Cross Metathesis

By: William Sommer, Aldrich ChemFiles 2009, 9.6, 7.

Cross metathesis has become an invaluable method for the preparation of olefins.1 While cross metathesis is typically conducted under mild conditions and is tolerant of a variety of functionalities, the chemo- and stereoselectivity of the reaction were more difficult to predict.2 However, due to advances in catalyst design and reaction understanding, predictability has improved.

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  1. Connon, S. J. et al. Angew. Chem. Int. Ed. 2003, 42, 1900.
  2. Chatterjee, A. K. et al. J. Am. Chem. Soc. 2003, 125, 11360.



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