Aldrich ChemFiles 2006, 6.6, 15.

Aldrich ChemFiles 2006, 6.6, 15.

Accelerate your small-molecule synthesis and drug discovery success with our innovative catalyst technologies. PEPPSI™-IPr is distinguished by higher efficiency and superior functional group tolerance, and meets or exceeds the performance of traditional phosphine systems in industrially useful Suzuki, Negishi, and Buchwald-Hartwig reactions. This Pd(II) precatalyst, based upon an elegantly designed “throw-away” ligand concept, is rapidly activated under the reaction conditions to a Pd(0)-NHC complex, effectively promoting Sonagashira and Kumada couplings as well as α-arylation reactions. The catalyst’s efficient mediation of C–C and C–N bond-forming processes, robust stability, and kilogram availability make it attractive for widespread application in the global research and fine chemical arena.

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