TentaGel® and HypoGel® 4-Alkoxybenzyl Alcohol Resins

Chemfiles Volume 3 Article 4

TentaGel® PHB and HypoGel® PHB resins (PHB = p-hydroxybenzyl alcohol) are excellent acid-labile supports for Fmoc-/tBuSPPS of peptide acids. Detachment of the peptide can be achieved with 95% TFA. Due to the unique properties of the TentaGel® PHB resin, synthesis can be performed both in a batch or in a continuous-flow system. Attachment of the C-terminal amino acid can be accomplished following standard procedures. For detailed information on cleavage conditions and attachment of C-terminal amino acid residues, please look at the references cited for Wang resins.

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