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Professor Abigail Doyle Professor Don Coltart

Synthetic organic chemistry is the unifying feature of all research in the Coltart group. We have a particular interest in the development of new synthetic methods and the use of those methods to enable the total synthesis of structurally complex, biologically active natural products. Our methodology research focuses mainly on asymmetric carbon–carbon bond formation – with an emphasis on the α-alkylation of carbonyl compounds – as well as the synthesis of saturated and partially saturated heterocyclic compounds.

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Huynh U, McDonald SL, Lim D, Uddin MN, Wengryniuk SE, Dey S, Coltart DM.
J Org Chem. 2018 Nov 2;83(21):12951-12964. doi: 10.1021/acs.joc.8b00655. Epub 2018 Oct 3.
The α-alkylation of ketones is a fundamental synthetic transformation. The development of asymmetric variants of this reaction is important given that numerous natural products, drugs, and related compounds exist as α-functionalized ketones or derivatives thereof...Read More
Wengryniuk SE, Lim D, Coltart DM.
J Am Chem Soc. 2011 Jun 8;133(22):8714-20. doi: 10.1021/ja202267k. Epub 2011 May 12.
The first general method for the asymmetric α,α-bisalkylation of ketones having both α- and α'-protons is described. Both excellent regio- and stereoselectivity result...Read More
Lim D, Coltart DM.
Angew Chem Int Ed Engl. 2008;47(28):5207-10. doi: 10.1002/anie.200800848.
Distinguishing left from right: In the title reactions, chiral N‐amino cyclic carbamates (ACCs) substantially diminish the drawbacks associated with the use of chiral dialkyl hydrazines, yet provide excellent stereoselectivity and high yields...Read More