Jin-Quan Yu Group – Professor Product Portal

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Professor Jin-Quan Yu

Congratulations to Dr. Yu for being named a 2016 MacArthur Fellow!

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The Yu program centers around the discovery of catalytic carbon–carbon and carbon–heteroatom bond forming reactions based on C–H activation. Target transformations are selected to enable 1) the use of simple and abundant starting materials such as aliphatic acids, amines and alcohols, and 2) disconnections that drastically shorten the synthesis of a drug molecule or a major class of biologically active compounds. Ultimately, the Yu group hopes to develop catalytic reactions to parallel enzymatic transformations in terms of reactivity and selectivity.

To achieve this goal, their research activities are directed towards the following main aspects: C–H activation, sustainable catalysis, asymmetric catalysis and synthetic applications. Recent publications have highlighted the optimized steric hindrance and electronic effect of directing groups to functionalize ortho- and now meta­-C–H bonds in high yields. By developing versatile ligand-enabled catalytic systems, Jin-Quan Yu has differentiated himself as a thought leader in enantioselective synthesis.

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Ling Chu, Kai-Jiong Xiao, Jin-Quan Yu
Science 2014-10-24
Asymmetric carbon-hydrogen (C-H) activation reactions often rely on desymmetrization of prochiral C-H bonds on the same achiral molecule, using a chiral catalyst. Here, we report a kinetic resolution via palladium-catalyzed enantioselective C-H iodination in which one of the enantiomers of a racemic benzylic amine substrates und...Read More
Peng-Xiang Shen, Xiao-Chen Wang, Peng Wang, Ru-Yi Zhu, Jin-Quan Yu
Journal of the American Chemical Society 2015-09-16
2-Carbomethoxynorbornene is identified as a more effective transient mediator to promote a Pd(II)-catalyzed meta-C(sp(2))-H alkylation of amides with various alkyl iodides as well as arylation with previously incompatible aryl iodides. The use of a tailor-made quinoline ligand is also crucial for this reaction to proceed.Read More
Yongwei Wu, Yan-Qiao Chen, Tao Liu, MartinD Eastgate, Jin-Quan Yu
Journal of the American Chemical Society 2016-10-01
Pd(II)-catalyzed Gamma-C(sp(3))-H arylation of primary amines is realized by using 2-hydroxynicotinaldehyde as a catalytic transient directing group. Importantly, the catalyst and the directing group loading can be lowered to 2% and 4% respectively, thus demonstrating high efficiency of this newly designed transient directing gr...Read More