Acrylamide-PEG Co-polymer (“PEGA”) Resin

ChemFiles Volume 3 Article 4

PEGA resins are a hydrophilic acrylamide-PEG co-polymer providing a really extensive and more uniform swelling in a wide range of solvents (from H2O, MeOH, EtOH to THF, MeCN and toluene). The extreme swelling volume of this support in the standard peptide synthesis solvents DCM and DMF together with their good stability make them ideally suited for batch as well as for continuous-flow syntheses. Mercaptoacetyl derivatized PEGA resin has been successfully used for the preparation of C-terminal peptide thioester fragments employing Boc chemistry. [1] Peptide thioesters are excellent tools in chemoselective ligations. The high swelling volume of PEGA resins makes the functionalities located within the polymer bead accessible to large biomolecules This unique feature allows for on-resin enzymatic assays[2] and enzymatic derivatizations in glycopeptide synthesis.(3)

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  1. Camarero, J. A. et al. J. Pept. Res. 1998, 51, 303.
  2. Meldal, M. et al. J. Chem. Soc. Chem. Commun. 1994, 1849.
  3. Meldal, M. et al. J. Pept. Sci. 1997, 4, 83.

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