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Professor William Wulff

The research areas of interest to the Wulff group include enantioselective catalysis, mechanisms of asymmetric catalysis, macromolecular chemistry, Fischer carbene complexes in organic synthesis and the total synthesis of natural products.
The vaulted biaryl ligands VANOL and VAPOL were developed by the Wulff group as topographical alternatives to BINOL and have been demonstrated to be effective in a variety of useful catalytic asymmetric reactions. Noteworthy among these are asymmetric aziridinations and aminoallylations. Finally, hydrogen phosphate derivatives of these ligands have found a number of applications, largely developed by Jon Antilla.

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Anil K Gupta, Munmun Mukherjee, William D Wulff
Organic Letters 2011-11-04
The first multicomponent catalytic asymmetric aziridination reaction is developed to give aziridine-2-carboxylic esters with very high diastereo- and enantioselectivity from aromatic and aliphatic aldehydes. This new method pushes the boundary of the aziridination reaction to substrates that failed with preformed imines. © 2011 ...Read More
Hong Ren, William D Wulff
Journal of the American Chemical Society 2011-04-20
The development of a catalytic asymmetric method for the direct aminoallylation of aldehydes is described that gives high asymmetric inductions for a broad range of substrates including both aromatic and aliphatic aldehydes. This method allows for direct isolation of unprotected analytically pure homoallylic amines without chrom...Read More
Huan Wang, Alexander V Predeus, William D Wulff
Chemistry: A European Journal 2013-06-17
The double benzannulation of bis-carbene complexes of chromium with α,ω-diynes generates [m.n]cyclophanes in which all three rings are generated in a single reaction. This triple annulation process is very flexible allowing for the construction of symmetrical [n.n]cyclophanes and unsymmetrical [m.n]cyclophanes as well as isomers...Read More