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Professor Troels Skrydstrup

The Skrydstrup group has developed reagents and glassware for carrying out transition metal catalyzed carbonylations in a simple and safe manner. Upon treatment with a palladium catalyst, the acid chloride, COgen, liberates carbon monoxide in near quantitative amounts from any aprotic solvent and at a wide temperature range. Its carbon-13 labeled counterpart, 13COgen, provides the 13C-CO under identical conditions.

In combination with the two-chamber reactor, COware, the release of CO in one chamber and its direct application in the second chamber provides a convenient method for running stoichiometric carbonylation reactions without the direct handling of CO. To date, this CO-technique has found application in numerous carbonylation purposes including amino-, alkoxy-, thio- and reductive carbonylations. Furthermore, they have developed conditions for running the carbonylative versions of the Suzuki-Miyaura coupling, the Mizoroki-Heck reaction, the α-arylation and even access to α-ketoamides via a double carbonylation, all by employing the COware-COgen combination. Again, the carbon-13 labeled compounds were obtained by the simple substitution of COgen for 13COgen.

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Thomas M Gøgsig, Rolf H Taaning, Anders T Lindhardt, Troels Skrydstrup
Angewandte Chemie. International edition in English 2012-01-16
Thomas M Gøgsig, Dennis U Nielsen, Anders T Lindhardt, Troels Skrydstrup
Organic Letters 2012-05-18
The direct carbonylative palladium catalyzed synthesis of monoprotected 1,3-ketoaldehydes is reported starting from aryl iodides applying near stoichiometric amounts of carbon monoxide. Besides representing platforms for a variety of heterocyclic structures, these motives serve as viable precursors for the highly relevant aryl m...Read More
Philippe Hermange, Anders T Lindhardt, Rolf H Taaning, Klaus Bjerglund, Daniel Lupp, Troels Skrydstrup
Journal of the American Chemical Society 2011-04-20
A new technique for the ex situ generation of carbon monoxide (CO) and its efficient incorporation in palladium catalyzed carbonylation reactions was achieved using a simple sealed two-chamber system. The ex situ generation of CO was derived by a palladium catalyzed decarbonylation of tertiary acid chlorides using a catalyst ori...Read More