Synthesis of Heterocyclic Compounds Using Thiopseudourea Hydrochloride, Polymer-Bound

Chemfiles Volume 5 Article 11

Heterocyclic compounds are common scaffolds in drug discovery.1 Many different types of heterocyclic compounds can be prepared using new synthetic methods that have been developed based on supported reagents.2 Thiopseudourea hydrochloride, polymer-bound is a polymer reagent useful for synthesis of different types of 6-membered heterocycles, for example pyrimidines3 and 1,2,4-triazin-5-ones.1,3,4

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  1. Chauhan, P. M. S.; Kumar, A. Comb. Chem. High Throughput Screen. 2002, 5, 93.
  2. Franzen, R. G. J. Comb. Chem. 2000, 2, 195.
  3. Masquelint, T.; Sprenger, D.; Baer, R.; Gerber, F.; Mercadal, Y. Helv. Chim. Acta 1998, 81, 646.
  4. Yang, R.-Y.; Kaplan, A. Tetrahedron Lett. 2001, 42, 4433.

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