New Aromatic Terminal Alkynes

Chemfiles Volume 3 Article 5

The terminal alkyne functionality has a wide range of applications including most recently the synthesis of spiropyran substituted 2,3-dicyanopyrazines1 and (±)-asteriscanolide,2 as well as conversion to enamines using resin-bound 2° amines.3 Sigma-Aldrich offers a number of aromatic alkynes that can further enhance the reactivity of the alkyne group resulting in many new reactions and products for organic synthesis and medicinal chemistry.

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  1. Lee, B. et al. Bull. Korean Chem. Soc. 2002, 23(8), 1.
  2. Drafft, M. E. et al. Synthesis 2000, 1020.
  3. Aznar, F. et al. Tetrahedron Lett. 2000, 41, 5683.

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