4-(4-Formyl-3-methoxyphenoxy)ethyl (“FMP”) Resin

Chemfiles Volume 3 Article 4

Dialkoxybenzaldehyde resin can be used for the production of C-terminal peptide N-alkylcarboxamides and peptide esters similar to the trialkoxybenzaldehyde-type backbone amide linker (BAL).(1-2) Reductive amination of the resin introducing a primary amine or an amino acid alkyl ester provides a polymer-bound secondary amine that is readily acylated employing activation by HATU/diisopropylethylamine. Cleavage of the C-terminal modified peptide is accomplished with 95% trifluoroacetic acid.

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  1. Jensen, K. J. et al. J. Am. Chem. Soc. 1998, 120, 5441.
  2. Dörner, B.; White, P. Proc. 25th Eur. Pept. Symp. Bajusz, S.; Hudecz, F. Eds.), Akadémiai Kiadó, Budapest 1999, 90.

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