[Skip to Content](https://www.sigmaaldrich.com#main-content) [](https://www.sigmaaldrich.com/US/en) Products Cart0 USEN Products ProductsApplicationsServicesResourcesSupport [Analytical Chemistry](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry)[Cell Culture & Analysis](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis)[Chemistry & Biochemicals](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals)[Clinical & Diagnostics](https://www.sigmaaldrich.com/US/en/products/clinical-diagnostics)[Filtration](https://www.sigmaaldrich.com/US/en/products/filtration) [Greener Alternative Products](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/greener-alternative-products) [Industrial Microbiology](https://www.sigmaaldrich.com/US/en/products/industrial-microbiology)[Lab Automation](https://www.sigmaaldrich.com/US/en/products/lab-automation)[Labware](https://www.sigmaaldrich.com/US/en/products/labware)[Materials Science](https://www.sigmaaldrich.com/US/en/products/materials-science)[Molecular Biology & Functional Genomics](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics)[mAbs Development & Manufacturing](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies)[mRNA Development & Manufacturing](https://www.sigmaaldrich.com/US/en/integrated-offerings/mrna-development-manufacturing)[Pharma & Biopharma Manufacturing](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing)[Protein Biology](https://www.sigmaaldrich.com/US/en/products/protein-biology)[Water Purification](https://www.sigmaaldrich.com/US/en/products/water-purification) [Analytical Chemistry](https://www.sigmaaldrich.com/US/en/applications/analytical-chemistry)[Cell Culture & Analysis](https://www.sigmaaldrich.com/US/en/applications/cell-culture-and-cell-culture-analysis)[Chemistry & Synthesis](https://www.sigmaaldrich.com/US/en/applications/chemistry-and-synthesis) [Clinical & Diagnostics](https://www.sigmaaldrich.com/US/en/applications/clinical-testing-and-diagnostics-manufacturing)[Environmental & Cannabis Testing](https://www.sigmaaldrich.com/US/en/applications/environmental-testing-and-industrial-hygiene)[Food & Beverage Testing & Manufacturing](https://www.sigmaaldrich.com/US/en/applications/food-and-beverage-testing-and-manufacturing)[Genomics](https://www.sigmaaldrich.com/US/en/applications/genomics)[Materials Science & Engineering](https://www.sigmaaldrich.com/US/en/applications/materials-science-and-engineering)[Microbiological Testing](https://www.sigmaaldrich.com/US/en/applications/microbiological-testing)[mAbs Development & Manufacturing](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies)[mRNA Development & Manufacturing](https://www.sigmaaldrich.com/US/en/integrated-offerings/mrna-development-manufacturing)[Pharma & Biopharma Manufacturing](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing)[Protein Biology](https://www.sigmaaldrich.com/US/en/applications/protein-biology)[Research & Disease Areas](https://www.sigmaaldrich.com/US/en/applications/research-disease-areas)[Water Purification](https://www.sigmaaldrich.com/US/en/applications/water-purification) [Contract Manufacturing](https://www.sigmaaldrich.com/US/en/services/contract-manufacturing)[Contract Testing](https://www.sigmaaldrich.com/US/en/services/contract-testing)[Custom Products](https://www.sigmaaldrich.com/US/en/services/custom-products)[Digital Solutions for Life Science](https://www.sigmaaldrich.com/US/en/services/software-and-digital-platforms)[IVD Development & Manufacturing](https://www.sigmaaldrich.com/US/en/services/ivd-development-manufacturing)[Product Services](https://www.sigmaaldrich.com/US/en/services/product-services)[Support](https://www.sigmaaldrich.com/US/en/services/support) [Documents](https://www.sigmaaldrich.com/US/en/documents-search?tab=coa) [Learning CenterNew](https://www.sigmaaldrich.com/US/en/life-science/learning-center) [Customer Support](https://www.sigmaaldrich.com/US/en/support/customer-support) [Contact Us](https://www.sigmaaldrich.com/US/en/collections/offices) [Get Site Smart](https://www.sigmaaldrich.com/US/en/life-science/ecommerce/website-update-info) [FAQ](https://maestro.my.site.com/knowledgeportal/s/) [Quality & Regulatory](https://www.sigmaaldrich.com/US/en/life-science/quality-and-regulatory-management) [Calculators & Apps](https://www.sigmaaldrich.com/US/en/support/calculators-and-apps) [Webinars](https://www.sigmaaldrich.com/US/en/collections/webinars) [Login / Register](https://www.sigmaaldrich.com/oidc-sign-in) [Order Lookup](https://www.sigmaaldrich.com/US/en/order-lookup) [Quick Order](https://www.sigmaaldrich.com/US/en/quick-order) Cart0 [Home](https://www.sigmaaldrich.com/US/en)[Organic Electronics](https://www.sigmaaldrich.com/US/en/applications/materials-science-and-engineering/organic-electronics)Mechanochemical Effect of Severe Plastic Deformations: Metal Alloys, Hydrides and Molecular Solids # Mechanochemical Effect of Severe Plastic Deformations: Metal Alloys, Hydrides and Molecular Solids __Jacques Huot1, Viktor Balema2__ 1Hydrogen Research Institute, Université du Québec à Trois-Rivières, Trois-Rivières, 3351, des Forges Blvd., PO Box 500, QC, G9A 5H7, Canada, 2MilliporeSigma, 6000 N. Teutonia Ave, Milwaukee, WI, 53209, USA *Material Matters, Volume 5 Article 4* ## Introduction[](https://www.sigmaaldrich.com) Hydrogen, as an