/TaqMan approach, a different primer is needed for detection of each miRNA. Multiple stem-loop primers can be added to the same RT reaction5 and pools of RT primers for multiple miRNAs may be purchased from Life Technologies to perform multiplex RT. However, neither option allows for qPCR detection of miRNAs discovered at a later date, nor do they allow qPCR to detect mRNA from the same cDNA. The system described by Castoldi et al1,2 is unique in that it does provide the means to detect mRNA, precursor and fully processed miRNA molecules from the same total RNA sample. ## [](https://www.sigmaaldrich.com)qPCR Requirements ### Instruments Many qPCR instruments have been designed to support a specific range of applications, e.g., contrast the capability of the ABi 7900 high throughput instrument using automatic loading of 384-well plates with the Illumina produced and marketed Eco instrument that supports a single 48-well plate. Therefore, the most suitable instrument meets the needs of the research. It is desirable to select an instrument with user friendly software that performs the most desirable functions and has flexibility in terms of data output so that it can be easily manipulated in downstream statistical analysis software packages. This reduces the time required to train personnel and therefore to begin generating results. Additional features that are required include a PCR block that is absolutely uniform (an absolute maximum deviation of 1 Cq = 2-fold across 96 wells of replication) and an optical system that excites and detects emission as sensitively and as evenly as possible across a wide range of wavelengths. This allows for a wide choice of fluorophores and enables multiplexing. Other features to consider are the operating costs associated with specific consumables, e.g., if a standard microtitre plate is not used for reactions and also the convenience of loading plates/tubes that are non-standard format. ### Template Very few copies of target nucleic acid (equivalent to about 100 pg of gDNA or cDNA) are required to initiate qPCR. To minimize contamination with reaction inhibitors, the starting template amount should be kept to the minimum required to achieve accurate quantification. When the starting material is RNA, primer design and DNase I treatment will reduce signals that may be generated from gDNA contamination. ### Primers Whether using a dsDNA-binding dye or a probe-based detection chemistry, designing high-quality primers is one of the most critical pre-experimental steps in qPCR. For a detailed discussion of assay design, [PCR, qPCR, dPCR Assay Design](https://www.sigmaaldrich.com/US/en/technical-documents/protocol/genomics/pcr/pcr-qpcr-dpcr-assay-design). To maximize sensitivity and specificity, any required modifications, such as Locked Nucleic Acid, should be included ([qPCR Detection Chemistry](https://www.sigmaaldrich.com/US/en/technical-documents/technical-article/genomics/qpcr/quantitative-pcr-and-digital-pcr-detection-methods)). ### Probe(s) When using probes as the amplicon detection mechanism, primer dimers and nonspecific products are not detected but should be avoided because they can lower reaction efficiency. To maximize sensitivity and specificity, the appropriate probe type for the application should be selected and any required modifications, such as Locked Nucleic Acid, included ([qPCR Detection Chemistry](https://www.sigmaaldrich.com/US/en/technical-documents/technical-article/genomics/qpcr/quantitative-pcr-and-digital-pcr-detection-methods)). ### dNTPs [Standard PCR and qPCR master mixes](https://www.sigmaaldrich.com/US/en/technical-documents/technical-article/genomics/pcr/pcr-master-mix) contain dATP, dCTP, dGTP and dTTP. However, some mixes are available that replace dTTP with dUTP. Products from previous reactions run with dUTP will contain uracil instead of thymine. These are then susceptible to cleavage by Uracil-DNA-Glycosylase (UNG). Therefore, prior incubation of subsequent reactions with UNG prevents carryover contamination between reactions. To be effective, all PCRs in the laboratory must use dUTP. ### Magnesium Magnesium chloride (MgCl2) is necessary for reverse transcriptase, Taq DNA polymerase and Taq DNA 5’ to 3’ exonuclease activity. Optimum Mg2+ concentrations for reactions containing DLPs are usually between 3–6 mM. The majority of master mixes contain MgCl2, however, it is sometimes necessary to optimize the concentration, so an additional tube of pure MgCl2 is typically included with the master mix product (see [Assay Optimization and Validation](https://www.sigmaaldrich.com/US/en/technical-documents/technical-article/genomics/pcr/assay-optimization-and-validation)). In some cases, a reaction mix that does not contain MgCl2 may be required so that a low concentration can be used, e.g., when using Scorpions® Probe detection. ### Reverse Transcriptase A reverse transcriptase enzyme that provides high yields of cDNA, while retaining activity at high temperature, is critical to the success of RT-qPCR. Performance at high temperatures helps to ensure that regions of RNA with significant secondary structure are destabilized and accessible for hybridization and subsequent amplification. When performing one-step RTqPCR, high-temperature performance allows the use of genespecific primers with high melting temperatures (Tm), which increases reaction specificity. When performing two step protocols, it is important to ensure that the enzyme results in a linear and proportional yield of cDNA from RNA (see [Reverse Transcription](https://www.sigmaaldrich.com/US/en/technical-documents/technical-article/genomics/gene-expression-and-silencing/reverse-transcription) for details of RT evaluation). ### Taq DNA Polymerase As with selecting the most appropriate reverse transcriptase for the RT, selection of the appropriate polymerase enzyme is vital. A fundamental problem with natural Taq DNA polymerase is that the enzyme has residual activity at low temperature. Nonspecific primer binding leads to nonspecific product formation as a result of this residual polymerase activity. Antibody-blocked or chemically blocked Taq DNA polymerases (‘hot start’) help to rectify this situation by preventing enzyme activity until the high-temperature, denaturation step begins. ### Buffer Buffers or reaction master mixes, typically contain dNTPs, a Taq DNA polymerase, MgCl2 and stabilizers. SYBR Green I dye, ROX™, fluorescein and inert loading dyes may also be included (Loading Control Dyes), depending on the detection chemistry, instrument and reaction requirements. The PCR buffer components and stabilizers are typically proprietary to the manufacturer. If purchased separately, maximum flexibility is possible, since each ingredient can be optimized individually in the reaction. However, in contrast, while purchasing the ingredients together as a master mix reduces flexibility, it increases batch consistency and convenience while reducing the number of pipetting steps and hence, the chances of error and contamination. ### Loading Control Dyes Some real-time PCR thermal cyclers require a loading dye such as ROX to be included into each reaction to control for variability in the optical system and to normalize differences in signal intensity. Likewise, some thermal cyclers require an initial fluorescein signal to create a virtual background when working with SYBR Green I dye assays (which have very low background). These may be supplied in the master mix or as separate components so that the appropriate concentration can be used. ## [](https://www.sigmaaldrich.com)The MIQE Guidelines One clear problem with the use of qPCR is that it is very easy to produce numbers that can then readily be interpreted as quantitative results. However, this can be equally misleading because quality control and further analysis may be required to differentiate between potential artifacts caused by inappropriate assay design, execution, or data analysis. The publication of apparently significant data without adequate quality controls has led to reports that are, at best, not biologically or clinically relevant and, at worst, are inaccurate. Each step of the qPCR experimental process, from sample acquisition to qPCR data analysis, is vulnerable to variability6. Therefore, variability may occur during sample selection and processing, extraction of nucleic acids (can result in differences in quality which cause lack of reproducibility of qPCR target detection), assay design and optimization (contribute to differences in assay efficiency and sensitivity) and data analysis (requires some subjective interpretation and application of appropriate statistical methods). It is critical that the information provided to a scientific audience contains adequate information for the experiment to be critically assessed7, yet it is apparent that this is not always the case8. The “Minimum Information for Publication of Quantitative Real-time PCR Experiments” (MIQE) guidelines9 address these concerns. The aims of the MIQE guidelines are to increase transparency by specifying the minimum information about an assay that is required for the reader to be able to assess the technical validity of a publication and to provide guidance for design, optimization and validation of new qPCR assays. MIQE consists of nine sections (experimental design, sample, nucleic acids, reverse transcription, target, primers and probes, assay details, PCR cycling and data analysis; visit our MIQE page to download a checklist, __Table 1__). All parameters relate to information that should be obtained during the process of experimental design, optimization and validation. When using commercial assays or those from the published literature, optimization and validation should still be executed. The MIQE paper includes a checklist with factors labeled Essential, which are considered indispensable for an adequate description of the qPCR assay, whereas other components are labeled Desirable, indicating that this information is useful but even without it, the assay could be replicated and the data within the publication evaluated. It is important to recognize that reporting PCR efficiency, analytical sensitivity and specificity of each individual assay is essential and should be determined by the investigator using the conditions in the laboratory. There are specific considerations when performing digital PCR (see [Digital PCR](https://www.sigmaaldrich.com/US/en/technical-documents/protocol/genomics/pcr/digital-pcr)) that have been addressed in a recent digital PCR MIQE publication10. ## [](https://www.sigmaaldrich.com)Are You MIQE Compliant? __Minimum Information for Publication of Quantitative Real-time PCR Experiments__ | | | |----------------------------------------------------------------------|-------------| | The MIQE Checklist for qPCRa | Importanceb | | __Experimental Design__ | | | Definition of experimental and control group | Essential | | Number within each group | Essential | | Assay carried out by core lab or investigator's lab? | Desirable | | Acknowledgement of authors' contributions | Desirable | | __Sample__ | | | Description | Essential | | Volume/mass of sample processed | Desirable | | Microdissection or macrodissection | Essential | | Processing procedure | Essential | | If frozen - how and how quickly? | Essential | | If fixed - with what, how quickly? | Essential | | Sample storage conditions and duration (especially for FFPE samples) | Essential | | __Nudeic Acid Extraction__ | | | Procedure and/or instrumentation | Essential | | Name of kit and details of any modifications | Essential | | Source of additional reagents used | Desirable | | Details of DNase or RNAse treatment | Essential | | Contamination assessment (DNA or RNA) | Essential | | Nucleic acid quantification | Essential | | Instrument and method | Essential | | Purity (A200/A200) | Desirable | | Yield | Desirable | | RNA integrity method/instrument | Essential | | RIN/RQI or Co of 3' and S' transcripts | Essential | | Electrophoresis traces | Desirable | | Inhibition testing (Co dilutions, spike or other) | Essential | | __Revers Transcription__ | | | Complete reaction conditions | Essential | | Amount of RNA and reaction volume | Essential | | Priming oligonucleotide (if using GPS) and concentration | Essential | | Revers transcriptase and cocentration | Essential | | Temperature and time | Essential | | Manufacture of reagents and catalogue numbers | Desirable | | 6Cqs with and without RT | Desirable | | Storage conditions of cDNA | Desirable | | __qPCR Target Information__ | | | If multiplex, efficiency and LOD of each assay | Essential | | Sequence accession number | Essential | | Loction of amplicon | Desirable | | Amplicon length | Essential | | In Silico specificity screen (BLAST,etc) | Essential | | Pseudogenes, retropseudogenes of other homologs? | Desirable | | Sequence alignment | Essential | | Loction of each primer by exon or intron (if applicable) | Essential | | What splice variants are targeted? | Essential | | __qPCR Oligonucleotides__ | | | Primer sequences | Essential | | RTPrimerDB Identification Number | Desirable | | dProbe sequences | Desirable | | Location and identity of any modifications | Essential | | Manufacture of oligonucleotides | Desirable | | Purification method | Desirable | Table 1The MIQE Guidelines Checklist | | | |----------------------------------------------------------|-------------| | The MIQE Checklist for qPCRa | Importanceb | | __qPCR Protocol__ | | | Complete reaction conditions | Essential | | reaction Volume and amount of cDNA/DNA | Essential | | Primer, (probe),Mg\** and dNTP concentrations | Essential | | Polymerase identity and concentration | Essential | | Buffer/kit identity and manufacturer | Essential | | Exact chemical constitution of the buffer | Desirable | | Additives (SYBR Green i, DMSO,etc) | Essential | | Manufactue of plates/tubes and catalog number | Desirable | | complete thermocycling parameters | Essential | | Reaction setup (manual/robotic) | Desirable | | Manufactue of qPCR instrument | Essential | | __qPCR Validation__ | | | Evidence of optimization (from gradients | Desirable | | Specificity (gel, sequence, melt, or digest) | Essential | | For SYBR Green l, Co of the NTC | Essential | | Standard curves with slpoe and y-intercept | Essential | | PCR efficiency calculated from slope | Essential | | Confudence interval for PCR efficiency or standard error | Desirable | | R2 of standard curve | Essential | | Linear dynamic range | Essential | | Cq variation at lower limit | Essential | | Confidence intervals throughout range | Desirable | | Evidence for limit of detection | Essential | | If multiplex, efficiency and LOD of each assay | Essential | | __Data Analysis__ | | | qPCR analysis program (source, version) | Essential | | Cq method determination | Essential | | Outlier identification and disposition | Essential | | Results of NTCs | Essential | | Justification of number and choice of reference genes | Essential | | Description of normalization method | Essential | | Number and concordance of biological replicates | Desirable | | number and stage (RT or qPCR) of technical replicates | Essential | | Repeatability (intra-assay variation) | Essential | | Reproducibility (intra-assay variation, %CV) | Desirable | | Power analysis | Desirable | | Statistical methods for result significance | Essential | | Software (source, version) | Essential | | Cq or raw data submission using RDML | Desirable | aClinical chemical Copyright 2009 by American Association For Clinical Chemistry, Inc. Reproduced with permission of American Association For Clinical Chemistry, Inc. in the format Internet posting via Copyright Clearance center. bAll essential information must be submitted with the manuscript, Desirable information should be submitted if available. If primers are from RTPrimerDB, information on qPCR target, oligonucleotides, protocols, and validation is available from that source. cAssessing the absence of DNA using a no-revers transcription assay is essential when first extracting RNA. Once the sample has been validated as DNA,free, inclusion of no-revers transcription control is desirable but no longer essential. dDisclosure of the probe sequence is highly desirable and strongly encourage. However, because all not commercial pre-designed assay vendors provides this information, it cannot be an essential requirement. Use of such assays is discouraged. ## Materials Sorry, an unexpected error has occurred Response not successful: Received status code 500 ### References 1\. Benes V, Castoldi M. 2010. Expression profiling of microRNA using real-time quantitative PCR, how to use it and what is available. Methods. 50(4):244-249. [https://doi.org/10.1016/j.ymeth.2010.01.026](https://doi.org/10.1016/j.ymeth.2010.01.026) 2\. Nolan T, Bustin SA. 2013. PCR Technology: Current Innovations. 3. CRC Press: 3\. Chen C. 2005. Real-time quantification of microRNAs by stem-loop RT-PCR. Nucleic Acids Research. 33(20):e179-e179. [https://doi.org/10.1093/nar/gni178](https://doi.org/10.1093/nar/gni178) 4\. Shi R, Chiang VL. 2005. Facile means for quantifying microRNA expression by real-time PCR. BioTechniques. 39(4):519-525. [https://doi.org/10.2144/000112010](https://doi.org/10.2144/000112010) 5\. Tang F. 2006. MicroRNA expression profiling of single whole embryonic stem cells. Nucleic Acids Research. 34(2):e9-e9. [https://doi.org/10.1093/nar/gnj009](https://doi.org/10.1093/nar/gnj009) 6\. Nolan T, Hands RE, Bustin SA. 2006. Quantification of mRNA using real-time RT-PCR. Nat Protoc. 1(3):1559-1582. [https://doi.org/10.1038/nprot.2006.236](https://doi.org/10.1038/nprot.2006.236) 7\. Bustin SA. 2010. Why the need for qPCR publication guidelines??The case for MIQE. Methods. 50(4):217-226. [https://doi.org/10.1016/j.ymeth.2009.12.006](https://doi.org/10.1016/j.ymeth.2009.12.006) 8\. Huggett J, Bustin SA. 2011. Standardisation and reporting for nucleic acid quantification. Accred Qual Assur. 