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Professor Abigail Doyle Professor Arthur Winter

Research in the Winter lab focuses on the development of new chemical tools for biological and medical applications. Philosophically, we take the view that many problems in biology are at heart problems in mechanistic physical organic chemistry. Using a joint theoretical/experimental approach, we design and synthesize chemical tools for biological applications, with a focus on chemical tools that can be manipulated using light.

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Peterson JA, Wijesooriya C, Gehrmann EJ, Mahoney KM, Goswami PP, Albright TR, Syed A, Dutton AS, Smith EA, Winter AH
J Am Chem Soc. 2018 Jun 13;140(23):7343-7346. doi: 10.1021/jacs.8b04040. Epub 2018 May 29.
Photocages are light-sensitive chemical protecting groups that provide external control over when, where, and how much of a biological substrate is activated in cells using targeted light irradiation. Regrettably,...Read More
Goswami PP, Syed A, Beck CL, Albright TR, Mahoney KM, Unash R, Smith EA, Winter AH.
J Am Chem Soc. 2015 Mar 25;137(11):3783-6. doi: 10.1021/jacs.5b01297. Epub 2015 Mar 17.
Photoremovable protecting groups derived from meso-substituted BODIPY dyes release acetic acid with green wavelengths >500 nm. Photorelease is demonstrated in cultured S2 cells...Read More
Slanina T, Shrestha P, Palao E, Kand D, Peterson JA, Dutton AS, Rubinstein N, Weinstain R, Winter AH, Klán P
J Am Chem Soc. 2017 Oct 25;139(42):15168-15175. doi: 10.1021/jacs.7b08532. Epub 2017 Oct 17.
A detailed investigation of the photophysical parameters and photochemical reactivity of meso-methyl BODIPY photoremovable protecting groups was accomplished through systematic variation of the leaving group (LG) and core substituents as well as substitutions at boron...Read More