alternative to a traditional energy vector such as oil, coal and natural gas, has been the focus of research and development efforts in all technologically advanced countries of the world. It is strongly believed that a hydrogen-based economy can resolve energyrelated problems and slow down global climate change. Hydrogen can be produced from a variety of renewable sources, is non-toxic and as an energy carrier, extremely environmentally benign. However, despite apparent benefits, an immediate incorporation of hydrogen into the world economy faces serious challenges. Although it is routinely used by chemical and refining industries, the cost of hydrogen storage and delivery is too high for the majority of energy applications. Yet, storing hydrogen in solids, metal alloys and hydrides offers a unique opportunity for its convenient and safe use in a variety of portable and stationary applications. This article gives a brief overview of an experimental approach that is used for the preparation and processing of metallic hydrogen storage materials. The approach employs the chemical effect of plastic deformations for nano-scale design and modification of hydrogen absorbing metals and alloys.1 The paper specifically focuses on the methods which introduce severe plastic deformation (SPD) into metal alloys and metal hydrides, and compares SPD to another mechanical processing technique–ball milling. Finally, it also highlights a possible role of plastic deformations in mechanically induced transformations of hydrogen-rich molecular solids, which recently attracted a great deal of interest.2 ## Severe Plastic Deformations in the Preparation of Metal Hydrides[](https://www.sigmaaldrich.com) Severe plastic deformations can be introduced into metallic and intermetallic systems using several relatively simple but very efficient techniques such as: equal channel angular pressing (ECAP), highpressure torsion (HPT) or cold rolling (CR). Similar to high-energy ball milling,2 these techniques were initially developed for the forming and processing of metals but proved to be efficient tools for the preparation and modification of hydrogen storage materials. *__Equal Channel Angular Pressing (ECAP)__* introduces severe plastic deformations into the material by forcing a sample (billet) through a die consisting of two channels of equal cross-section, which intersect at an angle between 90° and 120°.3 (__Figure__ __1__)  __Figure 1.__Schematic illustration of Equal Channel Angular Pressing (ECAP) Since the billet assumes the form and cross-section of the die, it can be repeatedly processed to increase the microstrain and reduce the size of crystallites in the material. In addition, by simply rotating the billet between successive pressings, different slip systems could be activated in the sample. ECAP efficiently processes metals as it enables the production of porosity-free materials with average crystallite sizes between 2 μm and 100 nm in substantial quantities with lower concentration of impurities and at a lower cost than conventional ball milling.4 ECAP has been directly compared to ball milling by Skripnyuk et al., who studied the kinetics and thermodynamics of hydrogen sorption in commercial ZK60 alloy (94.34 wt.% Mg, 4.95 wt.% Zn, 0.71 wt.% Zr) processed by ECAP and/or ball milling.5 Although ECAP proved to be quite efficient in enhancing hydrogen absorption and desorption ability of the alloy, the highest effect was achieved when it was combined with high-energy milling. In another similar study, the investigation of a commercial magnesium alloy AZ31 (96 wt.% Mg, 3 wt.% Al, 1 wt.% Zn) processed by ECAP between 423 K and 573 K,6 also revealed that the optimal hydrogen absorption and desorption parameters of AZ31 were obtained when three different mechanical processing techniques \[ECAP, cold rolling (CR), and high-energy ball milling] were combined. Thus, it seems safe to assume that the full advantage of ECAP can be taken if it is combined with other processing techniques, rather than when it is used alone. In the case of __*High Pressure Torsion (HPT)*__ processing, a powder or thin film material is subjected to a high pressure and a concurrent torsion straining (__Figure 2__).  __Figure 2.__Schematic illustration of High Pressure Torsion (HPT). s HPT is generally restricted to small (sub-gram scale) samples, it is mainly used to evaluate fundamental effects of SPD in solid materials. One such study was performed by Kusadome, et al. on MgNi2 alloy,7 which does not usually absorb hydrogen. However, after the HPT processing introduced a substantial strain in the material, it became a weak hydrogen absorber (0.1 wt.%) with hydrogen accumulating in grain boundaries of the alloy.7 In another experiment, Lima, et al. observed a substantial improvement in the hydrogen sorption kinetics of a Mg-Fe powder mixture processed by HPT.8 They noted that the hydrogenation and dehydrogenation of the processed samples did not affect the preferential (002) orientation of the Mg phase, i.e., the material retained the microstructure imposed by HPT. Similarities between HPT and ball milling were evidenced in the recent work by Leiva, et al. who detected the formation of a metastable γ-MgH2 phase and a substantial reduction of crystallite sizes in magnesium hydride, while using HPT to consolidate the metal hydride powder.9 Previously, the formation of γ-MgH2 upon mechanical processing was chiefly associated with high-energy ball milling.10 In Cold Rolling (CR) a sheet of metal is introduced between rollers where it is compressed and squeezed through the roller (__Figure 3__).  __Figure 3.__Schematic illustration of Cold Rolling (CR) The amount of strain introduced by CR determines the hardness and other properties of the finished product.11 Usually, rolling is classified according to the processing temperature as compared with the metal re-crystallization temperature: • Hot rolling (HR) is the process carried out at a temperature exceeding the re-crystallization temperature of the rolled material • Cold rolling (CR) is usually performed at a temperature below the re-crystallization temperature The effect of cold rolling on hydrogen sorption properties of hydrogen storage alloys has been studied in detail.12-14 Zhang et al., investigated the effect of deformations on hydrogen sorption behavior of Ti-based alloys.12, 13 In their experiments, deformations in the material were generated by cold rolling or compression. It turned out that the first hydrogenation (activation) of the cold-rolled alloys was much faster than that of the unprocessed (as-quenched) samples. Unfortunately, this positive effect of CR disappeared after a few hydrogenation/ dehydrogenation cycles as the material returned to its initial state. Couillaud, et al. investigated the effect of a multiple CR on the hydrogen absorption properties of TiV1.6Mn0.4 and compared it to a high-energy ball milling.14 The study revealed that cold rolling and ball milling had a similar effect–both techniques caused the reduction of crystallite sizes and the lattice parameters of the alloy without changing its crystal structure. S. Kikuchi′s group investigated the effect of CR on the hydrogen storage ability of various Mg-based multi-component alloys.15 For the Mg-Ni system, they found that a Mg-Ni laminated composite, subjected to an additional heat treatment, transforms into the intermetallic alloy Mg2Ni, which upon exposure to hydrogen can be converted into the metal hydride–Mg2NiH4. The composition 2Mg+Ni was also studied by Pedneault, et al., who investigated the effect of cold rolling on the electrochemical properties of the processed alloys.16 They found that a combination of CR with an additional heat treatment is a promising approach to the preparation of nanostructured metal hydrides. The nanocrystalline Mg2Ni prepared by cold rolling showed electrochemical performance similar to that of nanocrystalline Mg2Ni powder made by high-energy ball milling from magnesium and nickel. In another example, the laminated Mg-Pd composite materials demonstrate faster activation and better air resistance than the ballmilled samples of the same stoichiometry.17 ## Cold Rolling of Magnesium and Magnesium Hydride[](https://www.sigmaaldrich.com) Similar to HPT and high-energy ball milling, cold rolling of MgH2 ([683043](https://www.sigmaaldrich.com/US/en/product/aldrich/683043)) facilitates the formation of the metastable γ-MgH2 phase in magnesium hydride, thus indicating that CR should be at least as energetic as other processing techniques discussed above.9 In recent experiments, J. Huot′s group compared the effects of CR and high-energy ball milling on the hydrogen absorption properties of magnesium hydride. Figure 4 shows the hydrogen absorption kinetics of an *as-received* magnesium hydride and the samples obtained by ballmilling (for 30 min) or cold rolling (for 5 times).  __Figure 4.__Hydrogen absorption kinetic at 623 K and under 2 MPa hydrogen pressure of MgH2 in as-received, cold rolled five times (CR5X), and mechanically milled (BM30mins) states. The untreated magnesium hydride has very slow absorption/desorption kinetics and ball milling for 30 minutes considerably enhances it. Remarkably, the cold rolled sample demonstrates similar kinetics to that of the ball milled material, despite the fact that the rolling was performed in air while the ball-milling was carried out under argon to prevent the material′s oxidation during processing. Thus, cold rolling offers a simple and economical way to modify magnesium, compared to the more expensive and time consuming high-energy ball milling. It can be expected that the severe strain associated with severe plastic deformations in hydride forming metals, such as magnesium and its alloys, could generate a variety of defects that serve as a nucleation point for the hydride phase. To test this hypothesis, cold rolled magnesium and a commercial magnesium alloy AZ91 (~92% of Mg and ~8% of Al with minor additions of Zn, Mn and Si) were investigated. Each sample was folded and rolled 50 times then exposed to hydrogen. As a reference, a pure untreated magnesium powder was exposed to hydrogen under the same conditions. __Figure 5__ shows the hydrogen absorption (activation) curves collected at 623 K under the hydrogen pressure of 20 bar.  __Figure 5.