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Professor Abigail Doyle Professor Timothy Jamison

Research in the Jamison group is centered on the development of new reactions and technologies for organic synthesis. Towards these themes, the group has pioneered a number of air-stable nickel precatalysts supported by phosphines and N-heterocyclic carbenes that are readily converted to the active catalyst in situ. A variety of carbon-carbon bonding forming reactions promoted by nickel catalysts have also been discovered, including the coupling of different functional groups in a highly regio-, stereo- and enantioselective fashion depending on the nature of the supporting ligands on nickel.

The Jamison group also pursues new chemical methods and technologies under continuous flow conditions to enable reactions that would be difficult or impossible to perform under batch conditions, streamline multistep processes, decrease safety risks to researchers, as well as improve reaction efficiency.

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Standley EA1, Jamison TF.
2013 Jan 30;135(4):1585-92. doi: 10.1021/ja3116718. Epub 2013 Jan 14.
The synthesis and characterization of the air-stable nickel(II) complex trans-(PCy(2)Ph)(2)Ni(o-tolyl)Cl is described in conjunction with an investigation of its use for the Mizoroki-Heck-type, room temperature, internally selective coupling of substituted benzyl chlorides with terminal alkenes. This reaction, which employs a teRead More
Standley EA1, Smith SJ1, Müller P1, Jamison TF1.
2014 Apr 28;33(8):2012-2018. Epub 2014 Apr 16
A series of air-stable nickel complexes of the form L2Ni(aryl) X (L = monodentate phosphine, X = Cl, Br) and LNi(aryl)X (L = bis-phosphine) have been synthesized and are presented as a library of precatalysts suitable for a wide variety of nickel-catalyzed transformations. These complexes are easily synthesized from low-cost NiCRead More
Tasker SZ1, Standley EA1, Jamison TF2.
2014 May 15;509(7500):299-309. doi: 10.1038/nature13274
Tremendous advances have been made in nickel catalysis over the past decade. Several key properties of nickel, such as facile oxidative addition and ready access to multiple oxidation states, have allowed the development of a broad range of innovative reactions. In recent years, these properties have been increasingly understoodRead More