Natural Amino Acid Building Blocks for Peptide Synthesis

By: Matthias Junkers, ChemFiles 2008, 8.7, 22.

With a growing peptide drug market the fast, reliable and uncomplicated synthesis of peptides is of paramount importance.1 Today, the most common synthetic approaches to medium and even large peptides follow the Boc/Bzl or Fmoc/tBu solid phase peptide synthesis strategies.2 A convenient list of the most popular Boc- and Fmoc-protected amino acid building blocks for these two synthesis strategies can be found in this issue. The Boc-protected amino acids are also frequently used in solution phase peptide synthesis procedures.

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  1. Marx, V. C&E News 2005, 83, 17.
  2. Houben-Weyl, Methods of Organic Chemistry, “Synthesis of Peptides and Peptidomimetics”, Thieme 2001, add. and suppl.vol. to the 4th ed. Vol E 22 a.

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