__ First hydrogenation (activation) curves of magnesium powder, cold rolled magnesium (Mg ingot) and cold rolled commercial alloy (AZ91 ingot). Activation was performed at 623 K under a hydrogen pressure of 20 bar. As expected, cold-rolled activated samples demonstrate considerably higher ability to absorb hydrogen in the activation cycle than the untreated magnesium powder. In addition, the rolled samples start to absorb immediately after the exposure to hydrogen, while the absorption by the untreated powder has a long incubation time. ## Mechnically Induced Transformations of Molecular Solids[](https://www.sigmaaldrich.com) The experimental results presented above clearly demonstrate that severe plastic deformations introduced into metallic materials by Equal Channel Angular Pressing, High Pressure Torsion or Cold Rolling significantly enhance the ability of metals to interact with each other and/or with hydrogen. In other words, severe plastic deformations facilitate mechanically induced chemical transformations in metals and metal hydrides and allow the synthesis of metal alloys and hydride phases ranging from solid solutions to binary and complex metal hydrides (such as Mg2NiH4 or MgH2). It is also safe to assume that the effect of SPD is similar to that of mechanical milling with the major difference being that SPD techniques may offer a less expensive and more scalable way to carry out mechanically activated processes. To further understand the relationship between SPD and ball milling, it may be helpful to look into the changes that occur in a solid material trapped between colliding balls or balls and container walls during a high-energy ball-mill process. Once trapped between the balls, solid material is subjected to an external pressure causing a sequence of deformations (__Figure 6__) which starts with reversible elastic deformations followed by irreversible plastic deformations, such as shear and twist deformations. As pressure increases, the latter becomes quite severe and lead to the fracture and/or amorphization of the material.2  __Figure 6.__Deformations in the material trapped between two colliding balls during ball milling. Thus, the character of deformations caused by ball milling are quite similar to those introduced by SPD techniques, which may explain the similarities between these mechanical processing techniques. For high-energy ball milling, an additional factor to consider is the highpressure generated within the material trapped between the colliding balls and the walls of the milling container. The pressure in such contact areas may reach several GPa,2 making it sufficient to facilitate pressuredriven chemical transformations in metals, ionic hydrides or molecular (organic) solids. However, in a number of cases, very similar chemical reactions are known to occur under conditions that may or may not generate high-pressure spots, but certainly introduce severe plastic deformations into the processed materials. For example, the highenergy ball milling of a mixture of solid phosphonium salts and solid organic aldehydes in the presence on potassium carbonate enables the solvent-free Wittig reaction (__Figure 7__).18  __Figure 7.__The mechanically induced solvent-free Wittig reaction. Initially, the high-pressure generated in the material during ball milling was held responsible for the effect.[2](https://www.sigmaaldrich.com/technical-documents/articles/material-matters/mechanochemical-effect#ref) However, further experiments revealed that the use of ball milling is not crucial for this mechanochemical process and the solvent-free Wittig reactions can be run by grinding the reactants with pestle and mortar,[19](https://www.sigmaaldrich.com/technical-documents/articles/material-matters/mechanochemical-effect.html#ref) which shouldn′t generate the ultra-high pressure in the material but is certainly a source of severe plastic deformations similar to those introduced by CR or HPT. ## Conclusions[](https://www.sigmaaldrich.com) This review of the effects of SPD on the properties of solid materials clearly demonstrates the efficiency of SPD in the preparation and modification of metallic, ionic and molecular solids. For magnesium and magnesium alloys specifically, SPD can enhance the hydrogen storage ability of these materials and improves their hydrogen storage capacities on the first hydrogenation/dehydrogenation (activation) cycle. A similar effect of SPD is also observed for the cold-rolled magnesium hydride. It seems quite feasible that the severe plastic deformations may be also responsible for the chemical effect of mechanical processing of molecular solids, including such complex multi-step transformations as the mechanically-induced, solvent-free Wittig reaction. Amongst the various SPD techniques, cold rolling is arguably the easiest to scale-up to an industrial level. Therefore, it may supersede high-energy milling for the production of nanocrystalline metallic and ionic materials and can likely also be applied to the conversion of molecular (organic) solids. The studies into the application of SPD in materials chemistry of solid materials are at the very early stages of their development and a substantial additional effort is needed to exploit the full potential of this mechanochemical technique. ## Acknowledgments[](https://www.sigmaaldrich.com) We would like to thank Y. Turcotte, J. Lang and Dr. S. Amira at Université du Québec à Trois-Rivières for help in the study of the effect of SPD. ## Materials Sorry, an unexpected error has occurred Response not successful: Received status code 500 ### References 1\. Valiev R, Islamgaliev R, Alexandrov I. 2000. Bulk nanostructured materials from severe plastic deformation. Progress in Materials Science. 