Gwilherm Evano Group – Professor Product Portal

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Professor Phil S Baran Professor Gwilherm Evano

Research in the Evano group focuses on three areas: natural product synthesis, copper catalysis, and the chemistry of hetero-substituted alkynes. In particular, they developed a set of efficient and robust procedures, mostly based on copper catalysis, for the synthesis of ynamides starting from readily available starting materials. They have also explored the synthetic potential of these bench-stable reagents which were shown to be remarkable substrates and building blocks, notably in anionic and cationic chemistry. By exploiting and rationalizing the singular and remarkable reactivity of ynamides, reaction pathways that could not be accessed with regular alkynes could be exploited to access various nitrogen-containing molecules, including complex and otherwise hardly accessible nitrogen heterocycles, with high levels of efficiency. The Evano group is currently continuing its work on the chemistry of ynamides, with an emphasis in asymmetric synthesis, and its extension to other classes of hetero-substituted acetylenes.

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Gwilherm Evano, Alexis Coste, Kévin Jouvin
Angewandte Chemie. International edition in English 2010-04-06
Ynamides display an exceptionally fine balance between stability and reactivity. They also offer unique and multiple opportunities for the inclusion of nitrogen-based functionalities into organic molecules, and are emerging as especially useful and versatile building blocks for organic synthesis. Recent breakthroughs in the prep...Read More
Wafa Gati, Mohamed M Rammah, Mohamed B Rammah, François Couty, Gwilherm Evano
Journal of the American Chemical Society 2012-06-06
An efficient and general method for the synthesis of 1,4-dihydropyridines and pyridines based on a lithiation/isomerization/intramolecular carbolithiation sequence is reported. This procedure provides an efficient, divergent, and straightforward entry to a wide range of polysubstituted dihydropyridines and pyridines starting fro...Read More
Cédric Theunissen, Benoît Métayer, Nicolas Henry, Guillaume Compain, Jérome Marrot, Agnès Martin-Mingot, Sébastien Thibaudeau, Gwilherm Evano
Journal of the American Chemical Society 2014-09-10
A novel and efficient keteniminium-initiated cationic polycyclization is reported. This reaction, which only requires triflic acid or bistriflimide as promoters, affords a straightforward entry to polycyclic nitrogen heterocycles possessing up to three contiguous stereocenters and seven fused cycles. These complex, polycyclic mo...Read More