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Professor Seth Herzon

The Herzon group has developed highly active catalysts for the anti-Markovnikov hydration and reductive hydration of terminal alkynes to form aldehydes and linear alcohols, respectively. The reductive hydration reaction proceeds by formation of an aldehyde intermediate that is reduced in situ. The catalysts 794120 and 794139, and the dry mixture of ligand and catalyst L511692, are air- and moisture stable. All reactions should be performed in deoxygenated solvents.

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Le Li, Seth B Herzon
Nature Chemistry 2014-01-01
There is currently great interest in the development of multistep catalytic processes in which one or several catalysts act sequentially to rapidly build complex molecular structures...Read More
Le Li, Mingshuo Zeng, Seth B Herzon
Angewandte Chemie (International Edition) 2014-07-21
Anti-Markovnikov alkyne hydration provides a valuable route to aldehydes. Half-sandwich ruthenium complexes ligated by 5,5'-bis(trifluoromethyl)-2,2'-bipyridine are remarkably active for this transformation...Read More
Mingshuo Zeng, Le Li, Seth B Herzon
Journal of the American Chemical Society 2014-05-14
The conversion of terminal alkynes to functionalized products by the direct addition of heteroatom-based nucleophiles is an important aim in catalysis. We report the design, synthesis, and mechanistic studies of the half-sandwich ruthenium complex 12, which is a highly active catalyst for the anti-Markovnikov reductive hydration of alkynes...Read More