45(2):103-189. [https://doi.org/10.1016/s0079-6425(99)00007-9](https://doi.org/10.1016/s0079-6425%2899%2900007-9) 2\. Balema, V. P., Material Matters, 2007, Vol. 2, No. 1, 16. . \[Internet]. 3\. Skripnyuk V, Rabkin E, Estrin Y, Lapovok R. 2009. Improving hydrogen storage properties of magnesium based alloys by equal channel angular pressing. International Journal of Hydrogen Energy. 34(15):6320-6324. [https://doi.org/10.1016/j.ijhydene.2009.05.136](https://doi.org/10.1016/j.ijhydene.2009.05.136) 4\. 10.1016/j.ijhydene.2009.05.136. \[Internet]. 5\. Skripnyuk V, Rabkin E, Estrin Y, Lapovok R. 2004. The effect of ball milling and equal channel angular pressing on the hydrogen absorption/desorption properties of Mg?4.95 wt% Zn?0.71 wt% Zr (ZK60) alloy. Acta Materialia. 52(2):405-414. [https://doi.org/10.1016/j.actamat.2003.09.025](https://doi.org/10.1016/j.actamat.2003.09.025) 6\. Leiva DR, Fruchart D, Bacia M, Girard G, Skryabina N, Villela AC, Miraglia S, Santos DS, Botta WJ. 2009. Mg alloy for hydrogen storage processed by SPD. IJMR. 100(12):1739-1746. [https://doi.org/10.3139/146.110225](https://doi.org/10.3139/146.110225) 7\. Kusadome Y, Ikeda K, Nakamori Y, Orimo S, Horita Z. 2007. Hydrogen storage capability of MgNi2 processed by high pressure torsion. Scripta Materialia. 57(8):751-753. [https://doi.org/10.1016/j.scriptamat.2007.06.042](https://doi.org/10.1016/j.scriptamat.2007.06.042) 8\. Lima G, Jorge Jr. A, Leiva D, Kiminami C, Bolfarini C, Botta W. 2008. THE 13TH INTERNATIONAL CONFERENCE ON RAPIDLY QUENCHED AND METASTABLE MATERIALS. Journal of Physics: Conference Series, Volume 144 ; Dresden, Germany 9\. Leiva DR, Jorge AM, Ishikawa TT, Huot J, Fruchart D, Miraglia S, Kiminami CS, Botta WJ. 2010. Nanoscale Grain Refinement and H-Sorption Properties of MgH2 Processed by High-Pressure Torsion and Other Mechanical Routes. Adv. Eng. Mater.. 12(8):786-792. [https://doi.org/10.1002/adem.201000030](https://doi.org/10.1002/adem.201000030) 10\. Huot J, Swainson I, Schulz R. 2006. Phase transformation in magnesium hydride induced by ball milling. Ann. Chim. Sci. Mat.. 31(1):135-144. [https://doi.org/10.3166/acsm.31.135-144](https://doi.org/10.3166/acsm.31.135-144) 11\. Jiang WH, Atzmon M. 2005. Mechanical strength of nanocrystalline/amorphous Al90Fe5Gd5 composites produced by rolling. Appl. Phys. Lett.. 86(15):151916. [https://doi.org/10.1063/1.1897434](https://doi.org/10.1063/1.1897434) 12\. Zhang L, Ito K, Vasudevan V, Yamaguchi M. 2001. Hydrogen absorption and desorption in a B2 single-phase Ti?22Al?27Nb alloy before and after deformation. Acta Materialia. 49(5):751-758. [https://doi.org/10.1016/s1359-6454(00)00400-6](https://doi.org/10.1016/s1359-6454%2800%2900400-6) 13\. Zhang L, Ito K, Vasudevan V, Yamaguchi M. 2002. Effects of cold-rolling on the hydrogen absorption/desorption behaviour of Ti?22Al?27Nb alloys. Materials Science and Engineering: A. 329-331362-366. [https://doi.org/10.1016/s0921-5093(01)01601-x](https://doi.org/10.1016/s0921-5093%2801%2901601-x) 14\. Couillaud S, Enoki H, Amira S, Bobet J, Akiba E, Huot J. 2009. Effect of ball milling and cold rolling on hydrogen storage properties of nanocrystalline TiV1.6Mn0.4 alloy. Journal of Alloys and Compounds. 484(1-2):154-158. [https://doi.org/10.1016/j.jallcom.2009.05.037](https://doi.org/10.1016/j.jallcom.2009.05.037) 15\. Ueda TT, Tsukahara M, Kamiya Y, Kikuchi S. 2005. Preparation and hydrogen storage properties of Mg?Ni?Mg2Ni laminate composites. Journal of Alloys and Compounds. 386(1-2):253-257. [https://doi.org/10.1016/j.jallcom.2004.04.154](https://doi.org/10.1016/j.jallcom.2004.04.154) 16\. Pedneault S, Huot J, Roué L. 2008. Nanostructured Mg2Ni materials prepared by cold rolling and used as negative electrode for Ni?MH batteries. Journal of Power Sources. 185(1):566-569. [https://doi.org/10.1016/j.jpowsour.2008.06.077](https://doi.org/10.1016/j.jpowsour.2008.06.077) 17\. Takeichi N, Tanaka K, Tanaka H, Ueda TT, Kamiya Y, Tsukahara M, Miyamura H, Kikuchi S. 2007. Hydrogen storage properties of Mg/Cu and Mg/Pd laminate composites and metallographic structure. Journal of Alloys and Compounds. 446-447543-548. [https://doi.org/10.1016/j.jallcom.2007.04.220](https://doi.org/10.1016/j.jallcom.2007.04.220) 18\. Balema VP, Wiench JW, Pruski M, Pecharsky VK. 2002. Mechanically Induced Solid-State Generation of Phosphorus Ylides and the Solvent-Free Wittig Reaction. J. Am. Chem. Soc.. 124(22):6244-6245. [https://doi.org/10.1021/ja017908p](https://doi.org/10.1021/ja017908p) 19\. Leung SH, Angel SA. 2004. Solvent-Free Wittig Reaction: A Green Organic Chemistry Laboratory Experiment. J. Chem. Educ.. 81(10):1492. [https://doi.org/10.1021/ed081p1492](https://doi.org/10.1021/ed081p1492) __Related Articles__ - [Azide Building Blocks for Chemical Ligation](https://www.sigmaaldrich.com/US/en/technical-documents/technical-article/chemistry-and-synthesis/reaction-design-and-optimization/new-azide-building) - [3D and 4D Printing Technologies](https://www.sigmaaldrich.com/US/en/technical-documents/technical-article/materials-science-and-engineering/3d-printing/3d-and-4d-printing-technologies) - [Inkjet Printing for Printed