Tomislav Rovis – Professor Product Portal

Professor Product Portal Index

Professor Tomislav Rovis

The Rovis group is interested in a broad scope of catalytic reactions and employs both metal and non-metal catalysts to achieve them. They have had considerable success with rhodium and its use in carbon-carbon bond forming desymmetrization, N-heterocycle synthesis, and most recently, C-H activation. Among their contributions to the field of organocatalysis, the development of N-heterocyclic carbene (NHC) catalysts for the enantioselective Stetter reaction in both intra and intermolecular fashion is one of the most prominent. Their work in this area has led to the development of several related transformations employing NHCs as catalysts, including a method for the preparation of enantioenriched fluorinated carboxylic acid derivatives. These products show significant promise in medicinal applications, as enantiopure fluorine stereocenters are historically difficult to install.

Rovis Group website

For applicable product information, please click below:

For recent articles from the Rovis Laboratory:

Products available from the Rovis Laboratory


Harit U Vora and Tomislav Rovis
Journal of the American Chemical Society, 132(9), 2860-2861 (2010)
Asymmetric hydration of alpha,alpha-dichloro aldehydes and alpha-halo enals via a NHC-catalyzed redox process to yield enantioenriched alpha-chloro and alpha-fluoro carboxylic acids is described herein. The developed reaction allows for installation....Read More
Todd K Hyster et. al
Science, 338(6106), 500-503 (2012)
Enzymes provide an exquisitely tailored chiral environment to foster high catalytic activities and selectivities, but their native structures are optimized for very specific biochemical transformations. Designing a protein to accommodate a non-nativ....Read More
Daniel A DiRocco et. al
Journal of the American Chemical Society, 131(31), 10872-10874 (2009)
The catalytic asymmetric intermolecular Stetter reaction of heterocyclic aldehydes and nitroalkenes has been developed. We have identified a strong stereoelectronic effect on catalyst structure when a fluorine substituent is placed in the backbone....Read More