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Professor Ronald Raines

Professor Ron Raines works with Sigma-Aldrich on the development of reagents and tools for chemical biology such as the traceless Staudinger ligation reagent (670359). DTBA (774405), a superior biological reducing reagent to DTT, is another technology to come out of the Raines lab.  Other exciting research has led to an RNA-cleaving enzyme that is in a multi-site human clinical trial as an anti-cancer agent, revealed that an unappreciated force—the n-to-pi* interaction—stabilizes all proteins, created hyperstable and human-scale synthetic collagens, and established chemical processes to synthesize proteins and convert crude biomass into useful fuels and chemicals.

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John C Lukesh, Michael J Palte, Ronald T Raines
Journal of the American Chemical Society 2012-03-07
Dithiothreitol (DTT) is the standard reagent for reducing disulfide bonds between and within biological molecules. At neutral pH, however, >99% of DTT thiol groups are protonated and thus unreactive. Herein, we report on (2S)-2-amino-1,4-dimercaptobutane (dithiobutylamine or DTBA), a dithiol that can be synthesized from l-aspart...Read More
Michael N Levine, Ronald T Raines
Chemical science (Royal Society of Chemistry : 2010) 2012-01-01
The trimethyl lock is an o-hydroxydihydrocinnamic acid derivative in which unfavorable steric interactions between three pendant methyl groups encourage lactonization to form a hydrocoumarin. This reaction is extremely rapid, even when the electrophile is an amide and the leaving group is an amino group of a small-molecule drug,...Read More
Annie Tam, Ronald T Raines
Methods in Enzymology 2009-01-01
The engineering of proteins can illuminate their biological function and improve their performance in a variety of applications. Within the past decade, methods have been developed that facilitate the ability of chemists to manipulate proteins in a controlled manner. Here, we present the traceless Staudinger ligation as a strate...Read More