Electronics](https://www.sigmaaldrich.com/US/en/technical-documents/technical-article/materials-science-and-engineering/3d-printing/inkjet-printing) - [Alternative Energy Tutorial](https://www.sigmaaldrich.com/US/en/technical-documents/technical-article/materials-science-and-engineering/batteries-supercapacitors-and-fuel-cells/tutorial) - [Conducting Polymer Device Applications](https://www.sigmaaldrich.com/US/en/technical-documents/technical-article/materials-science-and-engineering/bioelectronics/applications-of-conducting-polymer-devices-in-life-sciences) - [Conductive Polymers for Advanced Micro- and Nano-fabrication Processes](https://www.sigmaaldrich.com/US/en/technical-documents/technical-article/materials-science-and-engineering/bioelectronics/conductive-polymers) - [Graphene in Biotechnology](https://www.sigmaaldrich.com/US/en/technical-documents/technical-article/materials-science-and-engineering/bioelectronics/graphene-in-biotechnology) - [Electronic and Biomedical Applications of High-Purity Single-Walled Nanotubes (SWNTs)](https://www.sigmaaldrich.com/US/en/technical-documents/technical-article/materials-science-and-engineering/bioelectronics/nanointegris) - [View More](https://www.sigmaaldrich.com/US/en/search/facet-search?focus=sitecontent&term=facet-search) __Related Product Categories__ - [Reducing Agents](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/chemical-synthesis/reducing-agents) - [Inorganic Catalysts](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/catalysts/inorganic-catalysts) - [Ammonium in Sewage Sludge](https://www.sigmaaldrich.com/US/en/technical-documents/protocol/analytical-chemistry/photometry-and-reflectometry/ammonium-in-sewage-sludge) - [Ammonium in Wastewater](https://www.sigmaaldrich.com/US/en/technical-documents/protocol/analytical-chemistry/photometry-and-reflectometry/ammonium-in-wastewater) - [Analytical Method: Analytical Quality Assurance, Standard for COD/Chloride](https://www.sigmaaldrich.com/US/en/technical-documents/protocol/analytical-chemistry/photometry-and-reflectometry/analytical-quality-assurance-standard-for-cod-chloride) - [Nitrate in Fruit Juices](https://www.sigmaaldrich.com/US/en/technical-documents/protocol/analytical-chemistry/photometry-and-reflectometry/nitrate-in-fruit-juices) - [Nitrate in Vegetables](https://www.sigmaaldrich.com/US/en/technical-documents/protocol/analytical-chemistry/photometry-and-reflectometry/nitrate-in-vegetables) - [Nitrate in Wastewater](https://www.sigmaaldrich.com/US/en/technical-documents/protocol/analytical-chemistry/photometry-and-reflectometry/nitrate-in-wastewater) - [View More](https://www.sigmaaldrich.com/US/en/search/facet-search?focus=sitecontent&term=facet-search) Top __Sign In To Continue__ To continue reading please sign in or create an account. Sign In__Don't Have An Account?__Register Support[Customer Support](https://www.sigmaaldrich.com/US/en/support/customer-support)[Contact Us](https://www.sigmaaldrich.com/US/en/collections/offices)[FAQ](https://maestro.my.site.com/knowledgeportal/s/)[Safety Data Sheets (SDS)](https://www.sigmaaldrich.com/US/en/documents-search?tab=sds)[Certificates (COA/COO)](https://www.sigmaaldrich.com/US/en/documents-search?tab=coa)[Quality & Regulatory](https://www.sigmaaldrich.com/US/en/life-science/quality-and-regulatory-management)[Calculators & Apps](https://www.sigmaaldrich.com/US/en/support/calculators-and-apps)[Webinars](https://www.sigmaaldrich.com/US/en/collections/webinars) Orders[Order Lookup](https://www.sigmaaldrich.com/US/en/order-lookup)[Quick Order](https://www.sigmaaldrich.com/US/en/quick-order)[Custom Products](https://www.sigmaaldrich.com/US/en/services/custom-products)[eCommerce Solutions](https://www.sigmaaldrich.com/US/en/life-science/ecommerce/ecommerce-solutions) Company[About Us](https://www.sigmaaldrich.com/US/en/life-science/about-us)[Responsibility](https://www.sigmaaldrich.com/US/en/life-science/ssbi)[Events](https://www.sigmaaldrich.com/US/en/collections/events)[Press Releases](https://www.sigmaaldrich.com/US/en/collections/press)[Programs](https://www.sigmaaldrich.com/US/en/life-science/partnership-programs)[Careers](https://careers.merckgroup.com/global/en)[Offices](https://www.sigmaaldrich.com/US/en/collections/offices) Social Media [](https://www.linkedin.com/company/milliporesigma) [](https://x.com/MilliporeSigma) [](https://www.facebook.com/MilliporeSigma) [](https://www.instagram.com/milliporesigma/) [](https://www.youtube.com/@milliporesigma2407/featured) MilliporeSigma __Research. Development. Production.__ We are a leading supplier to the global Life Science industry with solutions and services for research, biotechnology development and production, and pharmaceutical drug therapy development and production. [](https://www.sigmaaldrich.com/US/en) [Sigma-Aldrich® Solutions](https://www.sigmaaldrich.com/US/en/life-science/sigma-aldrich)[BioReliance® Solutions](https://www.sigmaaldrich.com/US/en/life-science/bioreliance)[Millipore® Solutions](https://www.sigmaaldrich.com/US/en/life-science/millipore)[SAFC® Solutions](https://www.sigmaaldrich.com/US/en/life-science/safc)[Milli-Q® Solutions](https://www.sigmaaldrich.com/US/en/life-science/milliq)[Supelco® Solutions](https://www.sigmaaldrich.com/US/en/life-science/supelco) © 2026 Merck KGaA, Darmstadt, Germany and/or its affiliates. All Rights Reserved, including Text and Data Mining for AI training