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2-Chlorotrityl Resins Preloaded with N-α-Fmoc-Protected Amino Acids

Chemfiles Volume 3 Article 4

The mild cleavage conditions for highly acid-labile 2-chlorotrityl resin enables the preparation of fully protected peptide fragments for convergent synthesis and selective side-chain derivatization. Because the amino acids attached to the 2-chlorotrityl resin are N-terminal-free, these resins are ready for the coupling reaction without any deprotection pre-treatments. The polymer matrix for our preloaded 2-chlorotrityl resins is polystyrene cross-linked with 1% DVB.

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