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Professor Abigail Doyle Professor Pavel Nagorny

Research in Nagorny group is focused on the areas of organic synthesis and catalysis with the long-term goals of (1) developing and exploring new catalytic transformations, and (2) developing concise syntheses of bioactive natural products (NPs) and using these syntheses as a platform for designing new therapeutic agents for the treatment of human diseases. The design and development of new chiral ligands and catalysts has been one of the important directions in our group. Based on our experiences in chiral phosphoric acid catalysis, our group has designed a new class of spiroketal-based chiral scaffolds termed SPIROLs. The SPIROL-based ligands have demonstrated excellent performance in a variety of Pd-, Rh- and Ir-catalyzed transformations while being easily accessible. Our other efforts in the area of asymmetric catalysis and chiral catalyst and ligand design are dedicated to development of immobilized organic catalysts for catalysis in flow as well as improving the preparation of the existing chiral scaffolds.

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Argüelles AJ, Sun S, Budaitis BG, Nagorny P.
Angew Chem Int Ed Engl. 2018 May 4;57(19):5325-5329. doi: 10.1002/anie.201713304. Epub 2018 Mar 23.
We present an expedient and economical route to a new spiroketal-based C2 -symmetric chiral scaffold, termed SPIROL. Based on this spirocyclic scaffold, several chiral ligands were generated...Read More
Tay JH, Arguelles AJ, Nagorny P
Org Lett. 2015 Aug 7;17(15):3774-7. doi: 10.1021/acs.orglett.5b01754. Epub 2015 Jul 21.
A direct single-step hydrogenation of BINOL-based chiral phosphoric acids, N-triflyl phosphoramides, and disulfonimides to the corresponding H8-BINOL Brønsted acids in excellent yields and chemoselectivities is described...Read More
Tay JH, Argüelles AJ, DeMars MD 2nd, Zimmerman PM, Sherman DH, Nagorny P
J Am Chem Soc. 2017 Jun 28;139(25):8570-8578. doi: 10.1021/jacs.7b03198. Epub 2017 Jun 19.
This work describes the first example of using chiral catalysts to control site-selectivity for the glycosylations of complex polyols such as 6-deoxyerythronolide B and oleandomycin-derived macrolactones...Read More