Gang Li Group – Professor Product Portal

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Professor Phil S Baran Professor Gang Li

Research in Prof. Gang Li's lab includes transition-metal-catalyzed C–H bond activation reactions and small molecule activation. In C–H bond activation, the research is focused on site-selective C–H bond functionalizations of biologically important molecules using novel auxiliaries and catalysts, including auxiliaries for meta- and para-selective C–H activation of arenes. In small molecule activation, activation of carbon dioxide (CO2) is studied with C–H bond activation to produce important carboxylic acid derivatives. The ultimate goal of the Li group is to develop catalytic reactions for building up molecular complexity in a rapid and atom-economical fashion.

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Li S1, Cai L1, Ji H1, Yang L1, Li G1,2.
Nat Commun. 2016 Jan 27;7:10443. doi: 10.1038/ncomms10443.
Benzoic acids are highly important structural motifs in drug molecules and natural products. Selective C-H bond functionalization of benzoic acids will provide synthetically useful tools for step-economical organic synthesis. Although direct ortho-C-H functionalizations of benzoic acids or their derivatives have been intensely sRead More
Yang L1, Li S1, Cai L1, Ding Y1, Fu L1, Cai Z1, Ji H1, Li G1.
Org Lett. 2017 May 19;19(10):2746-2749. doi: 10.1021/acs.orglett.7b01103. Epub 2017 May 8.
The trifluoroethyl aryl ethers are important motifs in drug molecules. However, a report devoted specifically to the study of transition-metal-catalyzed C-H trifluoroethoxylation has not been reported to date. A protocol of Pd(II)-catalyzed o-C-H trifluoroethoxylation of a broad range of benzoic acid derivatives (i.e., N-sulfonyRead More
Shangda Li, Huafang Ji, Lei Cai and Gang Li
DOI: 10.1039/C5SC01737H (Edge Article) Chem. Sci., 2015, 6, 5595-5600.
Site selectivity control is of vital importance in the direct functionalization of inert C–H bonds. Reported here is a novel example of remote regiodivergent ortho- and meta-C–H bond functionalizations of phenylethylamine derivatives by using a novel 2-cyanobenzoyl group as the original directing functionality, where the regioselectivity was adjusted by a methylation.Read More
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