Chemfiles Volume 7 Article 5

The use of electron-rich, sterically congested monodentate phosphine ligands, in conjunction with a metal precursor, has become a common paradigm in transition-metal-catalyzed coupling reactions. Developed by the Hartwig group, pentaphenyl(di-tert-butylphosphino)ferrocene (Q-Phos, Figure 1) has emerged to be a premier ligand in coupling reactions because of its remarkably broad utility in a variety of C–N, C–O, and C–C bond-forming reactions. Additionally, the pure ligand is exceedingly robust, being stable in open air and in solution.

Figure 1.

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