Rovis Triazolium Catalyst

ChemFiles 2006, 6.4, 14.

Rovis has demonstrated that triazolium salt (667080) in the presence of a base can act as an N-heterocyclic carbene organocatalyst in highly enantioselective intramolecular Stetter reactions. The Stetter reaction (a conjugate addition of an aldehyde to an α,β-unsaturated compound) is a superb method for construction of 1,4-dicarbonyl compounds bearing quaternary stereocenters (Scheme 16).1

Scheme 16.

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  1. Kerr, M. S.; Rovis, T. J. Am. Chem. Soc. 2004, 126, 8876.

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