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Professor Abigail Doyle Professor Ming-Yu Ngai

Ngai lab focuses on the development of novel reagents and radical strategies to access open-shell reactive species for the formation of carbon-carbon and carbon-heteroatom bonds. Redox-active di- and trifluoromethoxylating reagents have been developed for direct conversion of (hetero)aryl C-H group into C-OCF2H and C-OCF3 groups. The mild reaction conditions tolerate a wide range of functional groups and enable late-stage functionalization of drug-like molecules.

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For recent articles from the Ming-Yu Ngai:

Zheng W, Lee JW, Morales-Rivera CA, Liu P, Ngai MY.
Angew Chem Int Ed Engl. 2018 Oct 15;57(42):13795-13799. doi: 10.1002/anie.201808495. Epub 2018 Sep 20.
The trifluoromethoxy (OCF3 ) radical is of great importance in organic chemistry. Yet, the catalytic and selective generation of this radical at room temperature and pressure remains a longstanding challenge. Herein, the design and development of a redox-active cationic reagent (1) that enables the formation of the OCF3 radical in a controllable,...Read More
Lee JW, Lee KN, Ngai MY
Angew Chem Int Ed Engl. 2019 Apr 3. doi: 10.1002/anie.201902243.
The trifluoromethoxy (OCF3) and difluoromethoxy (OCF2H) groups are fluorinated structural motifs that exhibit unique physicochemical characteristics. Incorporation of these substituents into organic molecules is a highly desirable approach used in medicinal chemistry and drug discovery processes to alter the properties of a parent compound....Read More
Lee JW, Zheng W, Morales-Rivera CA, Liu P, Ngai MY.
Chem Sci. 2019 Feb 11;10(11):3217-3222. doi: 10.1039/c8sc05390a. eCollection 2019 Mar 21.
Intermolecular C-H difluoromethoxylation of (hetero)arenes remains a long-standing and unsolved problem in organic synthesis. Herein, we report the first catalytic protocol employing a redox-active difluoromethoxylating reagent 1a and photoredox catalysts for the direct C-H difluoromethoxylation of (hetero)arenes....Read More