16(8-9):399-405. [https://doi.org/10.1007/s00769-011-0769-y](https://doi.org/10.1007/s00769-011-0769-y) 9\. Bustin SA, Benes V, Garson JA, Hellemans J, Huggett J, Kubista M, Mueller R, Nolan T, Pfaffl MW, Shipley GL, et al. 2009. The MIQE Guidelines: Minimum Information for Publication of Quantitative Real-Time PCR Experiments. 55(4):611-622. [https://doi.org/10.1373/clinchem.2008.112797](https://doi.org/10.1373/clinchem.2008.112797) 10\. Huggett JF, Foy CA, Benes V, Emslie K, Garson JA, Haynes R, Hellemans J, Kubista M, Mueller RD, Nolan T, et al. 2013. The Digital MIQE Guidelines: Minimum Information for Publication of Quantitative Digital PCR Experiments. 59(6):892-902. [https://doi.org/10.1373/clinchem.2013.206375](https://doi.org/10.1373/clinchem.2013.206375) __Related Articles__ - [How qPCR Works](https://www.sigmaaldrich.com/US/en/technical-documents/technical-article/genomics/qpcr/how-qpcr-works) - [PCR/qPCR/dPCR Assay Design](https://www.sigmaaldrich.com/US/en/technical-documents/protocol/genomics/pcr/pcr-qpcr-dpcr-assay-design) - [Mgat4 May Play a Role in Increased Sialylation by Overexpressing Functional MGAT1 in Mgat1-Disrupted Chinese Hamster Ovary (CHO) Cells](https://www.sigmaaldrich.com/US/en/technical-documents/technical-article/genomics/cloning-and-expression/mgat1-disrupted-chinese-hamster-ovary-cells) - [Complete Solutions for PCR Assay Development](https://www.sigmaaldrich.com/US/en/technical-documents/technical-article/genomics/dna-and-rna-purification/pcr-assay-development) - [Water for Next-Generation Sequencing](https://www.sigmaaldrich.com/US/en/technical-documents/technical-article/genomics/next-gen-sequencing/water-for-next-generation-sequencing) - [PCR Assay Optimization and Validation](https://www.sigmaaldrich.com/US/en/technical-documents/technical-article/genomics/pcr/assay-optimization-and-validation) - [DNA Oligonucleotide Synthesis](https://www.sigmaaldrich.com/US/en/technical-documents/technical-article/genomics/pcr/dna-oligonucleotide-synthesis) - [Locked Nucleic Acid & Minor Groove Binder / Eclipse Dark Quencher](https://www.sigmaaldrich.com/US/en/technical-documents/technical-article/genomics/pcr/locked-nucleic-acids-faq) - [View More](https://www.sigmaaldrich.com/US/en/search/facet-search?focus=sitecontent&term=facet-search) Top __Sign In To Continue__ To continue reading please sign in or create an account. Sign In__Don't Have An Account?__Register Support[Customer Support](https://www.sigmaaldrich.com/US/en/support/customer-support)[Contact Us](https://www.sigmaaldrich.com/US/en/collections/offices)[FAQ](https://maestro.my.site.com/knowledgeportal/s/)[Safety Data Sheets (SDS)](https://www.sigmaaldrich.com/US/en/documents-search?tab=sds)[Certificates (COA/COO)](https://www.sigmaaldrich.com/US/en/documents-search?tab=coa)[Quality & Regulatory](https://www.sigmaaldrich.com/US/en/life-science/quality-and-regulatory-management)[Calculators & Apps](https://www.sigmaaldrich.com/US/en/support/calculators-and-apps)[Webinars](https://www.sigmaaldrich.com/US/en/collections/webinars) Orders[Order Lookup](https://www.sigmaaldrich.com/US/en/order-lookup)[Quick Order](https://www.sigmaaldrich.com/US/en/quick-order)[Custom Products](https://www.sigmaaldrich.com/US/en/services/custom-products)[eCommerce Solutions](https://www.sigmaaldrich.com/US/en/life-science/ecommerce/ecommerce-solutions) Company[About Us](https://www.sigmaaldrich.com/US/en/life-science/about-us)[Responsibility](https://www.sigmaaldrich.com/US/en/life-science/ssbi)[Events](https://www.sigmaaldrich.com/US/en/collections/events)[Press Releases](https://www.sigmaaldrich.com/US/en/collections/press)[Programs](https://www.sigmaaldrich.com/US/en/life-science/partnership-programs)[Careers](https://careers.merckgroup.com/global/en)[Offices](https://www.sigmaaldrich.com/US/en/collections/offices) Social Media [![LinkedIn icon](https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/images/icons/linkedin.svg)](https://www.linkedin.com/company/milliporesigma) [![X icon](https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/images/icons/x-icon.svg)](https://x.com/MilliporeSigma) [![Facebook Icon](https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/images/icons/facebook.svg)](https://www.facebook.com/MilliporeSigma) [![Instagram Icon](https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/images/icons/instagram.svg)](https://www.instagram.com/milliporesigma/) [![YouTube Icon](https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/images/icons/youtube.svg)](https://www.youtube.com/@milliporesigma2407/featured) MilliporeSigma __Research. Development. Production.__ We are a leading supplier to the global Life Science industry with solutions and services for research, biotechnology development and production, and pharmaceutical drug therapy development and production. [![Vibrant M string](https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/images/icons/vibrant-m-string-1-rrvcrp.svg)](https://www.sigmaaldrich.com/US/en) [Sigma-Aldrich® Solutions](https://www.sigmaaldrich.com/US/en/life-science/sigma-aldrich)[BioReliance® Solutions](https://www.sigmaaldrich.com/US/en/life-science/bioreliance)[Millipore® Solutions](https://www.sigmaaldrich.com/US/en/life-science/millipore)[SAFC® Solutions](https://www.sigmaaldrich.com/US/en/life-science/safc)[Milli-Q® Solutions](https://www.sigmaaldrich.com/US/en/life-science/milliq)[Supelco® Solutions](https://www.sigmaaldrich.com/US/en/life-science/supelco) © 2026 Merck KGaA, Darmstadt, Germany and/or its affiliates. All Rights Reserved, including Text and Data Mining for AI training and similar technologies. Reproduction of any materials from the site is strictly forbidden without permission. [Site Use Terms](https://www.sigmaaldrich.com/US/en/life-science/legal/site-use-terms)|[Privacy Policy](https://www.sigmaaldrich.com/US/en/life-science/legal/privacy-statement)|[General Terms and Conditions of Sale](https://www.sigmaaldrich.com/US/en/life-science/legal/terms-and-conditions)|[Copyright Consent](https://www.sigmaaldrich.com/US/en/life-science/legal/copyright-consent) |[Site Map](https://www.sigmaaldrich.com/US/en/site-map) An unknown error has occured. - English - EN - Español - ES [Learn More](https://www.sigmaaldrich.com) - Products - [Analytical Chemistry](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry) - [Analytical Chromatography](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/analytical-chromatography) - [Analytical Syringes](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/analytical-chromatography/analytical-syringes) - [Analytical Vials](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/analytical-chromatography/analytical-vials) - [Carbon Adsorbents](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/analytical-chromatography/carbon-adsorbents) - [Chromatography Standards](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/reference-materials/chromatography-standards) - [GC Columns, Accessories & Adsorbents](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/analytical-chromatography/gc-columns-accessories-and-adsorbents) - [HPLC Buffers](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/analytical-chromatography/hplc-buffers) - [HPLC Columns](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/analytical-chromatography/hplc-columns) - [LPLC Media & Accessories](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/analytical-chromatography/lplc-media-and-accessories) - [Purge Traps](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/analytical-sample-preparation/purge-traps) - [Solvents](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/analytical-chromatography/solvents) - [TLC Plates & Adsorbents](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/analytical-chromatography/tlc-plates-and-adsorbants) - [Analytical Reagents](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/analytical-reagents) - [Acids](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/lab-chemicals/acids) - [Analytical Syringes](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/analytical-chromatography/analytical-syringes) - [Analytical Vials](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/analytical-chromatography/analytical-vials) - [Caustic Alkalis & Bases](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/lab-chemicals/caustic-alkalis-and-bases) - [Chromatography & Spectroscopy Reagents](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/analytical-reagents/chromatography-spectroscopy-reagents) - [Colorimetric & Titrimetric Test Kits](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/photometry-and-rapid-chemical-testing/colorimetric-and-titrimetric-test-kits) - [Indicators](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/analytical-reagents/indicators) - [Karl Fischer Reagents](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/analytical-reagents/karl-fischer-reagents) - [Karl Fischer Standards](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/reference-materials/karl-fischer-standards) - [Metals](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/lab-chemicals/metals) - [pH Test Strips, pH Papers, Readers & Accessories](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/photometry-and-rapid-chemical-testing/ph-test-strips-paper-readers-and-accessories) - [Salts](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/lab-chemicals/salts) - [Solvents](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/analytical-chromatography/solvents) - [Spectroquant Photometry Instruments, Kits, & Accessories](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/photometry-and-rapid-chemical-testing/photometry-instruments-kits-and-accessories) - [Test Strips, Papers & Readers](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/photometry-and-rapid-chemical-testing/test-strips-papers-and-readers) - [Titration Reagents](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/analytical-reagents/titration-reagents) - [Analytical Sample Preparation](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/analytical-sample-preparation) - [Air Monitoring Devices & Tubes](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/analytical-sample-preparation/air-monitoring-devices-and-tubes) - [Laboratory Filter Holders](https://www.sigmaaldrich.com/US/en/products/filtration/laboratory-filter-holders) - [Millipore<sup>®</sup> Lab Filter Membranes](https://www.sigmaaldrich.com/US/en/products/filtration/laboratory-filter-membranes/millipore-filter-membranes) - [Millex<sup>®</sup> Syringe Filters](https://www.sigmaaldrich.com/US/en/products/filtration/laboratory-syringe-filters/millex-syringe-filters) - [Purge Traps](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/analytical-sample-preparation/purge-traps) - [Solid Phase Extraction (SPE) & QuEChERS](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/analytical-sample-preparation/spe-and-quechers) - [Solid Phase Micro-Extraction (SPME)](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/analytical-sample-preparation/spme-fibers-and-accessories) - [Supported Liquid Extraction (SLE) Columns, Resins & Accessories](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/analytical-sample-preparation/sle-columns-resins-and-accessories) - [Lab Safety](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/lab-safety) - [Labware Detergents & Cleaners](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/lab-safety/cleaning-detergents) - [Safe Handling](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/lab-safety/safe-handling) - [Safety Accessories](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/lab-safety/safety-accessories) - [Spillage Absorption](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/lab-safety/spillage-absorption) - [Photometry & Rapid Chemical Testing](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/photometry-and-rapid-chemical-testing) - [Colorimetric & Titrimetric Test Kits](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/photometry-and-rapid-chemical-testing/colorimetric-and-titrimetric-test-kits) - [pH Test Strips, pH Papers, Readers & Accessories](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/photometry-and-rapid-chemical-testing/ph-test-strips-paper-readers-and-accessories) - [Photometry Instruments, Test Kits & Accessories](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/photometry-and-rapid-chemical-testing/photometry-instruments-kits-and-accessories) - [Test Strips, Papers & Readers](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/photometry-and-rapid-chemical-testing/test-strips-papers-and-readers) - [Turbidimetric Analysis](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/photometry-and-rapid-chemical-testing/turbiquant-turbidimetric-analysis) - [Reference Materials](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/reference-materials) - [Amino Acid, Peptide & Protein Standards](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/reference-materials/amino-acid-peptide-and-protein-standards) - [Biomarker & Metabolite Standards](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/reference-materials/biomarker-and-metabolite-standards) - [Cannabis Standards](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/reference-materials/cannabis-standards) - [Carbohydrate Standards](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/reference-materials/carbohydrate-standards) - [Certified Reference Materials](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/reference-materials/certified-reference-materials) - [Chromatography Standards](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/reference-materials/chromatography-standards) - [Food Additive Standards](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/reference-materials/food-additive-standards) - [Food & Cosmetic Component Standards](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/reference-materials/food-and-cosmetic-component-standards) - [ICP & AAS Standards](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/reference-materials/icp-and-aas-standards) - [Inorganic Elemental Impurity Mix Standards](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/reference-materials/inorganic-elemental-impurity-mix-standards) - [Ion Chromatography Standards](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/reference-materials/ion-chromatography-standards) - [Karl Fischer Standards](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/reference-materials/karl-fischer-standards) - [Lipid Standards](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/reference-materials/lipid-standards) - [Matrix Materials Standards](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/reference-materials/matrix-materials-standards) - [Microbiology Standards](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/reference-materials/microbiology-standards) - [Organic Pollutant Standards](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/reference-materials/organic-pollutant-standards) - [Pesticide Standards](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/reference-materials/pesticide-standards) - [Petrochemical Standards](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/reference-materials/petrochemical-standards) - [Pharma Standards](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/reference-materials/pharma-secondary-standards) - [Pharmaceuticals, Illicit Drugs & Diagnostic Biomarkers](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/reference-materials/pharmaceuticals-illicit-drugs-and-diagnostic-biomarkers) - [Pharmacopeia & Metrological Institutes Standards](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/reference-materials/pharmacopeia-and-metrological-institutes-standards) - [Physical & Chemical Properties Standards](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/reference-materials/physical-property-standards) - [Phytochemical Standards](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/reference-materials/phytochemical-standards) - [Vitamin Standards](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/reference-materials/vitamin-standards) - [Cell Culture & Analysis](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis) - [3D Cell Culture](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/3d-cell-culture) - [Hydrogels](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/3d-cell-culture/hydrogels) - [Organoids](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/3d-cell-culture/organoids) - [Scaffolds](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/3d-cell-culture/scaffolds) - [Animal Component Free Cell Culture Reagents](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/animal-component-free-cell-culture-reagents) - [Cell Analysis](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/cell-analysis) - [Cell Counting Equipment](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/cell-analysis/cell-counting-equipment) - [Cell Health Analysis](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/cell-analysis/cell-health-analysis) - [Cell Imaging Instruments](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/cell-analysis/cell-imaging-instruments) - [Cell Isolation Kits](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/cell-analysis/cell-isolation-kits) - [Cell Migration & Invasion Assays](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/cell-analysis/cell-migration-and-invasion-assays) - [Live Cell Imaging Reagents](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/cell-analysis/live-cell-imaging-reagents) - [Cell Culture Media & Buffers](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/cell-culture-media-and-buffers) - [Bioprocessing Cell Culture Media](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/bioprocessing-cell-culture/bioprocessing-cell-culture-media) - [Bioprocessing Liquid Cell Culture Media & Buffers](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/bioprocessing-formulation-raw-materials/liquid-cell-culture-media-buffers) - [Classical