Unnatural Amino Acids

By: Matthias Junkers, Aldrich ChemFiles 2007, 7.2, 12.

Aldrich ChemFiles 2007, 7.2, 12.

Unnatural amino acids are utilized as chiral building blocks, conformational constraints, molecular scaffolds, or pharmacologically active compounds. They represent a nearly infinite array of diverse structural elements for the development of new therapeutic drugs. Small-molecule combinatorial libraries containing unnatural amino acid residues already show remarkable impact on drug discovery processes. Novel short-chain peptide ligand mimetics with both enhanced biological activity and improved proteolytic resistance are drug candidates in today’s R&D pipelines of pharmaceutical companies. Sigma-Aldrich is pleased to introduce 40 new additions to its unique and broad portfolio of more than 700 unnatural amino acids.

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