Rasta Resins

Chemfiles Volume 5 Article 11

Rasta Resins are produced by a unique living free radical polymerization process (Structure 1).1 The unique polymer structure of the Rasta Resin consists of a polystyrene core with long, linear polymer chains that contain the desired reagent, catalyst, or scavenger (Structure 2). Rasta Resins have higher loading than typical polymer-bound reagents. This increased loading is advantageous in that less polymer material is required to achieve the same synthetic results.2 Isocyanate on Rasta Resin can be utilized to scavenge excess primary and secondary amines from crude reactions.1 Chloromethyl on Rasta Resin can be used in the same manner as Merrifield resin to produce a wide range of organic compounds.3,4

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  1. Hodges, J.; L. Harikrishnan, L.; Ault-Justus, S. J. Comb. Chem. 2000, 2, 80.
  2. Linsley, C.; Hodges, J.; Filzen, G.; Watson, B.; Geyer, A. J. Comb. Chem. 2000, 2, 550.
  3. McAlpine, S.; Linsley, C.; Hodges, J.; Leonard, D.; Filzen, G. J. Comb. Chem. 2001, 3, 1.
  4. Wisnoski, D.; Leister, W.; Strauss, K.; Zhao, Z.; Lindsley, C. Tetrahedron Lett. 2003, 44, 4321

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