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Professor Scott Grayson

The Grayson research labs have focused on the synthesis and characterization of well-defined polymers. One particular theme of research has involved the optimization of the mass spectral analysis of polymers using MALDI-TOF MS and associated calibration methodologies. These techniques can enable the elucidation of polymer end groups, the structural determination of byproducts, and the confirmation of polymerization mechanisms. This effort has included the development of robust, monodisperse dendrimers for use as a high molecular weight MS calibration standards.

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Department of Chemistry, Tulane University, New Orleans, LA, 70118, USA, sgrayson@tulane.edu.
J Am Soc Mass Spectrom. 2014 Mar;25(3):303-9.
The utilization of dendrimer calibrants as an alternative to peptides and proteins for high mass calibration is explored. These synthetic macromolecules exhibited a number of attractive advantages, including exceptional shelf-lives, broad compatibility with a wide range of matrices and solvents, and evenly spaced calibration masRead More
Tulane University, Department of Chemistry, Anal Chim Acta. 2014 Mar 13;816:28-40. doi:
End groups play a critical role in macromolecular coupling reactions for building complex polymer architectures, yet their identity and purity can be difficult to ascertain using traditional analytical technique. Recent advances in mass spectrometry techniques have made matrix-assisted laser desorption/ionization time-of-fight (Read More
Tulane University, Department of Chemistry, 2015 Percival Stern Hall, 6400 Freret Street, New Orleans, LA 70118, USA.Tulane University, Department of Chemistry, 2015 Percival Stern Hall, 6400 Freret Street, New Orleans, LA 70118, USA. Electronic address: sgrayson@tulane.edu.
Anal Chim Acta. 2014 Jan 15;808:175-89. doi
The synthesis of branched poly(ethylene glycol) (PEG) derivatives, namely star PEG and dendronized PEG, can be challenging and their purity can be difficult to ascertain using traditional techniques, such as NMR and GPC. Herein, the detailed characterization of these branched PEGs using MALDI-ToF MS was investigated in order to Read More

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