Milli-Q® Direct for Water Purification

An ultrapure water system directly from tap producing RiOs™ and Milli-Q® water

Overview: In a single device, both RO (Type 3) water and ultrapure (Type 1) water are produced directly from potable water.

Milli-Q® Direct for Water Purification


Milli-Q Direct® Features and Benefits at a glance

To obtain ultrapure water quality, tap water is purified to RiOs™ (Type 3) water: First, the Progard® cartridge provides a comprehensive pretreatment to extend the lifetime of the Reverse Osmosis (RO) membrane. Intelligent RO ensures the optimization of the water consumption, quality and a constant flow rate. Water is then irradiated by the optional bactericidal UV lamp. Depending on daily volume needs, different production flow rates are available (8 & 16 L/h).

The RO water is stored in a polyethylene tank designed to minimize risks of contamination during water storage. The vent filter provides effective protection against airborne contaminants. The ASM, Automatic Sanitization Module, prevents biofilm formation. Water can be either sourced through the tank front valve or sent by a distribution pump to feed instruments such as a glassware washing machine.

Water then passes through a long-life dual wavelength UV lamp, which ensures organic molecule degradation by photooxidation. Next, it is processed through the QPAK® purification cartridge to reach a resistivity of 18.2 MΩ•cm (25°C) and a TOC value below 5 ppb. Finally, it recirculates through a loop to the dispenser, where an Application-Pak removes specific contaminants critical for your experiments. A range of purification cartridges and Application-Paks is available for you to select according to your applications.

Selected for its exceptional performance, Jetpore® virgin ion-exchange resin is used in all Milli-Q® purification cartridges. Jetpore® is made only for Milli-Q® systems.Both Progard® and QPAK® cartridges incorporate RFID technology. This provides instant visibility on cartridge parameters and also ensures a safe & optimal performance of your system, giving you full traceability.

Convenience • Simple dispensing & easy maintenance

Using the Milli-Q® Direct dispenser,

  • Save time thanks to the volumetric function. It will automatically deliver the water volume that you requested.
  • Effortlessly prepare solutions with the detachable, easy-to-handle dispenser. Its design has been conceived to fit the height and shape of all laboratory glassware.

Its graphic screen displays water quality and system status information to ensure your system is properly operating, providing the best working conditions for your experiments. A Quick Reference Guide located in the door of the Milli-Q® Direct system provides additional support for retrieving information. Easily replaceable cartridges, a long-lasting UV lamp coupled with timely service alerts, allows your system to run smoothly all year long. Millitrack® e-Solutions provide enhanced data management control, remote access capabilities to the system dashboard, and long-term electronic archiving for your Milli-Q® Direct. In addition, a complete range of Services, including Validation support, is provided by certified Field Service Engineers using calibrated equipment and Qualification Workbooks.

Quality Certificates

For full confidence in your Milli-Q® Direct system, it is delivered with a Certificate of Calibration for the built-in temperature and resistivity meters, and a Certificate of Conformity ensuring that it has been built and tested fully assembled following internal Standard Operating Procedures. In addition all Milli-Q® consumables are delivered with their Certificate of Quality. The manufacturing site is ISO® 9001 v.2000 and ISO® 140001 certified.

Water Specifications / International Conformity

Milli-Q® Direct ultrapure water (Type 1) water specifications
Resistivity at 25 °C1 18.2 MΩ•cm
TOC2 ≤ 5 ppb
Particulates (size > 0.22 µm)3 < 1 particulate/mL
Bacteria3,4 < 0.01 CFU/mL
Pyrogens (endotoxins)4 < 0.001 EU/mL
RNases4 < 1 pg/mL
DNases4 < 5 pg/mL
Flow rate Up to 2 L/min

1resistivity can also be displayed non-temperature-compensated as required by USP
2in the appropriate test conditions
3with Millipak® final filter
4With Biopak® polisher
These values are typical and may vary depending on the nature and concentration of contaminants in the feed water.

Milli-Q® Direct RO water (Type 3)
Ionic rejection 97 to 98%
Organic rejection for MW > 200 Dalton > 99 %
Particulates rejection > 99%
Production flow Rate 8 L/h (Milli-Q® Direct 8)
16 L/h (Milli-Q® Direct 16)
Delivery flow rate From storage tank tap: up to 2.5 L/min
From optional pump: up to 15 L/min at 1 bar


Feed water
Feed Water Conductivity at 25°C < 2000 µS/cm
Feed Water TOC < 2000 ppb
Feed Water Pressure 1 - 6 bar
Feed Water Temperature 5 - 35°C
Feed Water Chlorine* < 3 ppm
Feed Water Fouling Index** < 12
Feed water pH 4 to 10 pH units
Feed Water Connection 1/2 in Gaz M

(*) Feed Water Chlorine < 1ppm with Progard® T3 and > 3ppm with Progard® T3 + Prepak 1
(**) Feed Water SDI < 5 with Progard® T3 and > 12 with Progard® T3 + Prepak 1

System Specifications
Dimensions (H x W x D) 713 x 413 x 484 mm (28.07 x 16.25 x 18.03 in)
Operating weight 27 - 28 kg (59.5 - 61.7 lb)
Electric power supply voltage 100 - 230 V +/- 10%
Electric power supply frequency 50 - 60 Hz
Main unit data connection Ethernet (RJ45)



The Milli-Q® Direct system is tested by an independent and accredited company for compliance with the CE directives related to safety and electromagnetic compatibility. The report can be consulted on demand. The Milli-Q® Direct system is built using components and practices recommended by UL and has been cUL marked. The registration can be verified on the UL web site.