Facile and Rapid Chiral Resolution with ChiroSolv® Kits

chemfiles volume 8 Supplement 1

Sigma-Aldrich® is pleased to partner with ChiroSolve, Inc. to offer, through an exclusive distribution agreement, a series of ready-to-use kits for chiral resolution of racemates. These kits allow scientists to quickly screen resolving agents and solvents against a racemate to find the optimum combination, as well as to optimize reaction conditions in order to separate a racemic mixture into its constituent enantiomers. They can be used for racemic acids, bases, alcohols, amino acids, aldehydes, and ketones.

There are four Acid Series kits and four Base Series kits, available individually or as the complete acid or base set. Each individual kit is in a ready-to-use, 96-vial, high-throughput format that allows the entire analysis to be performed inside the kit without removing any vials. The kit is made of polypropylene material that can withstand extreme temperatures (–20 to 120 °C), allowing the entire kit to be placed in an oven or ice bath without damage.

Acid Series Kits and Base Series Kits

The kits can be supplied in two different formats, either as kits for solid racemates or kits for liquid racemates. The kits for liquid racemates provide calibrated quantities of a unique resolving agent and solvent combination in each vial. The racemate can then simply be added to start the screening process. The kits for solid racemates allow the researcher to dissolve the racemate into a volatile solvent and then dispense the resultant solution into each vial containing a resolving agent. The volatile solvent is evaporated and the prepared screening solvents are then dispensed from a separate plate into each vial.

Resolving agents are chosen with manufacturing use in mind; they are relatively inexpensive and recoverable in high yield after the resolution is complete. Using all four kits in an acid or base series, 384 resolving agent–solvent combinations can be explored for a single racemate. The high-throughput format allows scientists to identify within 24 hours the optimum resolution process which might otherwise take over 2 months.

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