Molander Group – Professor Product Portal

Professor Product Portal Index

Professor Gary Molander

The central theme of the Molander group's research is the development of new synthetic methods and their application to the synthesis of organic molecules. The group's current focus is to expand and improve the cross coupling reaction of organoboron compounds. Robust, air- and water-stable potassium organotrifluoroborates (R-BF3K), are employed to carry out couplings under relatively mild conditions using non-toxic components.

Molander Group website

Products available at Aldrich from the Molander Laboratory

John C Tellis, David N Primer, Gary A Molander
Science 2014-07-25
The routine application of C(sp3)-hybridized nucleophiles in cross-coupling reactions remains an unsolved challenge in organic chemistry. The sluggish transmetalation rates observed for the preferred organoboron reagents in such transformations are a consequence of the two-electron mechanism underlying the standard catalytic approach...Read More
Gary A Molander, Livia N Cavalcanti, Carolina García-García
Journal of Organic Chemistry 2013-07-05
Arylboronic acids are gaining increased importance as reagents and target structures in a variety of useful applications. Recently, the palladium-catalyzed synthesis of arylboronic acids employing the atom-economical tetrahydroxydiboron (BBA) reagent has been reported...Read More
Marc Presset, Daniel Oehlrich, Frederik Rombouts, Gary A Molander
Journal of Organic Chemistry 2013-12-20
Copper-mediated trifluoromethylation of unsaturated organotrifluoroborates with the Langlois reagent (NaSO2CF3) and TBHP allows the introduction of trifluoromethyl groups into a variety of organic substructures. The reactions are easy to set up, the conditions are mild and general, and the process provides access to trifluoromethylated alkynes, alkenes, arenes, and heteroarenes in fair to good yields...Read More
Gary A Molander, Sarah L J Trice, Steven M Kennedy, Spencer D Dreher, Matthew T Tudge
Journal of the American Chemical Society 2012-07-18
The Suzuki-Miyaura reaction has become one of the more useful tools for synthetic organic chemists. Until recently, there did not exist a direct way to make the most important component in the coupling reaction, namely the boronic acid. Current methods to make boronic acids often employ harsh or wasteful reagents to prepare boro...Read More
Gary A Molander, Sarah L J Trice, Steven M Kennedy
Journal of Organic Chemistry 2012-10-05
The use of bis-boronic acid for the direct synthesis of boronic acids has greatly facilitated the two-step, one-pot borylation/Suzuki cross-coupling reaction between aryl and heteroaryl halides. With use of Buchwald's second-generation XPhos preformed catalyst, high yields of cross-coupled products were obtained for most substra...Read More