Suzuki Coupling of Alkyl Chlorides

By: Josephine Nakhla, Aldrich ChemFiles 2009, 9.2, 12.

Aldrich ChemFiles 2009, 9.2, 12.

Gonzalez-Bobes and Fu reported the use of NiCl2•glyme in the presence of prolinol in the previously unprecedented Suzuki reactions of unactivated secondary alkyl chlorides. Both primary, secondary, cyclic and acyclic alkyl chlorides can be utilized in this transformation, as well as electron-rich and electron-poor arylboronic acids (Table 5).1

Table 5.

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  1. Gonzalez-Bobes, F.; Fu, G. C. J. Am. Chem. Soc. 2006, 128, 5360.

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