Jørgensen Organocatalyst for Asymmetric Catalysis

Chemfiles Volume 7 Article 5

Recently, the Jørgensen group communicated the use of the prolinol-based silyl ether 1 as an effective organocatalyst for the epoxidation of a, b-unsaturated aldehydes in ethanol and aqueous solutions.1 Hydrogen peroxide was used as the oxidant, and the reactions proceed in moderate to good yields with ee’s up to 96%.

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  1. Zhuang, W. et al. Org. Biomol. Chem. 2005, 3, 3883.

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