Highly Acid-Labile Resins for the Synthesis of Protected Peptide Carboxamides

ChemFiles Volume 3 Article 4

This extremely acid-labile resin provides Fmoc-/tBu-protected peptide amides by treatment with low concentrations of TFA (~ 1%).(1-2) Reductive alkylation of this support followed by acylation gives access to secondary carboxamide products.(3)

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  1. Albericio, F.; Barany, G. Int. J. Pept. Protein Res. 1987, 30, 206.
  2. Albericio, F. et al. J. Org. Chem. 1990, 55, 3730.
  3. Songster, M. F. et al. Lett. Pept. Sci. 1995, 2, 265.

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