PAL (Peptide Amide Linker) Resin

ChemFiles Volume 3 Article 4

PAL resin is a very useful tool for the synthesis of peptide carboxamides according to recent literature.(1, 2) Similar cleavage conditions to Rink (RAM) amide resins are required to effect final release of the peptides (95% TFA). N-Alkylated PAL resin 549444 is highly recommended for the synthesis of N-alkylamide peptides.(3)

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  1. Albericio, F.; Barany, G. Int. J. Pept. Protein Res. 1987, 30, 206.
  2. Albericio, F. et al. J. Org. Chem. 1990, 55, 3730.
  3. Songster, M. F. et al. Lett. Pept. Sci. 1995, 2, 265.

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