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Professor Abigail Doyle Professor Alessio Ciulli

The Ciulli group are broadly interested with understanding and exploiting the ligandability of protein-protein interactions (PPIs) and protein surfaces within complex biological systems using chemical and structural cell biology approaches. Current research efforts are directed towards targeting PPIs molecular recognition within protein families of biological and medical relevance within the Ubiquitin and Chromatin systems by developing small molecules that disrupt PPIs and that induce targeted protein degradation (PROTACs) - as tools to probe biology and leads for drug discovery.

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Standley EA1, Jamison TF.
J Am Chem Soc. 2013 Jan 30;135(4):1585-92. doi: 10.1021/ja3116718. Epub 2013 Jan 14.
The synthesis and characterization of the air-stable nickel(II) complex trans-(PCy(2)Ph)(2)Ni(o-tolyl)Cl is described in conjunction with an investigation of its use for the Mizoroki-Heck-type, room temperature, internally selective coupling of substituted benzyl chlorides with terminal alkenes...Read More
Testa A, Lucas X, Castro GV, Chan KH, Wright JE, Runcie AC, Gadd MS, Harrison WTA, Ko EJ, Fletcher D, Ciulli A.
J Am Chem Soc. 2018 Jul 25;140(29):9299-9313. doi: 10.1021/jacs.8b05807. Epub 2018 Jul 12.
Hydroxylation and fluorination of proline alters the pyrrolidine ring pucker and the trans:cis amide bond ratio in a stereochemistry-dependent fashion, affecting molecular recognition of proline-containing molecules by biological system...Read More
Maniaci C1, Hughes SJ, Testa A, Chen W, Lamont DJ, Rocha S, Alessi DR, Romeo R, Ciulli A.
Nat Commun. 2017 Oct 10;8(1):830. doi: 10.1038/s41467-017-00954-1.
E3 ubiquitin ligases are key enzymes within the ubiquitin proteasome system which catalyze the ubiquitination of proteins, targeting them for proteasomal degradation...Read More