Media & Buffers](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/cell-culture-media-and-buffers/classical-media-and-buffers) - [Custom GMP Cell Culture Media](https://www.sigmaaldrich.com/US/en/services/custom-products/custom-gmp-cell-culture-products) - [Plant Culture Media](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/cell-culture-media-and-buffers/plant-culture-media) - [Cell Culture Supplements & Reagents](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/cell-culture-supplements-and-reagents) - [Albumins & Transport Proteins](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/cell-culture-supplements-and-reagents/albumins-and-transport-proteins) - [Amino Acids](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/biochemicals/amino-acids) - [Antibiotics](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/biochemicals/antibiotics) - [Attachment Factors](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/cell-culture-supplements-and-reagents/attachment-factors) - [Bioprocessing Recombinant Supplements](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/bioprocessing-cell-culture/recombinant-supplements) - [Carbohydrates](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/biochemicals/carbohydrates) - [Cell Dissociation Reagents](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/cell-culture-supplements-and-reagents/cell-dissociation-reagents) - [Cell Freezing Reagents](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/cell-culture-supplements-and-reagents/cell-freezing-reagents) - [FBS](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/cell-culture-supplements-and-reagents/fbs) - [Growth Factors & Cytokines](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/cell-culture-supplements-and-reagents/growth-factors-and-cytokines) - [Hormones](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/cell-culture-supplements-and-reagents/hormones) - [Human Serum](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/cell-culture-supplements-and-reagents/human-serum) - [(Other) Sera](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/cell-culture-supplements-and-reagents/other-sera) - [Plant Culture Reagents](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/cell-culture-supplements-and-reagents/plant-culture-reagents) - [Sera](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/cell-culture-supplements-and-reagents/sera) - [Supplements for Cell Culture](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/cell-culture-supplements-and-reagents/supplements) - [Vitamins](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/biochemicals/vitamins) - [Cell Lines & Specialty Cell Culture](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/cell-lines-and-specialty-cell-culture) - [Bioprocessing Cell Lines](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/bioprocessing-cell-culture/bioprocessing-cell-lines) - [Mammalian Cell Lines](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/cell-lines-and-specialty-cell-culture/mammalian-cell-lines) - [Mouse Embryo Media](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/cell-lines-and-specialty-cell-culture/mouse-embryo-media) - [Primary Cells](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/cell-lines-and-specialty-cell-culture/primary-cells) - [Stem Cells](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/cell-lines-and-specialty-cell-culture/stem-cells) - [Sterile Lab Media Filtration & Cultureware](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/sterile-lab-media-filtration-and-cultureware) - [Cell Culture Supplies](https://www.sigmaaldrich.com/US/en/products/labware/cell-culture-and-cryogenics/cell-culture-supplies) - [Millex<sup>®</sup> Syringe Filters](https://www.sigmaaldrich.com/US/en/products/filtration/laboratory-syringe-filters/millex-syringe-filters) - [Millicell<sup>®</sup> Cell Culture Inserts & Plates](https://www.sigmaaldrich.com/US/en/products/labware/cell-culture-and-cryogenics/millicell-cell-culture-inserts-and-plates) - [Millipore<sup>®</sup> Sterile Filters](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/sterile-lab-media-filtration-and-cultureware/millipore-sterile-filters) - [MultiScreen<sup>®</sup> Filter Plates](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/sterile-lab-media-filtration-and-cultureware/multiscreen-filter-plates) - [Stericup<sup>®</sup> Vacuum Filters](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/sterile-lab-media-filtration-and-cultureware/stericup-vacuum-filtration) - [Chemistry & Biochemicals](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals) - [Amino Acids, Resins & Reagents for Peptide Synthesis](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/amino-acids-resins-and-reagents-for-peptide-synthesis) - [Biochemicals](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/biochemicals) - [Agarose](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/biochemicals/agarose) - [Amino Acids](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/biochemicals/amino-acids) - [Antibiotics](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/biochemicals/antibiotics) - [Avanti Research™, A Croda Brand](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/biochemicals/avanti-research) - [Biological Buffers](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/biochemicals/biological-buffers) - [Carbohydrates](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/biochemicals/carbohydrates) - [Chelating & Reducing Agents](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/biochemicals/chelating-reducing-agents) - [Coenzymes](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/biochemicals/coenzymes) - [Detergents](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/biochemicals/detergents) - [Lipids](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/biochemicals/lipids) - [Glycoconjugates](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/biochemicals/glycoconjugates) - [High-Purity Biochemicals & Reagents](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/biochemicals/high-purity-biochemicals-and-reagents) - [Metabolism Assay Kits](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/biochemicals/metabolism-assay-kits) - [Metabolite Libraries](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/biochemicals/metabolite-libraries) - [Natural Products](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/biochemicals/natural-products) - [Nucleosides & Nucleotides](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/biochemicals/nucleosides-and-nucleotides) - [Vitamins](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/biochemicals/vitamins) - [Building Blocks](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/building-blocks) - [Fluorinated Building Blocks](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/building-blocks/fluorinated-building-blocks) - [Halogenated Heterocycles](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/building-blocks/halogenated-heterocycles) - [Heterocyclic Building Blocks](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/building-blocks/heterocyclic-building-blocks) - [Organic Building Blocks](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/building-blocks/organic-building-blocks) - [Catalysts](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/catalysts) - [Buchwald Catalysts & Ligands](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/catalysts/buchwald-catalysts-and-ligands) - [C-H Activation Catalysts](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/catalysts/c-h-activation-catalysts) - [Chiral Catalysts & Ligands](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/catalysts/chiral-catalysts-and-ligands) - [Cross-Coupling Catalysts](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/catalysts/cross-coupling-catalysts) - [Hydrogenation Catalysts](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/catalysts/hydrogenation-catalysts) - [Inorganic Catalysts](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/catalysts/inorganic-catalysts) - [NHC Ligands & Complexes](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/catalysts/nhc-ligands-and-complexes) - [Olefin Metathesis](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/catalysts/olefin-metathesis) - [Organocatalysts](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/catalysts/organocatalysts) - [Phase-Transfer Catalysts](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/catalysts/phase-transfer-catalysts) - [Phosphine Ligands](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/catalysts/phosphine-ligands) - [Photocatalysts](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/catalysts/photocatalysts) - [Transition Metal Catalysts](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/catalysts/transition-metal-catalysts) - [Chemical Biology](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/chemical-biology) - [Carbohydrates](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/biochemicals/carbohydrates) - [Chemical Biology Tools](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/chemical-biology/chemical-biology-tools) - [Click Chemistry Reagents](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/chemical-biology/click-chemistry-reagents) - [Crosslinkers](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/chemical-biology/crosslinkers) - [Protein Degrader Building Blocks](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/chemical-biology/protein-degrader-building-blocks) - [Chemical Synthesis](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/chemical-synthesis) - [Boronic Acids & Derivatives](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/chemical-synthesis/boronic-acids-and-derivatives) - [C-C Bond Forming Reagents](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/chemical-synthesis/c-c-bond-forming-reagents) - [Chiral Auxiliaries](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/chemical-synthesis/chiral-auxiliaries) - [Coupling Reagents & Nucleosides](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/chemical-synthesis/coupling-reagents-and-nucleosides) - [Grignard Reagents](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/chemical-synthesis/grignard-reagents) - [Halogenation Reagents](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/chemical-synthesis/halogenation-reagents) - [Organoaluminum Reagents](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/chemical-synthesis/organoaluminum-reagents) - [Organolithium Reagents](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/chemical-synthesis/organolithium-reagents) - [Organosilicon Reagents](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/chemical-synthesis/organosilicon-reagents) - [Organotin Reagents](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/chemical-synthesis/organotin-reagents) - [Organozinc Reagents](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/chemical-synthesis/organozinc-reagents) - [Oxidation Reagents](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/chemical-synthesis/oxidation-reagents) - [Protection/Deprotection Reagents](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/chemical-synthesis/protection-deprotection-reagents) - [Reducing Agents](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/chemical-synthesis/reducing-agents) - [Flavors & Fragrances](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/flavors-and-fragrances) - [Formulation](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/formulation) - [Biomolecule Formulation](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/formulation/biomolecule-formulation) - [Granulated Materials](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/formulation/granulated-materials) - [Liquid Formulation](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/formulation/liquid-formulation) - [Protein Stabilizers](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/formulation/protein-stabilizers) - [Semisolid Formulation](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/formulation/semisolid-formulation) - [Solid Formulation](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/formulation/solid-formulation) - [Lab Chemicals](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/lab-chemicals) - [Absorbents & Adsorbents](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/lab-chemicals/absorbents-and-adsorbents) - [Acids](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/lab-chemicals/acids) - [Caustic Alkalis & Bases](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/lab-chemicals/caustic-alkalis-and-bases) - [Drying Agents](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/lab-chemicals/drying-agents) - [Filter Aids & Filter Media](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/lab-chemicals/filter-aids-filter-media) - [Indicators](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/analytical-reagents/indicators) - [Metals](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/lab-chemicals/metals) - [Salts](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/lab-chemicals/salts) - [Solvents](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/analytical-chromatography/solvents) - [Lab Safety](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/lab-safety) - [Labware Detergents & Cleaners](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/lab-safety/cleaning-detergents) - [Safe Handling](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/lab-safety/safe-handling) - [Safety Accessories](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/lab-safety/safety-accessories) - [Spillage Absorption](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/lab-safety/spillage-absorption) - [Stable Isotopes](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/stable-isotopes) - [Synthesis Enabling Tools](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/synthesis-enabling-tools) - [Automated Chemical Synthesis](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/synthesis-enabling-tools/automated-chemical-synthesis) - [High Throughput Screening](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/synthesis-enabling-tools/high-throughput-screening-platform) - [Photoreactors](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/synthesis-enabling-tools/photoreactors) - [Electrosynthesis](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/synthesis-enabling-tools/electrosynthesis-platform) - [Clinical & Diagnostics](https://www.sigmaaldrich.com/US/en/products/clinical-diagnostics) - [Blood Typing](https://www.sigmaaldrich.com/US/en/products/clinical-diagnostics/blood-typing) - [Blood Typing Finished Reagents](https://www.sigmaaldrich.com/US/en/products/clinical-diagnostics/blood-typing/blood-typing-finished-reagents) - [Blood Typing Intermediates For Further Manufacturing Use (FFMU)](https://www.sigmaaldrich.com/US/en/products/clinical-diagnostics/blood-typing/blood-typing-intermediates) - [Cell Marque™](https://www.sigmaaldrich.com/US/en/products/clinical-diagnostics/cell-marque) - [Cell Marque™ Control Slides](https://www.sigmaaldrich.com/US/en/products/clinical-diagnostics/cell-marque/cell-marque-control-slides) - [Cell Marque™ Detection Systems & Ancillary Reagents](https://www.sigmaaldrich.com/US/en/products/clinical-diagnostics/cell-marque/cell-marque-detection-systems-and-ancillary-reagents) - [Cell Marque™ Primary Antibodies](https://www.sigmaaldrich.com/US/en/products/clinical-diagnostics/cell-marque/cell-marque-ihc-antibodies) - [Lateral Flow Membranes](https://www.sigmaaldrich.com/US/en/products/clinical-diagnostics/lateral-flow-membranes) - [ProClin™ Preservatives](https://www.sigmaaldrich.com/US/en/products/clinical-diagnostics/proclin-preservatives) - [Tissue Diagnostics](https://www.sigmaaldrich.com/US/en/products/clinical-diagnostics/tissue-diagnostics) - [Bacteriology Stains](https://www.sigmaaldrich.com/US/en/products/clinical-diagnostics/tissue-diagnostics/bacteriology-stains) - [Cell Separation Media](https://www.sigmaaldrich.com/US/en/products/clinical-diagnostics/tissue-diagnostics/cell-separation-media) - [Cytology Stains](https://www.sigmaaldrich.com/US/en/products/clinical-diagnostics/tissue-diagnostics/cytology-stains) - [Dry Dyes & Certified Stains](https://www.sigmaaldrich.com/US/en/products/clinical-diagnostics/tissue-diagnostics/dry-dyes-and-certified-stains) - [FISH Probes & Reagents](https://www.sigmaaldrich.com/US/en/products/clinical-diagnostics/tissue-diagnostics/zytovision-in-situ-hybridization-probes) - [Hematology Stains](https://www.sigmaaldrich.com/US/en/products/clinical-diagnostics/tissue-diagnostics/hematology-stains) - [Histology Stains](https://www.sigmaaldrich.com/US/en/products/clinical-diagnostics/tissue-diagnostics/histology-stains) - [Tissue Diagnostics Universal Reagents](https://www.sigmaaldrich.com/US/en/products/clinical-diagnostics/tissue-diagnostics/tissue-diagnostics-universal-reagents) - [Filtration](https://www.sigmaaldrich.com/US/en/products/filtration) - [Concentration Filters](https://www.sigmaaldrich.com/US/en/products/filtration/concentration-filters) - [Amicon<sup>®</sup> Centrifugals](https://www.sigmaaldrich.com/US/en/products/protein-biology/protein-sample-prep/amicon-centrifugals) - [Centrifugal Filters](https://www.sigmaaldrich.com/US/en/products/filtration/concentration-filters/centrifugal-filters) - [Filter Paper](https://www.sigmaaldrich.com/US/en/products/filtration/filter-paper) - [Filtration for Bioprocessing](https://www.sigmaaldrich.com/US/en/products/filtration/filtration-for-bioprocessing) - [Buffer Filtration](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/buffer-media-prep/buffer-filtration) - [Clarification Filter Holders & Systems](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/clarification-harvest/clarification-filter-holders-and-systems-for-bioprocessing) - [Filter Housings](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/sterile-filtration-and-bioburden-control/filter-housings) - [Final Sterile Filtration & Filling](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/sterile-filtration-and-bioburden-control/final-sterile-filtration-and-filling) - [Gas & Vent Filters](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/sterile-filtration-and-bioburden-control/gas-and-vent-filters) - [Integrity Testers](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/sterile-filtration-and-bioburden-control/integrity-testers) - [Media Filtration](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/buffer-media-prep/media-filtration) - [Prefilters & Bioburden Control](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/sterile-filtration-and-bioburden-control/prefilters-and-bioburden-control) - [Sterile Filters](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/sterile-filtration-and-bioburden-control/sterile-filters) - [Virus Filter Holders & Systems](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/viral-clearance/virus-filter-holders-and-systems) - [Virus Filters](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/viral-clearance/virus-filters) - [Laboratory Filter Holders](https://www.sigmaaldrich.com/US/en/products/filtration/laboratory-filter-holders) - [Laboratory Filter Membranes](https://www.sigmaaldrich.com/US/en/products/filtration/laboratory-filter-membranes) - [Filter Membranes](https://www.sigmaaldrich.com/US/en/products/filtration/laboratory-filter-membranes/filter-membranes) - [Millipore<sup>®</sup> Filter Membranes](https://www.sigmaaldrich.com/US/en/products/filtration/laboratory-filter-membranes/millipore-filter-membranes) - [Laboratory Syringe Filters](https://www.sigmaaldrich.com/US/en/products/filtration/laboratory-syringe-filters) - [Syringe Filters](https://www.sigmaaldrich.com/US/en/products/filtration/laboratory-syringe-filters/syringe-filters) - [Millex<sup>®</sup> Syringe Filters](https://www.sigmaaldrich.com/US/en/products/filtration/laboratory-syringe-filters/millex-syringe-filters) - [MultiScreen<sup>®</sup> Filter Plates](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/sterile-lab-media-filtration-and-cultureware/multiscreen-filter-plates) - [Sterile Laboratory Filter Devices](https://www.sigmaaldrich.com/US/en/products/filtration/sterile-laboratory-filter-devices) - [Millipore<sup>®</sup> Sterile Filters](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/sterile-lab-media-filtration-and-cultureware/millipore-sterile-filters) - [Stericup<sup>®</sup> Vacuum Filters](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/sterile-lab-media-filtration-and-cultureware/stericup-vacuum-filtration) - [Vacuum Filters](https://www.sigmaaldrich.com/US/en/products/filtration/vacuum-filters) - [Greener Alternative Products](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/greener-alternative-products) - [Industrial Microbiology](https://www.sigmaaldrich.com/US/en/products/industrial-microbiology) - [Environmental Monitoring & Aseptic Process Simulation](https://www.sigmaaldrich.com/US/en/products/industrial-microbiology/viable-air-samplers) - [Hygiene Monitoring](https://www.sigmaaldrich.com/US/en/products/industrial-microbiology/hygiene-monitoring-instruments-samplers-tests-and-accessories) - [Microbial Culture Media](https://www.sigmaaldrich.com/US/en/products/industrial-microbiology/microbial-culture-media) - [Microbial Culture Media Raw Materials](https://www.sigmaaldrich.com/US/en/products/industrial-microbiology/microbial-culture-media-raw-materials) - [Microbial Filtration](https://www.sigmaaldrich.com/US/en/products/industrial-microbiology/microbial-filtration) - [Microbial Identification Tests & Biochemical Reagents](https://www.sigmaaldrich.com/US/en/products/industrial-microbiology/microbial-identification-tests) - [Microbiology Standards](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/reference-materials/microbiology-standards) - [Pathogen Screening Kits, Instruments, Disposables](https://www.sigmaaldrich.com/US/en/products/industrial-microbiology/pathogen-screening-kits-instuments-and-disposables) - [Pyrogen Testing](https://www.sigmaaldrich.com/US/en/products/industrial-microbiology/pyrogen-testing) - [Quality Indicator Testing Devices](https://www.sigmaaldrich.com/US/en/products/industrial-microbiology/quality-indicator-testing-devices) - [Sterility Testing Consumables, Media & Instruments](https://www.sigmaaldrich.com/US/en/products/industrial-microbiology/sterility-testing-consumables-media-and-filtration) - [Lab Automation](https://www.sigmaaldrich.com/US/en/products/lab-automation) - [AAW™ Automated Assay Workstation](https://www.sigmaaldrich.com/US/en/products/lab-automation/aaw-automated-assay-workstation) - [Labware](https://www.sigmaaldrich.com/US/en/products/labware) - [Cell Culture & Cryogenics](https://www.sigmaaldrich.com/US/en/products/labware/cell-culture-and-cryogenics) - [Cell Culture Supplies](https://www.sigmaaldrich.com/US/en/products/labware/cell-culture-and-cryogenics/cell-culture-supplies) - [Cryo Storage](https://www.sigmaaldrich.com/US/en/products/labware/cryo-storage) - [Millicell<sup>®</sup> Cell Culture Inserts & Plates](https://www.sigmaaldrich.com/US/en/products/labware/cell-culture-and-cryogenics/millicell-cell-culture-inserts-and-plates) - [Filtration](https://www.sigmaaldrich.com/US/en/products/labware/filtration) - [Centrifugal Filters](https://www.sigmaaldrich.com/US/en/products/filtration/concentration-filters/centrifugal-filters) - [Filter Membranes](https://www.sigmaaldrich.com/US/en/products/filtration/laboratory-filter-membranes/filter-membranes) - [Filter Paper](https://www.sigmaaldrich.com/US/en/products/filtration/filter-paper) - [Laboratory Filter Holders](https://www.sigmaaldrich.com/US/en/products/filtration/laboratory-filter-holders) - [Syringe Filters](https://www.sigmaaldrich.com/US/en/products/filtration/laboratory-syringe-filters/syringe-filters) - [Vacuum Filters](https://www.sigmaaldrich.com/US/en/products/filtration/vacuum-filters) - [Amicon<sup>®</sup> Centrifugals](https://www.sigmaaldrich.com/US/en/products/protein-biology/protein-sample-prep/amicon-centrifugals) - [Millex<sup>®</sup> Syringe Filters](https://www.sigmaaldrich.com/US/en/products/filtration/laboratory-syringe-filters/millex-syringe-filters) - [Millipore<sup>®</sup> Filter Membranes](https://www.sigmaaldrich.com/US/en/products/filtration/laboratory-filter-membranes/millipore-filter-membranes) - [Millipore<sup>®</sup> Sterile Filters](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/sterile-lab-media-filtration-and-cultureware/millipore-sterile-filters) - [MultiScreen<sup>®</sup> Filter Plates](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/sterile-lab-media-filtration-and-cultureware/multiscreen-filter-plates) - [Stericup<sup>®</sup> Vacuum Filters](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/sterile-lab-media-filtration-and-cultureware/stericup-vacuum-filtration) - [Glassware](https://www.sigmaaldrich.com/US/en/products/labware/glassware) - [Lab Equipment](https://www.sigmaaldrich.com/US/en/products/labware/laboratory-equipment) - [Balances](https://www.sigmaaldrich.com/US/en/products/labware/laboratory-equipment/laboratory-balances) - [Centrifugation](https://www.sigmaaldrich.com/US/en/products/labware/laboratory-equipment/laboratory-centrifugation) - [Grinders & Homogenizers](https://www.sigmaaldrich.com/US/en/products/labware/sample-handling/grinders-and-homogenizers) - [Laboratory Stirring & Mixing](https://www.sigmaaldrich.com/US/en/products/labware/sample-handling/laboratory-stirring-and-mixing) - [Refrigerators & Freezers](https://www.sigmaaldrich.com/US/en/products/labware/laboratory-equipment/refrigerators-freezers) - [Water Purification](https://www.sigmaaldrich.com/US/en/products/water-purification) - [Labware Partners](https://www.sigmaaldrich.com/US/en/products/labware/labware-partners) - [Benchmark Scientific Products](https://www.sigmaaldrich.com/US/en/products/labware/labware-partners/benchmark-scientific) - [Brand<sup>®</sup> Products](https://www.sigmaaldrich.com/US/en/products/labware/labware-partners/brand) - [Corning<sup>®</sup> Products](https://www.sigmaaldrich.com/US/en/products/labware/labware-partners/corning) - [Cytiva™ Products](https://www.sigmaaldrich.com/US/en/products/labware/labware-partners/cytiva) - [DWK Products](https://www.sigmaaldrich.com/US/en/products/labware/glassware/dwk) - [Eppendorf<sup>®</sup> Products](https://www.sigmaaldrich.com/US/en/products/labware/labware-partners/eppendorf) - [Excel Scientific Products](https://www.sigmaaldrich.com/US/en/products/labware/labware-partners/excel-scientific) - [Heathrow Scientific<sup>®</sup> Products](https://www.sigmaaldrich.com/US/en/products/labware/labware-partners/heathrow-scientific) - [LGC Biosearch™ Products](https://www.sigmaaldrich.com/US/en/products/labware/labware-partners/lgc-biosearch) - [OHAUS<sup>®</sup> Products](https://www.sigmaaldrich.com/US/en/products/labware/labware-partners/ohaus) - [Pop-Bio Products](https://www.sigmaaldrich.com/US/en/products/labware/labware-partners/pop-bio) - [Roche<sup>®</sup> Products](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/roche-life-science-products) - [Liquid Handling & Dispensing](https://www.sigmaaldrich.com/US/en/products/labware/liquid-handling-and-dispensing) - [Microscope Slides & Chambers](https://www.sigmaaldrich.com/US/en/products/labware/microscope-slides-and-chambers) - [PCR Supplies & Equipment](https://www.sigmaaldrich.com/US/en/products/labware/pcr-supplies-and-equipment) - [Plates](https://www.sigmaaldrich.com/US/en/products/labware/plates) - [Millicell<sup>®</sup> Cell Culture Inserts & Plates](https://www.sigmaaldrich.com/US/en/products/labware/cell-culture-and-cryogenics/millicell-cell-culture-inserts-and-plates) - [MultiScreen<sup>®</sup> Filter Plates](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/sterile-lab-media-filtration-and-cultureware/multiscreen-filter-plates) - [MultiScreen<sup>®</sup> Solid Bottom Plates](https://www.sigmaaldrich.com/US/en/products/labware/plates/multiscreen-solid-bottom-plates) - [Sample Handling](https://www.sigmaaldrich.com/US/en/products/labware/sample-handling) - [Grinders & Homogenizers](https://www.sigmaaldrich.com/US/en/products/labware/sample-handling/grinders-and-homogenizers) - [Laboratory Containers & Storage](https://www.sigmaaldrich.com/US/en/products/labware/sample-handling/laboratory-containers-and-storage) - [Laboratory Labels](https://www.sigmaaldrich.com/US/en/products/labware/sample-handling/laboratory-labels) - [Laboratory Sample Collection](https://www.sigmaaldrich.com/US/en/products/labware/sample-handling/laboratory-sample-collection) - [Laboratory Stirring & Mixing](https://www.sigmaaldrich.com/US/en/products/labware/sample-handling/laboratory-stirring-and-mixing) - [Sealing Films, Foils, Tapes](https://www.sigmaaldrich.com/US/en/products/labware/sealing-films-foils-and-tapes) - [Septa](https://www.sigmaaldrich.com/US/en/products/labware/septa) - [Materials Science](https://www.sigmaaldrich.com/US/en/products/materials-science) - [Biomedical Materials](https://www.sigmaaldrich.com/US/en/products/materials-science/biomedical-materials) - [3D Bioprinting](https://www.sigmaaldrich.com/US/en/products/materials-science/biomedical-materials/3d-bioprinting) - [Biomedical Polymers](https://www.sigmaaldrich.com/US/en/products/materials-science/biomedical-materials/biomedical-polymers) - [Drug Delivery Formulation Kits](https://www.sigmaaldrich.com/US/en/products/materials-science/biomedical-materials/drug-delivery-formulation-kits) - [Hydrophilic Polymers](https://www.sigmaaldrich.com/US/en/products/materials-science/biomedical-materials/hydrophilic-polymers) - [Hydrophobic Polymers](https://www.sigmaaldrich.com/US/en/products/materials-science/biomedical-materials/hydrophobic-polymers) - [Polyethylene Glycol (PEGs & PEOs)](https://www.sigmaaldrich.com/US/en/products/materials-science/biomedical-materials/polyethylene-glycol) - [Polymeric Microspheres & Nanoparticles](https://www.sigmaaldrich.com/US/en/products/materials-science/biomedical-materials/polymeric-microspheres-and-nanoparticles) - [Polymerization Tools](https://www.sigmaaldrich.com/US/en/products/materials-science/biomedical-materials/polymerization-tools) - [Electronic Materials](https://www.sigmaaldrich.com/US/en/products/materials-science/electronic-materials) - [Carbon Nanomaterials](https://www.sigmaaldrich.com/US/en/products/materials-science/electronic-materials/carbon-nanomaterials) - [Electronic Chemicals & Etchants](https://www.sigmaaldrich.com/US/en/products/materials-science/electronic-materials/electronic-chemicals-and-etchants) - [Inorganic & Metallic Nanomaterials](https://www.sigmaaldrich.com/US/en/products/materials-science/electronic-materials/inorganic-and-metallic-nanomaterials) - [Liquid Crystals](https://www.sigmaaldrich.com/US/en/products/materials-science/electronic-materials/liquid-crystals) - [OLED & PLED Materials](https://www.sigmaaldrich.com/US/en/products/materials-science/electronic-materials/oled-and-pled-materials) - [OFET & OPV Materials](https://www.sigmaaldrich.com/US/en/products/materials-science/electronic-materials/ofet-and-opv-materials) - [Photonic & Optical Materials](https://www.sigmaaldrich.com/US/en/products/materials-science/electronic-materials/photonic-and-optical-materials) - [Printed Electronic Materials](https://www.sigmaaldrich.com/US/en/products/materials-science/electronic-materials/printed-electronic-materials) - [Self-assembly & Contact Printing](https://www.sigmaaldrich.com/US/en/products/materials-science/electronic-materials/self-assembly-and-contact-printing) - [Silicone Materials](https://www.sigmaaldrich.com/US/en/products/materials-science/electronic-materials/silicone-materials) - [Specialty & Smart Polymers](https://www.sigmaaldrich.com/US/en/products/materials-science/electronic-materials/specialty-and-smart-polymers) - [Substrates & Prefab Electronic Components](https://www.sigmaaldrich.com/US/en/products/materials-science/electronic-materials/substrates-and-prefab-electronic-components) - [Energy Materials](https://www.sigmaaldrich.com/US/en/products/materials-science/energy-materials) - [Battery Materials](https://www.sigmaaldrich.com/US/en/products/materials-science/energy-materials/battery-materials) - [Chalcogenides](https://www.sigmaaldrich.com/US/en/products/materials-science/energy-materials/chalcogenides) - [Fuel Cell Membranes & Materials](https://www.sigmaaldrich.com/US/en/products/materials-science/energy-materials/fuel-cell-membranes-and-materials) - [High-Purity Metals & Alloys](https://www.sigmaaldrich.com/US/en/products/materials-science/energy-materials/high-purity-metals-and-alloys) - [High-Purity Salts](https://www.sigmaaldrich.com/US/en/products/materials-science/energy-materials/high-purity-salts) - [Oxides & Ceramics](https://www.sigmaaldrich.com/US/en/products/materials-science/energy-materials/oxides-and-ceramics) - [Quantum Dots](https://www.sigmaaldrich.com/US/en/products/materials-science/energy-materials/quantum-dots) - [Solar Energy Materials](https://www.sigmaaldrich.com/US/en/products/materials-science/energy-materials/solar-energy-materials) - [Solution & Vapor Deposition Precursors](https://www.sigmaaldrich.com/US/en/products/materials-science/energy-materials/solution-and-vapor-deposition-precursors) - [Molecular Biology & Functional Genomics](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics) - [Cloning & Expression](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/cloning-and-expression) - [Molecular Cloning & Protein Expression](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/cloning-and-expression/molecular-cloning-and-protein-expression) - [Transfection](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/cloning-and-expression/transfection) - [Epigenetics](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/epigenetics) - [Gene Editing & Functional Genomics](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/gene-editing-and-functional-genomics) - [CRISPR & Gene Editing](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/gene-editing-and-functional-genomics/crispr-gene-editing) - [Genetic Screening](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/gene-editing-and-functional-genomics/genetic-screening) - [RNAi Libraries](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/gene-editing-and-functional-genomics/rnai-libraries) - [RNAi Single Clones](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/gene-editing-and-functional-genomics/rnai-single-clones) - [<i>In situ</i> Hybridization Probes & Reagents](https://www.sigmaaldrich.com/US/en/products/clinical-diagnostics/tissue-diagnostics/zytovision-in-situ-hybridization-probes) - [Microbiome](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/microbiome) - [NGS Library Preparation](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/ngs-library-prep) - [Nucleic Acid Electrophoresis & Hybridization](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/nucleic-acid-electrophoresis-and-hybridization) - [Nucleic Acid Electrophoresis, Transfer & Quantitation](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/nucleic-acid-electrophoresis-and-hybridization/nucleic-acid-electrophoresis-transfer-and-quantitation) - [Nucleic Acid Labeling](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/nucleic-acid-electrophoresis-and-hybridization/nucleic-acid-labeling) - [Nucleic Acid Purification](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/nucleic-acid-purification) - [gDNA Purification](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/nucleic-acid-purification/gdna-purification) - [Plasmid DNA Purification](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/nucleic-acid-purification/plasmid-dna-purification) - [Reaction Clean-Up](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/nucleic-acid-purification/reaction-clean-up) - [RNA Purification](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/nucleic-acid-purification/rna-purification) - [Oligos, qPCR Probes & Peptides](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/oligos-and-qpcr-probes) - [Custom & Predesigned DNA Oligos and qPCR Probes](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/oligos-and-qpcr-probes/custom-predesigned-dna-oligos-and-qpcr-probes) - [Custom & Predesigned RNA Oligos, siRNA Duplexes and Controls](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/oligos-and-qpcr-probes/custom-predesigned-rna-oligos-sirna-duplexes-controls) - [Custom Peptides](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/oligos-and-qpcr-probes/custom-peptides) - [PCR & Amplification](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/pcr-and-amplification) - [Kapa Biosystems PCR Reagents](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/pcr-and-amplification/kapa-biosystems-pcr-reagents) - [PCR Reagent & Kits](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/pcr-and-amplification/pcr-reagents-and-kits) - [PCR Supplies & Equipment](https://www.sigmaaldrich.com/US/en/products/labware/pcr-supplies-and-equipment) - [Whole Genome Amplification](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/pcr-and-amplification/whole-genome-amplification) - [Roche<sup>®</sup> Life Science Products](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/roche-life-science-products) - [mAbs Development & Manufacturing](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies) - [Antibody Drug Discovery](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies/antibody-drug-discovery) - [Lead Selection & Optimization](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies/antibody-drug-discovery/lead-discovery) - [Preclinical Development](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies/antibody-drug-discovery/preclinical-development) - [Target Discovery](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies/antibody-drug-discovery/target-discovery) - [Characterization & Quality Control](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies/characterization-and-quality-control) - [Aggregate Analysis](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies/characterization-and-quality-control/aggregate-analysis) - [Intact Mass Analysis](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies/characterization-and-quality-control/intact-mass-analysis) - [Peptide Mapping](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies/characterization-and-quality-control/peptide-mapping) - [Post-Translational Modification](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies/characterization-and-quality-control/post-translational-modification-analysis) - [Titer Determination](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies/characterization-and-quality-control/titer-determination) - [Process Development, Manufacturing, Formulation & Final Fill](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies/process-development-manufacturing) - [Downstream Processing (DSP)](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies/process-development-manufacturing/downstream-processing-mabs) - [Formulation & Final Fill](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies/process-development-manufacturing/formulation-final-fill-mabs) - [Upstream Processing (USP)](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies/process-development-manufacturing/upstream-processing-mabs) - [mRNA Development & Manufacturing](https://www.sigmaaldrich.com/US/en/integrated-offerings/mrna-development-manufacturing) - [mRNA Analytical & Quality Control](https://www.sigmaaldrich.com/US/en/integrated-offerings/mrna-development-manufacturing/mrna-analytical-quality-control) - [mRNA Development](https://www.sigmaaldrich.com/US/en/integrated-offerings/mrna-development-manufacturing/mrna-development) - [mRNA Manufacturing & Formulation](https://www.sigmaaldrich.com/US/en/integrated-offerings/mrna-development-manufacturing/mrna-manufacturing-formulation) - [mRNA Research](https://www.sigmaaldrich.com/US/en/integrated-offerings/mrna-development-manufacturing/mrna-research) - [Pharma & Biopharma Manufacturing](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing) - [Active Pharmaceutical Ingredients](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/active-pharmaceutical-ingredients) - [API Processing Chemicals](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/active-pharmaceutical-ingredients/api-processing-chemicals) - [Folates](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/active-pharmaceutical-ingredients/folates) - [Portfolio APIs](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/active-pharmaceutical-ingredients/portfolio-apis) - [Bioprocessing & Formulation Raw Materials](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/bioprocessing-formulation-raw-materials) - [Bioprocessing Liquid Cell Culture Media & Buffers](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/bioprocessing-formulation-raw-materials/liquid-cell-culture-media-buffers) - [Buffers & pH Adjusters](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/buffer-media-prep/buffers-and-ph-adjusters) - [Cleaning in Place](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/bioprocessing-formulation-raw-materials/cleaning-in-place) - [Detergents for Biopharma Applications](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/bioprocessing-formulation-raw-materials/detergents) - [Downstream Process & Formulation Chemicals](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/bioprocessing-formulation-raw-materials/downstream-process-formulation-chemicals) - [Endonuclease](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/bioprocessing-formulation-raw-materials/endonuclease) - [High-Quality Chemicals for mRNA Manufacturing](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/bioprocessing-formulation-raw-materials/high-quality-chemicals-for-mrna-manufacturing) - [Upstream Process Chemicals](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/bioprocessing-formulation-raw-materials/upstream-process-chemicals) - [Bioprocessing Cell Culture](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/bioprocessing-cell-culture) - [Bioprocessing Cell Culture Media](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/bioprocessing-cell-culture/bioprocessing-cell-culture-media) - [Bioprocessing Cell Lines](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/bioprocessing-cell-culture/bioprocessing-cell-lines) - [Bioprocessing Liquid Cell Culture Media & Buffers](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/bioprocessing-formulation-raw-materials/liquid-cell-culture-media-buffers) - [Bioprocessing Recombinant Supplements](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/bioprocessing-cell-culture/recombinant-supplements) - [Bulk Powder Transfer Bags](https://www.sigmaaldrich.com/US/en/services/custom-products/bulk-powder-transfer-bags) - [Cell Retention](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/bioprocessing-cell-culture/cell-retention) - [Custom GMP Cell Culture Media](https://www.sigmaaldrich.com/US/en/services/custom-products/custom-gmp-cell-culture-products) - [Media Filtration](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/buffer-media-prep/media-filtration) - [Viral Vector Upstream Platforms](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/bioprocessing-cell-culture/viral-vector-upstream-platforms) - [Bioprocessing Systems](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/bioprocessing-systems) - [Chromatography Columns for Bioprocessing](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/chromatography-bioprocessing/chromatography-columns) - [Chromatography Systems](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/chromatography-bioprocessing/chromatography-systems) - [Clarification Filter Holders & Systems](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/clarification-harvest/clarification-filter-holders-and-systems-for-bioprocessing) - [Integrity Testers](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/sterile-filtration-and-bioburden-control/integrity-testers) - [Single-Use Mixers](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/buffer-media-prep/single-use-mixers) - [Stainless Steel Connectors, Valves & Mixers](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/fluid-management/stainless-steel-connectors-valves-mixers) - [Tangential Flow Filtration Holders & Systems](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/ultrafiltration-diafiltration/tangential-flow-holders-systems) - [Virus Filter Holders & Systems](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/viral-clearance/virus-filter-holders-and-systems) - [Buffer & Media Prep](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/buffer-media-prep) - [Buffers & pH Adjusters](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/buffer-media-prep/buffers-and-ph-adjusters) - [Buffer Filtration](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/buffer-media-prep/buffer-filtration) - [Media Filtration](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/buffer-media-prep/media-filtration) - [Single-Use Mixers](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/buffer-media-prep/single-use-mixers) - [Chromatography](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/chromatography-bioprocessing) - [Affinity Chromatography Resins](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/chromatography-bioprocessing/affinity-resins) - [Chromatography Columns for Bioprocessing](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/chromatography-bioprocessing/chromatography-columns) - [Chromatography Systems](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/chromatography-bioprocessing/chromatography-systems) - [Ion Exchange Chromatography Resins](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/chromatography-bioprocessing/ion-exchange-chromatography) - [Membrane Chromatography](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/chromatography-bioprocessing/membrane-chromatography) - [Reverse Phase/Normal Phase Chromatography Resins](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/chromatography-bioprocessing/reverse-normal-phase-chromatography) - [Size Exclusion Chromatography Resins](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/chromatography-bioprocessing/size-exclusion-chromatography) - [Clarification & Harvest](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/clarification-harvest) - [Clarification Depth Filters & Pretreatment Solutions](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/clarification-harvest/clarification-depth-filters-pretreatment-solutions) - [Clarification Filter Holders & Systems](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/clarification-harvest/clarification-filter-holders-and-systems-for-bioprocessing) - [Clarification Prefilters](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/clarification-harvest/clarification-prefilters) - [Fluid Management](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/fluid-management) - [Connection/Disconnection for Bioprocessing](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/fluid-management/connection-disconnection-for-bioprocessing) - [Fluid Transport & Storage](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/fluid-management/fluid-transport-and-storage) - [Single-Use Assemblies](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/fluid-management/single-use-assemblies) - [Single-Use Mixers](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/buffer-media-prep/single-use-mixers) - [Stainless Steel Connectors, Valves & Mixers](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/fluid-management/stainless-steel-connectors-valves-mixers) - [Formulation](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/formulation) - [Activated & Functionalized PEGs](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/formulation/activated-functionalized-pegs) - [Biomolecule Formulation](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/formulation/biomolecule-formulation) - [Granulated Materials](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/formulation/granulated-materials) - [Injectables & Parenteral Formulations](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/formulation/injectables-parenteral-formulations) - [Liquid Formulation](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/formulation/liquid-formulation) - [Protein Stabilizers](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/formulation/protein-stabilizers) - [Semisolid Formulation](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/formulation/semisolid-formulation) - [Solid Formulation](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/formulation/solid-formulation) - [Synthetic Lipids](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/formulation/synthetic-lipids) - [Viscosity Reduction Platform](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/formulation/viscosity-reduction-platform) - [Sterile & Aseptic Sampling Solutions](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/sterile-and-aseptic-sampling) - [Sterile Process Sampling](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/sterile-and-aseptic-sampling/manual-sterile-sampling) - [Sampling with MAST<sup>®</sup> Autosampling Solution](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/sterile-and-aseptic-sampling/automated-aseptic-sampling) - [Sterile Filtration & Bioburden Control](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/sterile-filtration-and-bioburden-control) - [Buffer Filtration](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/buffer-media-prep/buffer-filtration) - [Filter Housings](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/sterile-filtration-and-bioburden-control/filter-housings) - [Final Sterile Filtration & Filling](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/sterile-filtration-and-bioburden-control/final-sterile-filtration-and-filling) - [Gas & Vent Filters](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/sterile-filtration-and-bioburden-control/gas-and-vent-filters) - [Integrity Testers](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/sterile-filtration-and-bioburden-control/integrity-testers) - [Media Filtration](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/buffer-media-prep/media-filtration) - [Prefilters & Bioburden Control](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/sterile-filtration-and-bioburden-control/prefilters-and-bioburden-control) - [Sterile Filters](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/sterile-filtration-and-bioburden-control/sterile-filters) - [Ultrafiltration & Diafiltration](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/ultrafiltration-diafiltration) - [Tangential Flow Filtration Devices](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/ultrafiltration-diafiltration/filtration-devices) - [Tangential Flow Filtration Holders & Systems](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/ultrafiltration-diafiltration/tangential-flow-holders-systems) - [Viral Clearance](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/viral-clearance) - [Integrity Testers](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/sterile-filtration-and-bioburden-control/integrity-testers) - [Virus Filter Holders & Systems](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/viral-clearance/virus-filter-holders-and-systems) - [Virus Filters](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/viral-clearance/virus-filters) - [Virus Inactivation](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/viral-clearance/virus-inactivation) - [Protein Biology](https://www.sigmaaldrich.com/US/en/products/protein-biology) - [Antibodies](https://www.sigmaaldrich.com/US/en/products/protein-biology/antibodies) - [Enhanced Validation Antibodies](https://www.sigmaaldrich.com/US/en/products/protein-biology/antibodies/enhanced-validation-ab) - [Flow Cytometry Antibodies](https://www.sigmaaldrich.com/US/en/products/protein-biology/antibodies/flow-cytometry-antibodies) - [Prestige Antibodies<sup>®</sup>](https://www.sigmaaldrich.com/US/en/products/protein-biology/antibodies/prestige-antibodies) - [Primary Antibodies](https://www.sigmaaldrich.com/US/en/products/protein-biology/antibodies/primary-antibodies) - [Secondary Antibodies](https://www.sigmaaldrich.com/US/en/products/protein-biology/antibodies/secondary-antibodies) - [Small Pack Antibodies](https://www.sigmaaldrich.com/US/en/products/protein-biology/antibodies/small-pack-antibodies) - [ZooMAb<sup>®</sup> Recombinant Antibodies](https://www.sigmaaldrich.com/US/en/products/protein-biology/antibodies/zoomab-antibodies) - [Bioactive Small Molecules](https://www.sigmaaldrich.com/US/en/products/protein-biology/bioactive-small-molecules) - [Structural Genomics Consortium](https://www.sigmaaldrich.com/US/en/products/protein-biology/bioactive-small-molecules/structural-genomics-consortium) - [Duolink<sup>®</sup> PLA - Protein Interaction Technology](https://www.sigmaaldrich.com/US/en/products/protein-biology/duolink-proximity-ligation-assay) - [Immunoassay Platform Solutions](https://www.sigmaaldrich.com/US/en/products/protein-biology/immunoassay-platform-solutions) - [ELISA Kits](https://www.sigmaaldrich.com/US/en/products/protein-biology/immunoassay-platform-solutions/elisa-kits) - [MILLIPLEX<sup>®</sup> Kits](https://www.sigmaaldrich.com/US/en/products/protein-biology/immunoassay-platform-solutions/milliplex-multiplex-assays-for-luminex-technology) - [SMC<sup>™</sup> Technology](https://www.sigmaaldrich.com/US/en/products/protein-biology/immunoassay-platform-solutions/single-molecule-counting-technology) - [Protein Electrophoresis & Western Blotting](https://www.sigmaaldrich.com/US/en/products/protein-biology/protein-electrophoresis-and-western-blotting) - [Electrophoresis & Transfer Equipment](https://www.sigmaaldrich.com/US/en/products/protein-biology/protein-electrophoresis-and-western-blotting/electrophoresis-and-transfer-equipment) - [Transfer Membranes & Kits](https://www.sigmaaldrich.com/US/en/products/protein-biology/protein-electrophoresis-and-western-blotting/transfer-membranes-and-kits) - [Immunodetection Reagents & Substrates](https://www.sigmaaldrich.com/US/en/products/protein-biology/protein-electrophoresis-and-western-blotting/immunodetection-reagents-and-substrates) - [Membrane Immunodetection Devices](https://www.sigmaaldrich.com/US/en/products/protein-biology/protein-electrophoresis-and-western-blotting/membrane-immunodetection-devices) - [Protein Electrophoresis Gels & Buffers](https://www.sigmaaldrich.com/US/en/products/protein-biology/protein-electrophoresis-and-western-blotting/protein-electrophoresis-gels-and-buffers) - [Protein Electrophoresis Gel Stains](https://www.sigmaaldrich.com/US/en/products/protein-biology/protein-electrophoresis-and-western-blotting/protein-electrophoresis-gel-stains) - [Protein Markers](https://www.sigmaaldrich.com/US/en/products/protein-biology/protein-electrophoresis-and-western-blotting/protein-markers) - [Transfer Buffers & Reagents](https://www.sigmaaldrich.com/US/en/products/protein-biology/protein-electrophoresis-and-western-blotting/transfer-buffers-and-reagents) - [Proteins & Enzymes](https://www.sigmaaldrich.com/US/en/products/protein-biology/proteins-and-enzymes) - [Albumins & Transport Proteins](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/cell-culture-supplements-and-reagents/albumins-and-transport-proteins) - [Coenzymes](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/biochemicals/coenzymes) - [Detection Substrates & Enzymes](https://www.sigmaaldrich.com/US/en/products/protein-biology/proteins-and-enzymes/detection-substrates-and-enzymes) - [Drug Analysis Enzymes](https://www.sigmaaldrich.com/US/en/products/protein-biology/proteins-and-enzymes/drug-analysis-enzymes) - [Glycobiology Profiling Tools](https://www.sigmaaldrich.com/US/en/products/protein-biology/proteins-and-enzymes/glycosidases) - [Nucleases](https://www.sigmaaldrich.com/US/en/products/protein-biology/proteins-and-enzymes/nucleases) - [Proteases](https://www.sigmaaldrich.com/US/en/products/protein-biology/proteins-and-enzymes/proteases) - [Tissue Dissociation](https://www.sigmaaldrich.com/US/en/products/protein-biology/proteins-and-enzymes/tissue-dissociation) - [Protein Mass Spectrometry](https://www.sigmaaldrich.com/US/en/products/protein-biology/protein-mass-spectrometry) - [Protein Purification Chromatography](https://www.sigmaaldrich.com/US/en/products/protein-biology/protein-purification-chromatography) - [Antibody Protein Purification](https://www.sigmaaldrich.com/US/en/products/protein-biology/protein-sample-prep/antibody-protein-purification) - [Biotinylated Protein Purification](https://www.sigmaaldrich.com/US/en/products/protein-biology/protein-sample-prep/biotinylated-protein-purification) - [FLAG<sup>®</sup> Purification](https://www.sigmaaldrich.com/US/en/products/protein-biology/protein-sample-prep/flag-purification) - [Recombinant/Fusion Tag Protein Purification](https://www.sigmaaldrich.com/US/en/products/protein-biology/protein-sample-prep/recombinant-fusion-tag-protein-purification) - [Protein Sample Prep](https://www.sigmaaldrich.com/US/en/products/protein-biology/protein-sample-prep) - [Amicon<sup>®</sup> Centrifugals](https://www.sigmaaldrich.com/US/en/products/protein-biology/protein-sample-prep/amicon-centrifugals) - [Antibody Protein Purification](https://www.sigmaaldrich.com/US/en/products/protein-biology/protein-sample-prep/antibody-protein-purification) - [Biotinylated Protein Purification](https://www.sigmaaldrich.com/US/en/products/protein-biology/protein-sample-prep/biotinylated-protein-purification) - [FLAG<sup>®</sup> Purification](https://www.sigmaaldrich.com/US/en/products/protein-biology/protein-sample-prep/flag-purification) - [Inhibitor Cocktails](https://www.sigmaaldrich.com/US/en/products/protein-biology/protein-sample-prep/inhibitor-cocktails) - [Laboratory Concentration Devices](https://www.sigmaaldrich.com/US/en/products/protein-biology/protein-sample-prep/laboratory-concentration-devices) - [Laboratory Dialysis & Diafiltration Devices](https://www.sigmaaldrich.com/US/en/products/protein-biology/protein-sample-prep/laboratory-dialysis-and-diafiltration-devices) - [Recombinant/Fusion Tag Protein Purification](https://www.sigmaaldrich.com/US/en/products/protein-biology/protein-sample-prep/recombinant-fusion-tag-protein-purification) - [Subcellular Fractionation Reagents](https://www.sigmaaldrich.com/US/en/products/protein-biology/protein-sample-prep/subcellular-fractionation-reagents) - [Whole Cell Lysis Reagents & Enhancers](https://www.sigmaaldrich.com/US/en/products/protein-biology/protein-sample-prep/whole-cell-lysis-reagents-and-enhancers) - [Water Purification](https://www.sigmaaldrich.com/US/en/products/water-purification) - [Milli-Q<sup>®</sup> Benchtop Water Purification Systems](https://www.sigmaaldrich.com/US/en/products/water-purification/milli-q-benchtop-water-purification-systems) - [Milli-Q<sup>®</sup> High-Flow Water Purification Systems](https://www.sigmaaldrich.com/US/en/products/water-purification/milli-q-high-flow-water-purification-systems) - [Milli-Q<sup>®</sup> Clinical Water Purification Systems](https://www.sigmaaldrich.com/US/en/products/water-purification/milli-q-clinical-water-purification-systems) - [Milli-Q<sup>®</sup> Consumables](https://www.sigmaaldrich.com/US/en/products/water-purification/milli-q-consumables) - [Milli-Q<sup>®</sup> Accessories](https://www.sigmaaldrich.com/US/en/products/water-purification/milli-q-accessories) - Applications - [Analytical Chemistry](https://www.sigmaaldrich.com/US/en/applications/analytical-chemistry) - [Atomic Spectroscopy](https://www.sigmaaldrich.com/US/en/applications/analytical-chemistry/atomic-spectroscopy) - [Calibration, Qualification, Validation](https://www.sigmaaldrich.com/US/en/applications/analytical-chemistry/calibration-qualification-and-validation) - [Gas Chromatography (GC)](https://www.sigmaaldrich.com/US/en/applications/analytical-chemistry/gas-chromatography) - [Liquid Chromatography](https://www.sigmaaldrich.com/US/en/applications/analytical-chemistry/liquid-chromatography) - [Large Molecule HPLC](https://www.sigmaaldrich.com/US/en/applications/analytical-chemistry/liquid-chromatography/large-molecule-hplc) - [Low Pressure Liquid Chromatography](https://www.sigmaaldrich.com/US/en/applications/analytical-chemistry/liquid-chromatography/low-pressure-liquid-chromatography) - [Small Molecule HPLC](https://www.sigmaaldrich.com/US/en/applications/analytical-chemistry/liquid-chromatography/small-molecule-hplc) - [Mass Spectrometry (MS)](https://www.sigmaaldrich.com/US/en/applications/analytical-chemistry/mass-spectrometry) - [Nuclear Magnetic Resonance (NMR)](https://www.sigmaaldrich.com/US/en/applications/analytical-chemistry/nuclear-magnetic-resonance) - [Photometry & Reflectometry](https://www.sigmaaldrich.com/US/en/applications/analytical-chemistry/photometry-and-reflectometry) - [Sample Preparation](https://www.sigmaaldrich.com/US/en/applications/analytical-chemistry/sample-preparation) - [Sample Filtration](https://www.sigmaaldrich.com/US/en/applications/analytical-chemistry/sample-preparation/filtration) - [Sample Purification](https://www.sigmaaldrich.com/US/en/applications/analytical-chemistry/sample-preparation/purification) - [QuEChERS Sample Preparation](https://www.sigmaaldrich.com/US/en/applications/analytical-chemistry/sample-preparation/quechers) - [Solid Phase Extraction](https://www.sigmaaldrich.com/US/en/applications/analytical-chemistry/sample-preparation/solid-phase-extraction) - [Solid Phase Microextraction](https://www.sigmaaldrich.com/US/en/applications/analytical-chemistry/sample-preparation/solid-phase-microextraction) - [Thin Layer Chromatography (TLC)](https://www.sigmaaldrich.com/US/en/applications/analytical-chemistry/thin-layer-chromatography) - [Titration & Karl Fischer](https://www.sigmaaldrich.com/US/en/applications/analytical-chemistry/titration-and-karl-fischer) - [Water for Analytical Chemistry](https://www.sigmaaldrich.com/US/en/applications/water-purification/water-analytical-chemistry) - [Wet Chemical Analysis](https://www.sigmaaldrich.com/US/en/applications/analytical-chemistry/wet-chemical-analysis) - [Cell Culture & Analysis](https://www.sigmaaldrich.com/US/en/applications/cell-culture-and-cell-culture-analysis) - [Cell Analysis](https://www.sigmaaldrich.com/US/en/applications/cell-culture-and-cell-culture-analysis/cell-analysis) - [Cell-based Assays](https://www.sigmaaldrich.com/US/en/applications/cell-culture-and-cell-culture-analysis/cell-analysis/cell-based-assays) - [Cell Counting & Health analysis](https://www.sigmaaldrich.com/US/en/applications/cell-culture-and-cell-culture-analysis/cell-analysis/cell-counting-and-health-analysis) - [Imaging Analysis & Live Cell Imaging](https://www.sigmaaldrich.com/US/en/applications/cell-culture-and-cell-culture-analysis/cell-analysis/imaging-analysis-and-live-cell-imaging) - [Cell Culture by Cell Type](https://www.sigmaaldrich.com/US/en/applications/cell-culture-and-cell-culture-analysis/cell-culture-by-cell-type) - [Mammalian Cell Culture](https://www.sigmaaldrich.com/US/en/applications/cell-culture-and-cell-culture-analysis/cell-culture-by-cell-type/mammalian-cell-culture) - [Microbial Cell Culture](https://www.sigmaaldrich.com/US/en/applications/cell-culture-and-cell-culture-analysis/cell-culture-by-cell-type/microbial-cell-culture) - [Plant Tissue Culture](https://www.sigmaaldrich.com/US/en/applications/cell-culture-and-cell-culture-analysis/cell-culture-by-cell-type/plant-tissue-culture) - [Primary Cell Culture](https://www.sigmaaldrich.com/US/en/applications/cell-culture-and-cell-culture-analysis/cell-culture-by-cell-type/primary-cell-culture) - [Stem Cell Culture](https://www.sigmaaldrich.com/US/en/applications/cell-culture-and-cell-culture-analysis/cell-culture-by-cell-type/stem-cell-culture) - [Cell Culture by Technique](https://www.sigmaaldrich.com/US/en/applications/cell-culture-and-cell-culture-analysis/cell-culture-by-technique) - [3D Cell Culture](https://www.sigmaaldrich.com/US/en/applications/cell-culture-and-cell-culture-analysis/cell-culture-by-technique/3d-cell-culture) - [Cell Culture Media Preparation](https://www.sigmaaldrich.com/US/en/applications/cell-culture-and-cell-culture-analysis/cell-culture-by-technique/cell-culture-media-preparation) - [Cell Growth & Maintenance](https://www.sigmaaldrich.com/US/en/applications/cell-culture-and-cell-culture-analysis/cell-culture-by-technique/cell-growth-and-maintenance) - [Transfection & Gene Editing](https://www.sigmaaldrich.com/US/en/applications/cell-culture-and-cell-culture-analysis/cell-culture-by-technique/transfection-and-gene-editing) - [Cell Culture for Manufacturing](https://www.sigmaaldrich.com/US/en/applications/cell-culture-and-cell-culture-analysis/cell-culture-for-manufacturing) - [Cell Culture Troubleshooting](https://www.sigmaaldrich.com/US/en/applications/cell-culture-and-cell-culture-analysis/cell-culture-troubleshooting) - [Chemistry & Synthesis](https://www.sigmaaldrich.com/US/en/applications/chemistry-and-synthesis) - [ADC & Bioconjugation](https://www.sigmaaldrich.com/US/en/applications/chemistry-and-synthesis/adc-and-bioconjugation) - [Lead Discovery](https://www.sigmaaldrich.com/US/en/applications/chemistry-and-synthesis/lead-discovery) - [Peptide Synthesis](https://www.sigmaaldrich.com/US/en/applications/chemistry-and-synthesis/peptide-synthesis) - [Protein Degradation](https://www.sigmaaldrich.com/US/en/applications/chemistry-and-synthesis/protein-degradation) - [Reaction Design & Optimization](https://www.sigmaaldrich.com/US/en/applications/chemistry-and-synthesis/reaction-design-and-optimization) - [Synthetic Methods](https://www.sigmaaldrich.com/US/en/applications/chemistry-and-synthesis/synthetic-methods) - [C-H Functionalization](https://www.sigmaaldrich.com/US/en/applications/chemistry-and-synthesis/synthetic-methods/ch-functionalization) - [Cross Coupling](https://www.sigmaaldrich.com/US/en/applications/chemistry-and-synthesis/synthetic-methods/cross-coupling) - [Fluorination](https://www.sigmaaldrich.com/US/en/applications/chemistry-and-synthesis/synthetic-methods/fluorination) - [Metathesis](https://www.sigmaaldrich.com/US/en/applications/chemistry-and-synthesis/synthetic-methods/metathesis) - [Organic Reaction Toolbox](https://www.sigmaaldrich.com/US/en/applications/chemistry-and-synthesis/synthetic-methods/organic-reaction-toolbox) - [Photocatalysis](https://www.sigmaaldrich.com/US/en/applications/chemistry-and-synthesis/synthetic-methods/photocatalysis) - [Clinical & Diagnostics](https://www.sigmaaldrich.com/US/en/applications/clinical-testing-and-diagnostics-manufacturing) - [Bacteriology](https://www.sigmaaldrich.com/US/en/applications/clinical-testing-and-diagnostics-manufacturing/bacteriology) - [Blood Typing](https://www.sigmaaldrich.com/US/en/applications/clinical-testing-and-diagnostics-manufacturing/blood-typing) - [Clinical & Forensics Testing](https://www.sigmaaldrich.com/US/en/applications/clinical-testing-and-diagnostics-manufacturing/clinical-and-forensic-testing) - [Cytology & Cytodiagnosis](https://www.sigmaaldrich.com/US/en/applications/clinical-testing-and-diagnostics-manufacturing/cytology-and-microscopy) - [Diagnostic Immunohistochemistry](https://www.sigmaaldrich.com/US/en/applications/clinical-testing-and-diagnostics-manufacturing/diagnostic-immunohistochemistry) - [Hematology](https://www.sigmaaldrich.com/US/en/applications/clinical-testing-and-diagnostics-manufacturing/hematology) - [Histology/Histopathology](https://www.sigmaaldrich.com/US/en/applications/clinical-testing-and-diagnostics-manufacturing/histology) - [IVD Manufacturing](https://www.sigmaaldrich.com/US/en/applications/clinical-testing-and-diagnostics-manufacturing/ivd-manufacturing) - [Water for Clinical Diagnostics](https://www.sigmaaldrich.com/US/en/applications/water-purification/water-clinical-diagnostics) - [Environmental & Cannabis Testing](https://www.sigmaaldrich.com/US/en/applications/environmental-testing-and-industrial-hygiene) - [Air Sampling & Monitoring](https://www.sigmaaldrich.com/US/en/applications/environmental-testing-and-industrial-hygiene/air-testing) - [Cannabis Testing](https://www.sigmaaldrich.com/US/en/applications/environmental-testing-and-industrial-hygiene/cannabis-testing) - [Cannabinoids & Potency](https://www.sigmaaldrich.com/US/en/applications/environmental-testing-and-industrial-hygiene/cannabis-testing/cannabinoid-profiling-potency-testing) - [Pesticides & Mycotoxins](https://www.sigmaaldrich.com/US/en/applications/environmental-testing-and-industrial-hygiene/cannabis-testing/pesticides-mycotoxins-in-cannabis) - [Terpenes](https://www.sigmaaldrich.com/US/en/applications/environmental-testing-and-industrial-hygiene/cannabis-testing/terpenes-cannabis) - [Drinking Water Testing​](https://www.sigmaaldrich.com/US/en/applications/environmental-testing-and-industrial-hygiene/drinking-water-testing) - [Soil, Solid Waste, & Groundwater Testing](https://www.sigmaaldrich.com/US/en/applications/environmental-testing-and-industrial-hygiene/soil-solid-waste-groundwater-testing) - [Waste Water & Process Water Testing](https://www.sigmaaldrich.com/US/en/applications/environmental-testing-and-industrial-hygiene/waste-water-and-process-water-testing) - [Food & Beverage Testing & Manufacturing](https://www.sigmaaldrich.com/US/en/applications/food-and-beverage-testing-and-manufacturing) - [Chemical Analysis](https://www.sigmaaldrich.com/US/en/applications/food-and-beverage-testing-and-manufacturing/chemical-analysis-for-food-and-beverage) - [Flavor & Fragrance Formulation](https://www.sigmaaldrich.com/US/en/applications/food-and-beverage-testing-and-manufacturing/flavor-and-fragrance-formulation) - [Microbiological Analysis](https://www.sigmaaldrich.com/US/en/applications/food-and-beverage-testing-and-manufacturing/microbiological-analysis-for-food-and-beverage) - [Regulatory Compliance​](https://www.sigmaaldrich.com/US/en/applications/food-and-beverage-testing-and-manufacturing/regulatory-compliance-for-food-and-beverage) - [Genomics](https://www.sigmaaldrich.com/US/en/applications/genomics) - [Advanced Gene Editing](https://www.sigmaaldrich.com/US/en/applications/genomics/advanced-gene-editing) - [Cloning & Expression](https://www.sigmaaldrich.com/US/en/applications/genomics/cloning-and-expression) - [DNA & RNA Purification](https://www.sigmaaldrich.com/US/en/applications/genomics/dna-and-rna-purification) - [Epigenetics](https://www.sigmaaldrich.com/US/en/applications/genomics/epigenetics) - [Functional Genomics Screening](https://www.sigmaaldrich.com/US/en/applications/genomics/functional-genomics-screening) - [Gene Expression & Silencing](https://www.sigmaaldrich.com/US/en/applications/genomics/gene-expression-and-silencing) - [Next Gen Sequencing](https://www.sigmaaldrich.com/US/en/applications/genomics/next-gen-sequencing) - [Nucleic Acid Gel Electrophoresis](https://www.sigmaaldrich.com/US/en/applications/genomics/nucleic-acid-gel-electrophoresis) - [Nucleic Acid Labeling & Detection](https://www.sigmaaldrich.com/US/en/applications/genomics/nucleic-acid-labeling-and-detection) - [PCR](https://www.sigmaaldrich.com/US/en/applications/genomics/pcr) - [qPCR](https://www.sigmaaldrich.com/US/en/applications/genomics/qpcr) - [Sequencing](https://www.sigmaaldrich.com/US/en/applications/genomics/sequencing) - [Materials Science & Engineering](https://www.sigmaaldrich.com/US/en/applications/materials-science-and-engineering) - [3D Bioprinting](https://www.sigmaaldrich.com/US/en/applications/materials-science-and-engineering/3d-bioprinting) - [3D Printing](https://www.sigmaaldrich.com/US/en/applications/materials-science-and-engineering/3d-printing) - [Batteries, Supercapacitors, Fuel Cells](https://www.sigmaaldrich.com/US/en/applications/materials-science-and-engineering/batteries-supercapacitors-and-fuel-cells) - [Bioelectronics](https://www.sigmaaldrich.com/US/en/applications/materials-science-and-engineering/bioelectronics) - [Biosensors & Bioimaging](https://www.sigmaaldrich.com/US/en/applications/materials-science-and-engineering/biosensors-and-bioimaging) - [Chemical Vapor Deposition](https://www.sigmaaldrich.com/US/en/applications/materials-science-and-engineering/chemical-vapor-deposition) - [Contact Lens & Dental Manufacturing](https://www.sigmaaldrich.com/US/en/applications/materials-science-and-engineering/contact-lens-and-dental-manufacturing) - [Drug Delivery](https://www.sigmaaldrich.com/US/en/applications/materials-science-and-engineering/drug-delivery) - [Electron Microscopy](https://www.sigmaaldrich.com/US/en/applications/materials-science-and-engineering/electron-microscopy) - [Microelectronics & Nanoelectronics](https://www.sigmaaldrich.com/US/en/applications/materials-science-and-engineering/microelectronics-and-nanoelectronics) - [Nanoparticle & Microparticle Synthesis](https://www.sigmaaldrich.com/US/en/applications/materials-science-and-engineering/nanoparticle-and-microparticle-synthesis) - [Organic Electronics](https://www.sigmaaldrich.com/US/en/applications/materials-science-and-engineering/organic-electronics) - [Photovoltaics & Solar Cells](https://www.sigmaaldrich.com/US/en/applications/materials-science-and-engineering/photovoltaics-and-solar-cells) - [Polymer Synthesis](https://www.sigmaaldrich.com/US/en/applications/materials-science-and-engineering/polymer-synthesis) - [Solid State Synthesis](https://www.sigmaaldrich.com/US/en/applications/materials-science-and-engineering/solid-state-synthesis) - [Tissue Engineering](https://www.sigmaaldrich.com/US/en/applications/materials-science-and-engineering/tissue-engineering) - [Microbiological Testing](https://www.sigmaaldrich.com/US/en/applications/microbiological-testing) - [Bioburden Testing](https://www.sigmaaldrich.com/US/en/applications/microbiological-testing/bioburden-testing) - [Culture Media Preparation](https://www.sigmaaldrich.com/US/en/applications/microbiological-testing/microbial-culture-media-preparation) - [Media Fill (APS)](https://www.sigmaaldrich.com/US/en/applications/microbiological-testing/media-fills) - [Microbial Water Testing](https://www.sigmaaldrich.com/US/en/applications/microbiological-testing/microbial-water-testing) - [Mycoplasma Testing](https://www.sigmaaldrich.com/US/en/applications/microbiological-testing/mycoplasma-testing) - [Pathogen & Spoilage Testing](https://www.sigmaaldrich.com/US/en/applications/microbiological-testing/pathogen-and-spoilage-testing) - [Pyrogen Testing](https://www.sigmaaldrich.com/US/en/applications/microbiological-testing/pyrogen-testing) - [Sterility Testing](https://www.sigmaaldrich.com/US/en/applications/microbiological-testing/sterility-testing) - [Surface & Personnel Testing](https://www.sigmaaldrich.com/US/en/applications/microbiological-testing/surface-and-personnel-testing) - [Viable Air Monitoring](https://www.sigmaaldrich.com/US/en/applications/microbiological-testing/viable-air-monitoring) - [mAbs Development & Manufacturing](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies) - [Antibody Drug Discovery](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies/antibody-drug-discovery) - [Lead Selection & Optimization](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies/antibody-drug-discovery/lead-discovery) - [Preclinical Development](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies/antibody-drug-discovery/preclinical-development) - [Target Discovery](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies/antibody-drug-discovery/target-discovery) - [Characterization & Quality Control](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies/characterization-and-quality-control) - [Aggregate Analysis](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies/characterization-and-quality-control/aggregate-analysis) - [Intact Mass Analysis](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies/characterization-and-quality-control/intact-mass-analysis) - [Peptide Mapping](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies/characterization-and-quality-control/peptide-mapping) - [Post-Translational Modification](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies/characterization-and-quality-control/post-translational-modification-analysis) - [Titer Determination](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies/characterization-and-quality-control/titer-determination) - [Process Development, Manufacturing, Formulation & Final Fill](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies/process-development-manufacturing) - [Downstream Processing (DSP)](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies/process-development-manufacturing/downstream-processing-mabs) - [Formulation & Final Fill](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies/process-development-manufacturing/formulation-final-fill-mabs) - [Upstream Processing (USP)](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies/process-development-manufacturing/upstream-processing-mabs) - [mRNA Development & Manufacturing](https://www.sigmaaldrich.com/US/en/integrated-offerings/mrna-development-manufacturing) - [mRNA Analytical & Quality Control](https://www.sigmaaldrich.com/US/en/integrated-offerings/mrna-development-manufacturing/mrna-analytical-quality-control) - [mRNA Development](https://www.sigmaaldrich.com/US/en/integrated-offerings/mrna-development-manufacturing/mrna-development) - [mRNA Manufacturing & Formulation](https://www.sigmaaldrich.com/US/en/integrated-offerings/mrna-development-manufacturing/mrna-manufacturing-formulation) - [mRNA Research](https://www.sigmaaldrich.com/US/en/integrated-offerings/mrna-development-manufacturing/mrna-research) - [Pharma & Biopharma Manufacturing](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing) - [Antibody Drug Conjugate Manufacturing](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/adc-manufacturing) - [Conjugation](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/adc-manufacturing/conjugation) - [Purification](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/adc-manufacturing/antibody-drug-conjugate-manufacturing-purification) - [Biopharma 4.0](https://www.sigmaaldrich.com/US/en/integrated-offerings/biopharma-4-0) - [Bioprocessing Automation & Control Software](https://www.sigmaaldrich.com/US/en/integrated-offerings/biopharma-4-0/bioprocessing-automation-control-software) - [Bioprocessing Data Analytics Software](https://www.sigmaaldrich.com/US/en/integrated-offerings/biopharma-4-0/bioprocessing-data-analytics-software) - [Closed Processing for Biomanufacturing](https://www.sigmaaldrich.com/US/en/integrated-offerings/biopharma-4-0/closed-processing-for-biomanufacturing) - [Intensified & Continuous Upstream (USP) Processing](https://www.sigmaaldrich.com/US/en/integrated-offerings/biopharma-4-0/intensified-upstream-processing) - [Intensified & Continuous Downstream (DSP) Processing](https://www.sigmaaldrich.com/US/en/integrated-offerings/biopharma-4-0/intensified-continuous-downstream-processing) - [Process Analytical Technology (PAT)](https://www.sigmaaldrich.com/US/en/integrated-offerings/biopharma-4-0/process-analytical-technology) - [Biotech Resource Hub](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/biotech-resource-hub) - [Discovery](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/biotech-resource-hub/discovery) - [Pre-clinical](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/biotech-resource-hub/pre-clinical) - [Phase I-II](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/biotech-resource-hub/phase-i-ii) - [Phase III and Manufacturing](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/biotech-resource-hub/phase-iii-and-manufacturing) - [Regulatory](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/biotech-resource-hub/regulatory) - [Startup Programs](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/biotech-resource-hub/startup-programs) - [Blood Plasma Fractionation](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/plasma-manufacturing) - [Cell Therapy Manufacturing](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/cell-therapy-manufacturing) - [Classical Pharma Manufacturing](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/classical-pharma-manufacturing) - [Final Fill Strategies](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/classical-pharma-manufacturing/final-fill-strategies) - [Liquid Formulation Strategies](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/classical-pharma-manufacturing/liquid-formulation-strategies) - [Solid Formulation Strategies](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/classical-pharma-manufacturing/solid-formulation-strategies) - [Sterile Filtration Strategies](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/classical-pharma-manufacturing/sterile-filtration-strategies) - [Gene Therapy Manufacturing](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/gene-therapy-manufacturing) - [Viral Vector Upstream Processing](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/gene-therapy-manufacturing/viral-vector-upstream-processing) - [Viral Vector Downstream Processing](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/gene-therapy-manufacturing/viral-vector-downstream-processing) - [Viral Vector Formulation & Final Fill](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/gene-therapy-manufacturing/viral-vector-formulation-and-final-fill) - [Viral Vector Characterization & Biosafety Testing](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/gene-therapy-manufacturing/viral-vector-characterization-and-biosafety-testing) - [Viral Vector Contract Development & Manufacturing](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/gene-therapy-manufacturing/viral-vector-contract-development-and-manufacturing) - [Pharma Analysis & QC](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/pharmaceutical-analysis-quality-control) - [Biologics & Biosimilars Characterization](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/pharmaceutical-analysis-quality-control/biologics-biosimilars-characterization) - [Compendial Testing & Regulatory Guidance](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/pharmaceutical-analysis-quality-control/compendial-testing-regulatory-guidance) - [Small Molecules Analysis & Quality Control (QC)](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/pharmaceutical-analysis-quality-control/small-molecules-analysis-quality-control) - [Sterile & Aseptic Sampling](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/sampling) - [Vaccine Manufacturing](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/vaccine-manufacturing) - [Cell-Based Vaccine Manufacturing](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/vaccine-manufacturing/cell-based-vaccine-manufacturing) - [mRNA Vaccine Manufacturing](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/vaccine-manufacturing/mrna-vaccines-process-manufacturing) - [pDNA Vaccine Manufacturing](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/vaccine-manufacturing/plasmid-dna-vaccines-manufacturing) - [Protein Subunit Vaccine Manufacturing](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/vaccine-manufacturing/protein-subunit-vaccine-manufacturing) - [Viral-like Particles Vaccine Manufacturing](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/vaccine-manufacturing/viral-like-particles-vaccine-manufacturing) - [Viral Vector Vaccine Manufacturing](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/vaccine-manufacturing/viral-vector-vaccine-manufacturing) - [Protein Biology](https://www.sigmaaldrich.com/US/en/applications/protein-biology) - [ELISA](https://www.sigmaaldrich.com/US/en/applications/protein-biology/elisa) - [Enzyme Activity Assays](https://www.sigmaaldrich.com/US/en/applications/protein-biology/enzyme-activity-assays) - [Flow Cytometry](https://www.sigmaaldrich.com/US/en/applications/protein-biology/flow-cytometry) - [Gel Electrophoresis](https://www.sigmaaldrich.com/US/en/applications/protein-biology/gel-electrophoresis) - [Immunohistochemistry](https://www.sigmaaldrich.com/US/en/applications/protein-biology/immunohistochemistry) - [Interrogation of Protein Pathways](https://www.sigmaaldrich.com/US/en/applications/protein-biology/interrogation-protein-pathways) - [Lysis & Protein Extraction](https://www.sigmaaldrich.com/US/en/applications/protein-biology/lysis-and-protein-extraction) - [Protein & Nucleic Acid Interactions](https://www.sigmaaldrich.com/US/en/applications/protein-biology/protein-and-nucleic-acid-interactions) - [Protein Concentration & Buffer Exchange](https://www.sigmaaldrich.com/US/en/applications/protein-biology/protein-concentration-and-buffer-exchange) - [Protein Expression](https://www.sigmaaldrich.com/US/en/applications/protein-biology/protein-expression) - [Protein Labeling & Modification](https://www.sigmaaldrich.com/US/en/applications/protein-biology/protein-labeling-and-modification) - [Protein Pulldown](https://www.sigmaaldrich.com/US/en/applications/protein-biology/protein-pulldown) - [Protein Purification](https://www.sigmaaldrich.com/US/en/applications/protein-biology/protein-purification) - [Protein Quantitation](https://www.sigmaaldrich.com/US/en/applications/protein-biology/protein-quantitation) - [Protein Structural Analysis](https://www.sigmaaldrich.com/US/en/applications/protein-biology/protein-structural-analysis) - [Western Blotting](https://www.sigmaaldrich.com/US/en/applications/protein-biology/western-blotting) - [Protein Mass Spectrometry](https://www.sigmaaldrich.com/US/en/applications/protein-biology/protein-mass-spectrometry) - [Research & Disease Areas](https://www.sigmaaldrich.com/US/en/applications/research-disease-areas) - [Cancer Research](https://www.sigmaaldrich.com/US/en/applications/research-disease-areas/cancer-research) - [Cell & Developmental Biology Research](https://www.sigmaaldrich.com/US/en/applications/research-disease-areas/cell-and-developmental-biology-research) - [Cell Signaling](https://www.sigmaaldrich.com/US/en/applications/research-disease-areas/cell-signaling) - [Glycobiology](https://www.sigmaaldrich.com/US/en/applications/research-disease-areas/glycobiology) - [Metabolomics Research](https://www.sigmaaldrich.com/US/en/applications/research-disease-areas/metabolomics-research) - [Neuroscience Research](https://www.sigmaaldrich.com/US/en/applications/research-disease-areas/neuroscience-research) - [Pharmacology & Drug Discovery Research](https://www.sigmaaldrich.com/US/en/applications/research-disease-areas/pharmacology-and-drug-discovery-research) - [Water Purification](https://www.sigmaaldrich.com/US/en/applications/water-purification) - [Water for Analytical Chemistry](https://www.sigmaaldrich.com/US/en/applications/water-purification/water-analytical-chemistry) - [Water for Cell & Molecular Biology](https://www.sigmaaldrich.com/US/en/applications/water-purification/water-cell-molecular-biology) - [Water for Clinical Diagnostics](https://www.sigmaaldrich.com/US/en/applications/water-purification/water-clinical-diagnostics) - [Understanding Lab Water](https://www.sigmaaldrich.com/US/en/applications/water-purification/understanding-lab-water) - Services - [Contract Manufacturing](https://www.sigmaaldrich.com/US/en/services/contract-manufacturing) - [ADC & Bioconjugation](https://www.sigmaaldrich.com/US/en/services/contract-manufacturing/adc-bioconjugation) - [Diagnostic OEM & CMO Services](https://www.sigmaaldrich.com/US/en/services/ivd-development-manufacturing/diagnostic-oem-cmo) - [mRNA & LNP](https://www.sigmaaldrich.com/US/en/services/contract-manufacturing/mrna-and-lnp-formulation-ctdmo-services) - [Lipids CDMO Services](https://www.sigmaaldrich.com/US/en/services/contract-manufacturing/mrna-and-lnp-formulation-ctdmo-services/lipids-cdmo-services) - [Lipid Nanoparticle CDMO Service](https://www.sigmaaldrich.com/US/en/services/contract-manufacturing/mrna-and-lnp-formulation-ctdmo-services/lipid-nanoparticle-cdmo-services) - [Small Molecule](https://www.sigmaaldrich.com/US/en/services/contract-manufacturing/small-molecule) - [Activated Polyethylene Glycol (PEGs)](https://www.sigmaaldrich.com/US/en/services/contract-manufacturing/peg) - [APIs](https://www.sigmaaldrich.com/US/en/services/contract-manufacturing/complex-apis) - [Highly Potent APIs](https://www.sigmaaldrich.com/US/en/services/contract-manufacturing/high-potent-apis) - [Viral Vector](https://www.sigmaaldrich.com/US/en/services/contract-manufacturing/viral-vector-manufacturing) - [AAV Production](https://www.sigmaaldrich.com/US/en/services/contract-manufacturing/viral-vector-manufacturing/aav-production) - [Gene Therapy Process Development](https://www.sigmaaldrich.com/US/en/services/contract-manufacturing/viral-vector-manufacturing/gene-therapy-process-development) - [Lentiviral Vectors](https://www.sigmaaldrich.com/US/en/services/contract-manufacturing/viral-vector-manufacturing/lentiviral-vectors) - [Contract Testing](https://www.sigmaaldrich.com/US/en/services/contract-testing) - [Analytical Development](https://www.sigmaaldrich.com/US/en/services/contract-testing/analytical-development-product-characterization) - [ADC Product Characterization](https://www.sigmaaldrich.com/US/en/services/contract-testing/analytical-development-product-characterization/adc-characterization) - [Analytical Development and Characterization for Adeno-Associated Virus (AAV)](https://www.sigmaaldrich.com/US/en/services/contract-testing/analytical-development-product-characterization/analytical-development-characterization-adeno-associated-virus) - [mAb Product Characterization](https://www.sigmaaldrich.com/US/en/services/contract-testing/analytical-development-product-characterization/mab-characterization) - [mRNA Analytical Development](https://www.sigmaaldrich.com/US/en/services/contract-testing/analytical-development-product-characterization/mrna-analytical-development) - [Bulk Harvest Release Testing](https://www.sigmaaldrich.com/US/en/services/contract-testing/bulk-harvest-release-testing) - [Cell & Gene Therapy Bulk Harvest Release Testing](https://www.sigmaaldrich.com/US/en/services/contract-testing/bulk-harvest-release-testing/cell-gene-therapy) - [mAbs Bulk Harvest Release Testing](https://www.sigmaaldrich.com/US/en/services/contract-testing/bulk-harvest-release-testing/mabs-bulk) - [Vaccine Harvest Release Testing](https://www.sigmaaldrich.com/US/en/services/contract-testing/bulk-harvest-release-testing/vaccine) - [Cell & Virus Bank Manufacturing & Testing](https://www.sigmaaldrich.com/US/en/services/contract-testing/cell-viral-bank-testing) - [Biorepository & Storage](https://www.sigmaaldrich.com/US/en/services/contract-testing/cell-viral-bank-testing/storage) - [Cell Bank Manufacturing](https://www.sigmaaldrich.com/US/en/services/contract-testing/cell-viral-bank-testing/cell-bank-manufacturing) - [Cell Line Characterization](https://www.sigmaaldrich.com/US/en/services/contract-testing/cell-viral-bank-testing/cell-line-characterization) - [Genetic Stability Testing](https://www.sigmaaldrich.com/US/en/services/contract-testing/cell-viral-bank-testing/genetic-stability-testing) - [Virus Bank Manufacturing](https://www.sigmaaldrich.com/US/en/services/contract-testing/cell-viral-bank-testing/virus-bank-manufacturing) - [Final Product Release Testing](https://www.sigmaaldrich.com/US/en/services/contract-testing/final-product-release-testing) - [Cell & Gene Therapy Final Product Release Testing](https://www.sigmaaldrich.com/US/en/services/contract-testing/final-product-release-testing/cell-gene-therapy) - [mAbs Final Product Release Testing](https://www.sigmaaldrich.com/US/en/services/contract-testing/final-product-release-testing/mabs-product-release-testing) - [Rapid Molecular Detection](https://www.sigmaaldrich.com/US/en/services/contract-testing/rapid-molecular-detection) - [Blazar™ Rapid Molecular Detection](https://www.sigmaaldrich.com/US/en/services/contract-testing/rapid-molecular-detection/blazar-rapid-molecular-detection) - [Next Generation Sequencing](https://www.sigmaaldrich.com/US/en/services/contract-testing/rapid-molecular-detection/next-generation-sequencing) - [Raw Material Testing](https://www.sigmaaldrich.com/US/en/services/contract-testing/raw-material-testing) - [Stability Testing Services](https://www.sigmaaldrich.com/US/en/services/contract-testing/stability-testing-services) - [Viral Clearance Testing](https://www.sigmaaldrich.com/US/en/services/contract-testing/viral-clearance-testing) - [Provise<sup>®</sup> Clearance Services](https://www.sigmaaldrich.com/US/en/services/contract-testing/viral-clearance-testing/complete-clearance) - [Standard & Hybrid Clearance Services](https://www.sigmaaldrich.com/US/en/services/contract-testing/viral-clearance-testing/standard-clearance) - [Custom Products](https://www.sigmaaldrich.com/US/en/services/custom-products) - [Bulk Powder Transfer Bags](https://www.sigmaaldrich.com/US/en/services/custom-products/bulk-powder-transfer-bags) - [CADI: Custom Assay Development & Innovation](https://www.sigmaaldrich.com/US/en/services/custom-products/custom-milliplex-multiplex-assays-and-elisas) - [Cell Culture Media Stability & Testing Services](https://www.sigmaaldrich.com/US/en/services/custom-products/cell-culture-media-stability-and-testing-services) - [Cell Design Studio™ Cell Engineering Services](https://www.sigmaaldrich.com/US/en/services/custom-products/custom-cell-lines) - [CHOZN<sup>®</sup> Cell Line Engineering and Development](https://www.sigmaaldrich.com/US/en/services/custom-products/chozn-cell-line-engineering-and-development) - [Contract ZooMAb<sup>®</sup> Antibody Development Services](https://www.sigmaaldrich.com/US/en/services/custom-products/contract-zoomab-antibody-development-services) - [Critical Raw Materials](https://www.sigmaaldrich.com/US/en/services/custom-products/critical-raw-materials) - [Custom Diagnostic Antibody Development & Manufacturing Services](https://www.sigmaaldrich.com/US/en/services/ivd-development-manufacturing/custom-diagnostic-antibody-development-and-manufacturing-services) - [Custom GC Columns](https://www.sigmaaldrich.com/US/en/services/custom-products/customized-gc-columns) - [Custom GMP Cell Culture Media](https://www.sigmaaldrich.com/US/en/services/custom-products/custom-gmp-cell-culture-products) - [Custom HPLC Columns](https://www.sigmaaldrich.com/US/en/services/custom-products/custom-hplc-column-request) - [Custom Media Development Services](https://www.sigmaaldrich.com/US/en/services/custom-products/custom-media-development-services) - [Custom Nucleic Acids](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/oligos-and-qpcr-probes) - [Custom SPE Tubes & 96-Well Plates](https://www.sigmaaldrich.com/US/en/services/custom-products/custom-spe-tubes-and-96-well-plates) - [Custom SPME Fibers](https://www.sigmaaldrich.com/US/en/services/custom-products/custom-spme-fibers) - [Custom Test Strips & Papers](https://www.sigmaaldrich.com/US/en/services/custom-products/custom-test-strips-and-papers) - [Diagnostic OEM & CMO Services](https://www.sigmaaldrich.com/US/en/services/ivd-development-manufacturing/diagnostic-oem-cmo) - [Eshmuno<sup>®</sup> Fit Custom Affinity Resin Development Services](https://www.sigmaaldrich.com/US/en/services/custom-products/eshmuno-fit-custom-affinity-resin-development-services) - [Production-Scale Materials & Custom Services](https://www.sigmaaldrich.com/US/en/services/custom-products/bulk-and-custom-services) - [Large-Volume Products Supply-Chain](https://www.sigmaaldrich.com/US/en/services/custom-products/bulk-and-custom-services/large-volume-products-supply-chain) - [Scalable Manufacturing & Custom Packaging](https://www.sigmaaldrich.com/US/en/services/custom-products/bulk-and-custom-services/scalable-manufacturing-and-custom-packaging) - [Reference Materials](https://www.sigmaaldrich.com/US/en/services/custom-products/reference-materials) - [Small Molecule Library Design (Aldrich Market Select)](https://www.sigmaaldrich.com/US/en/services/custom-products/small-molecule-library-design) - [Stable Isotope Custom & GMP Products](https://www.sigmaaldrich.com/US/en/services/custom-products/stable-isotope-custom-and-gmp-products) - [Digital Solutions for Life Science](https://www.sigmaaldrich.com/US/en/services/software-and-digital-platforms) - [AIDDISON™ AI-Powered Drug Discovery Software](https://www.sigmaaldrich.com/US/en/services/software-and-digital-platforms/aiddison-ai-powered-drug-discovery) - [Belysa<sup>®</sup> Immunoassay Curve Fitting Software](https://www.sigmaaldrich.com/US/en/services/software-and-digital-platforms/belysa-immunoassay-curve-fitting-software) - [Bioprocessing Automation and Control Software](https://www.sigmaaldrich.com/US/en/integrated-offerings/biopharma-4-0/bioprocessing-automation-control-software) - [Bioprocessing Data Analytics Software](https://www.sigmaaldrich.com/US/en/integrated-offerings/biopharma-4-0/bioprocessing-data-analytics-software) - [Catalexis Catalysts Screening Platform](https://www.sigmaaldrich.com/US/en/services/software-and-digital-platforms/catalexis-catalyst-screening-platform) - [Chemistwin<sup>®</sup> Digital Reference Materials](https://www.sigmaaldrich.com/US/en/services/software-and-digital-platforms/digital-reference-materials) - [DEL Extended Digital Service](https://www.sigmaaldrich.com/US/en/services/software-and-digital-platforms/dna-encoded-library-technology-drug-discovery) - [DOZN™ Tool](https://www.sigmaaldrich.com/US/en/services/software-and-digital-platforms/dozn-tool) - [mConfig™ Cell Culture Media and Chemicals Configurator](https://www.sigmaaldrich.com/US/en/services/software-and-digital-platforms/mconfig-cell-culture-media-chemicals-configurator) - [M-Trace<sup>®</sup> Electronic Test Record Software](https://www.sigmaaldrich.com/US/en/services/software-and-digital-platforms/m-trace-electronic-test-record-software) - [Millicell<sup>®</sup> Cloud Services](https://www.sigmaaldrich.com/US/en/services/software-and-digital-platforms/millicell-cloud-services) - [MQuant<sup>®</sup> StripScan](https://www.sigmaaldrich.com/US/en/services/software-and-digital-platforms/mquant-stripscan) - [MyMilli-Q<sup>™</sup> Digital Services](https://www.sigmaaldrich.com/US/en/services/software-and-digital-platforms/mymilli-q-digital-services) - [SYNTHIA<sup>™</sup> Retrosynthesis Software](https://www.sigmaaldrich.com/US/en/services/software-and-digital-platforms/synthia-retrosynthesis-software) - [Val@M™ Application for Validation Activites](https://www.sigmaaldrich.com/US/en/services/software-and-digital-platforms/valatm-validation-platform) - [IVD Development & Manufacturing](https://www.sigmaaldrich.com/US/en/services/ivd-development-manufacturing) - [Custom Diagnostic Antibody Development & Manufacturing Services](https://www.sigmaaldrich.com/US/en/services/ivd-development-manufacturing/custom-diagnostic-antibody-development-and-manufacturing-services) - [Diagnostic OEM & CMO Services](https://www.sigmaaldrich.com/US/en/services/ivd-development-manufacturing/diagnostic-oem-cmo) - [Lateral Flow Assay Development Services](https://www.sigmaaldrich.com/US/en/services/ivd-development-manufacturing/lateral-flow-services) - [Product Services](https://www.sigmaaldrich.com/US/en/services/product-services) - [Application Services for Solid Dose Formulations](https://www.sigmaaldrich.com/US/en/services/product-services/application-services-solid-dose-formulations) - [Calibration & Verification](https://www.sigmaaldrich.com/US/en/services/product-services/calibration-and-verification) - [Milli-Q<sup>®</sup> Calibration & Verification](https://www.sigmaaldrich.com/US/en/services/product-services/calibration-and-verification/calibration-verification-suitability-testing-of-milli-q-water-pu) - [Microbiology Testing Systems](https://www.sigmaaldrich.com/US/en/services/product-services/calibration-and-verification/calibration-verification-microbiology) - [Elevate Program](https://www.sigmaaldrich.com/US/en/services/product-services/elevate-quality-program) - [eMERGE™ Program](https://www.sigmaaldrich.com/US/en/services/product-services/the-emerge-standard-edata-exchange-platform) - [Emprove<sup>®</sup> Program](https://www.sigmaaldrich.com/US/en/services/product-services/emprove-program) - [Emprove<sup>®</sup> Cell Culture Media](https://www.sigmaaldrich.com/US/en/services/product-services/emprove-program/emprove-cell-culture-media) - [Emprove<sup>®</sup> Chemicals Portfolio](https://www.sigmaaldrich.com/US/en/services/product-services/emprove-program/emprove-chemicals-portfolio) - [Emprove<sup>®</sup> Chromatography Portfolio](https://www.sigmaaldrich.com/US/en/services/product-services/emprove-program/emprove-chromatography-portfolio) - [Emprove<sup>®</sup> Filter and Single-Use Component Portfolio](https://www.sigmaaldrich.com/US/en/services/product-services/emprove-program/emprove-filter-and-single-use-component-portfolio) - [Emprove<sup>®</sup> Suite](https://www.sigmaaldrich.com/US/en/services/product-services/emprove-program/emprove-suite) - [Maintenance & Service Plans](https://www.sigmaaldrich.com/US/en/services/product-services/maintenance-and-service-plans) - [Microbiology Testing Systems](https://www.sigmaaldrich.com/US/en/services/product-services/maintenance-and-service-plans/microbiology-maintenance-and-service-plans) - [Milli-Q<sup>®</sup> Maintenance & Service Plans](https://www.sigmaaldrich.com/US/en/services/product-services/maintenance-and-service-plans/milli-q-services-plans-and-maintenance-for-water-purification-sy) - [Spectroquant<sup>®</sup> Photometer Services](https://www.sigmaaldrich.com/US/en/services/product-services/maintenance-and-service-plans/spectroquant-photometer-services) - [System Service Reliance Plans](https://www.sigmaaldrich.com/US/en/services/product-services/maintenance-and-service-plans/system-service-reliance-plans) - [Milli-Q<sup>®</sup> Services & Support](https://www.sigmaaldrich.com/US/en/services/product-services/milli-q-services-and-support) - [Maintenance & Service Plans](https://www.sigmaaldrich.com/US/en/services/product-services/maintenance-and-service-plans/milli-q-services-plans-and-maintenance-for-water-purification-sy) - [Qualification & Validation](https://www.sigmaaldrich.com/US/en/services/product-services/systems-qualification/milliq-qualification-program) - [Calibration & Verification](https://www.sigmaaldrich.com/US/en/services/product-services/calibration-and-verification/calibration-verification-suitability-testing-of-milli-q-water-pu) - [Additional Services](https://www.sigmaaldrich.com/US/en/services/product-services/milli-q-services-and-support/milli-q-additional-services) - [MyMilli-Q™ Digital Services](https://www.sigmaaldrich.com/US/en/services/software-and-digital-platforms/mymilli-q-digital-services) - [mPredict™ Co-Crystal Prediction Service](https://www.sigmaaldrich.com/US/en/services/product-services/m-predict-co-crystal-prediction-service) - [Single-Use & Filter Validation Services](https://www.sigmaaldrich.com/US/en/services/product-services/single-use-filter-validation) - [Bacterial Retention​ Testing](https://www.sigmaaldrich.com/US/en/services/product-services/single-use-filter-validation/bacterial-retention) - [Chemical Compatibility​ Testing](https://www.sigmaaldrich.com/US/en/services/product-services/single-use-filter-validation/chemical-compatibility) - [Extractables & Leachables​](https://www.sigmaaldrich.com/US/en/services/product-services/single-use-filter-validation/extractables-and-leachables) - [Filter Integrity Testing​](https://www.sigmaaldrich.com/US/en/services/product-services/single-use-filter-validation/integrity-testing) - [Validation Service Levels](https://www.sigmaaldrich.com/US/en/services/product-services/single-use-filter-validation/validation-service-levels) - [Validation Services Consultancy​](https://www.sigmaaldrich.com/US/en/services/product-services/single-use-filter-validation/validation-services-consultancy) - [Systems & Equipment Installation](https://www.sigmaaldrich.com/US/en/services/product-services/systems-and-equipment-installation) - [Bioprocessing Systems Equipment Installation](https://www.sigmaaldrich.com/US/en/services/product-services/systems-and-equipment-installation/bioprocessing-systems-equipment) - [Bioprocessing System Training & Specialized Services](https://www.sigmaaldrich.com/US/en/services/product-services/systems-and-equipment-installation/bioprocessing-systems-training) - [Microbiology Testing Systems](https://www.sigmaaldrich.com/US/en/services/product-services/systems-and-equipment-installation/system-and-equipment-installation-microbiology-testing-systems) - [Systems Qualification](https://www.sigmaaldrich.com/US/en/services/product-services/systems-qualification) - [Bioprocessing Systems Qualification](https://www.sigmaaldrich.com/US/en/services/product-services/systems-qualification/bioprocessing-systems-qualification) - [Food & Beverages QC Systems Qualification](https://www.sigmaaldrich.com/US/en/services/product-services/systems-qualification/food-and-beverage-qc-systems-qualification) - [Milli-Q<sup>®</sup> Qualification & Validation](https://www.sigmaaldrich.com/US/en/services/product-services/systems-qualification/milliq-qualification-program) - [Pharma QC Systems Qualification](https://www.sigmaaldrich.com/US/en/services/product-services/systems-qualification/pharma-qc-systems-qualification) - [Validation Services](https://www.sigmaaldrich.com/US/en/services/product-services/validation-services) - [Food & Beverage Microbiology Method Validation](https://www.sigmaaldrich.com/US/en/services/product-services/validation-services/food-and-beverage-microbiology-method-validation) - [Pharma Microbiology Method Development & Validation](https://www.sigmaaldrich.com/US/en/services/product-services/validation-services/pharma-microbiology-method-development-validation) - [Val@M™ Application for Validation Activites](https://www.sigmaaldrich.com/US/en/services/software-and-digital-platforms/valatm-validation-platform) - [Support](https://www.sigmaaldrich.com/US/en/services/support) - [Inventory Management](https://www.sigmaaldrich.com/US/en/services/support/inventory-management) - [M Lab™ Collaboration Centers](https://www.sigmaaldrich.com/US/en/services/support/mlab-collaboration-centers) - [Programs](https://www.sigmaaldrich.com/US/en/life-science/partnership-programs) - [Recycling](https://www.sigmaaldrich.com/US/en/services/support/recycling) - [Biopharma Recycling Program](https://www.sigmaaldrich.com/US/en/services/support/recycling/biopharma-recycling-program) - [Greener Cooler](https://www.sigmaaldrich.com/US/en/services/support/recycling/greener-cooler) - [Polystyrene Cooler Recycling](https://www.sigmaaldrich.com/US/en/services/support/recycling/polystyrene-cooler-return-program) - [Training & Education](https://www.sigmaaldrich.com/US/en/services/support/training-and-education) - Resources - [Documents](https://www.sigmaaldrich.com/US/en/documents-search?tab=coa) - [Certificates of Analysis (COA)](https://www.sigmaaldrich.com/US/en/documents-search?tab=coa) - [Safety Data Sheets (SDS)](https://www.sigmaaldrich.com/US/en/documents-search?tab=sds) - [Certificates of Quality (COQ)](https://www.sigmaaldrich.com/US/en/documents-search?tab=coq) - [Certificates of Origin (COO)](https://www.sigmaaldrich.com/US/en/documents-search?tab=coo) - [Learning Center](https://www.sigmaaldrich.com/US/en/life-science/learning-center) - Support - [Customer Support](https://www.sigmaaldrich.com/US/en/support/customer-support) - [Contact Us](https://www.sigmaaldrich.com/US/en/collections/offices) - [Get Site Smart](https://www.sigmaaldrich.com/US/en/life-science/ecommerce/website-update-info) - [FAQ](https://maestro.my.site.com/knowledgeportal/s/) - [Quality & Regulatory](https://www.sigmaaldrich.com/US/en/life-science/quality-and-regulatory-management) - [Calculators & Apps](https://www.sigmaaldrich.com/US/en/support/calculators-and-apps) - [Webinars](https://www.sigmaaldrich.com/US/en/collections/webinars)