and similar technologies. Reproduction of any materials from the site is strictly forbidden without permission. [Site Use Terms](https://www.sigmaaldrich.com/US/en/life-science/legal/site-use-terms)|[Privacy Policy](https://www.sigmaaldrich.com/US/en/life-science/legal/privacy-statement)|[General Terms and Conditions of Sale](https://www.sigmaaldrich.com/US/en/life-science/legal/terms-and-conditions)|[Copyright Consent](https://www.sigmaaldrich.com/US/en/life-science/legal/copyright-consent) |[Site Map](https://www.sigmaaldrich.com/US/en/site-map) An unknown error has occured. - English - EN - Español - ES [Learn More](https://www.sigmaaldrich.com) - Products - [Analytical Chemistry](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry) - [Analytical Chromatography](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/analytical-chromatography) - [Analytical Syringes](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/analytical-chromatography/analytical-syringes) - [Analytical Vials](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/analytical-chromatography/analytical-vials) - [Carbon Adsorbents](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/analytical-chromatography/carbon-adsorbents) - [Chromatography Standards](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/reference-materials/chromatography-standards) - [GC Columns, Accessories & Adsorbents](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/analytical-chromatography/gc-columns-accessories-and-adsorbents) - [HPLC Buffers](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/analytical-chromatography/hplc-buffers) - [HPLC Columns](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/analytical-chromatography/hplc-columns) - [LPLC Media & Accessories](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/analytical-chromatography/lplc-media-and-accessories) - [Purge Traps](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/analytical-sample-preparation/purge-traps) - [Solvents](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/analytical-chromatography/solvents) - [TLC Plates & Adsorbents](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/analytical-chromatography/tlc-plates-and-adsorbants) - [Analytical Reagents](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/analytical-reagents) - [Acids](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/lab-chemicals/acids) - [Analytical Syringes](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/analytical-chromatography/analytical-syringes) - [Analytical Vials](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/analytical-chromatography/analytical-vials) - [Caustic Alkalis & Bases](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/lab-chemicals/caustic-alkalis-and-bases) - [Chromatography & Spectroscopy Reagents](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/analytical-reagents/chromatography-spectroscopy-reagents) - [Colorimetric & Titrimetric Test Kits](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/photometry-and-rapid-chemical-testing/colorimetric-and-titrimetric-test-kits) - [Indicators](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/analytical-reagents/indicators) - [Karl Fischer Reagents](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/analytical-reagents/karl-fischer-reagents) - [Karl Fischer Standards](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/reference-materials/karl-fischer-standards) - [Metals](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/lab-chemicals/metals) - [pH Test Strips, pH Papers, Readers & Accessories](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/photometry-and-rapid-chemical-testing/ph-test-strips-paper-readers-and-accessories) - [Salts](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/lab-chemicals/salts) - [Solvents](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/analytical-chromatography/solvents) - [Spectroquant Photometry Instruments, Kits, & Accessories](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/photometry-and-rapid-chemical-testing/photometry-instruments-kits-and-accessories) - [Test Strips, Papers & Readers](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/photometry-and-rapid-chemical-testing/test-strips-papers-and-readers) - [Titration Reagents](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/analytical-reagents/titration-reagents) - [Analytical Sample Preparation](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/analytical-sample-preparation) - [Air Monitoring Devices & Tubes](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/analytical-sample-preparation/air-monitoring-devices-and-tubes) - [Laboratory Filter Holders](https://www.sigmaaldrich.com/US/en/products/filtration/laboratory-filter-holders) - [Millipore^® Lab Filter Membranes](https://www.sigmaaldrich.com/US/en/products/filtration/laboratory-filter-membranes/millipore-filter-membranes) - [Millex^® Syringe Filters](https://www.sigmaaldrich.com/US/en/products/filtration/laboratory-syringe-filters/millex-syringe-filters) - [Purge Traps](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/analytical-sample-preparation/purge-traps) - [Solid Phase Extraction (SPE) & QuEChERS](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/analytical-sample-preparation/spe-and-quechers) - [Solid Phase Micro-Extraction (SPME)](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/analytical-sample-preparation/spme-fibers-and-accessories) - [Supported Liquid Extraction (SLE) Columns, Resins & Accessories](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/analytical-sample-preparation/sle-columns-resins-and-accessories) - [Lab Safety](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/lab-safety) - [Labware Detergents & Cleaners](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/lab-safety/cleaning-detergents) - [Safe Handling](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/lab-safety/safe-handling) - [Safety Accessories](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/lab-safety/safety-accessories) - [Spillage Absorption](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/lab-safety/spillage-absorption) - [Photometry & Rapid Chemical Testing](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/photometry-and-rapid-chemical-testing) - [Colorimetric & Titrimetric Test Kits](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/photometry-and-rapid-chemical-testing/colorimetric-and-titrimetric-test-kits) - [pH Test Strips, pH Papers, Readers & Accessories](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/photometry-and-rapid-chemical-testing/ph-test-strips-paper-readers-and-accessories) - [Photometry Instruments, Test Kits & Accessories](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/photometry-and-rapid-chemical-testing/photometry-instruments-kits-and-accessories) - [Test Strips, Papers & Readers](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/photometry-and-rapid-chemical-testing/test-strips-papers-and-readers) - [Turbidimetric Analysis](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/photometry-and-rapid-chemical-testing/turbiquant-turbidimetric-analysis) - [Reference Materials](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/reference-materials) - [Amino Acid, Peptide & Protein Standards](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/reference-materials/amino-acid-peptide-and-protein-standards) - [Biomarker & Metabolite Standards](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/reference-materials/biomarker-and-metabolite-standards) - [Cannabis Standards](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/reference-materials/cannabis-standards) - [Carbohydrate Standards](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/reference-materials/carbohydrate-standards) - [Certified Reference Materials](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/reference-materials/certified-reference-materials) - [Chromatography Standards](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/reference-materials/chromatography-standards) - [Food Additive Standards](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/reference-materials/food-additive-standards) - [Food & Cosmetic Component Standards](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/reference-materials/food-and-cosmetic-component-standards) - [ICP & AAS Standards](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/reference-materials/icp-and-aas-standards) - [Inorganic Elemental Impurity Mix Standards](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/reference-materials/inorganic-elemental-impurity-mix-standards) - [Ion Chromatography Standards](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/reference-materials/ion-chromatography-standards) - [Karl Fischer Standards](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/reference-materials/karl-fischer-standards) - [Lipid Standards](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/reference-materials/lipid-standards) - [Matrix Materials Standards](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/reference-materials/matrix-materials-standards) - [Microbiology Standards](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/reference-materials/microbiology-standards) - [Organic Pollutant Standards](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/reference-materials/organic-pollutant-standards) - [Pesticide Standards](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/reference-materials/pesticide-standards) - [Petrochemical Standards](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/reference-materials/petrochemical-standards) - [Pharma Standards](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/reference-materials/pharma-secondary-standards) - [Pharmaceuticals, Illicit Drugs & Diagnostic Biomarkers](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/reference-materials/pharmaceuticals-illicit-drugs-and-diagnostic-biomarkers) - [Pharmacopeia & Metrological Institutes Standards](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/reference-materials/pharmacopeia-and-metrological-institutes-standards) - [Physical & Chemical Properties Standards](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/reference-materials/physical-property-standards) - [Phytochemical Standards](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/reference-materials/phytochemical-standards) - [Vitamin Standards](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/reference-materials/vitamin-standards) - [Cell Culture & Analysis](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis) - [3D Cell Culture](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/3d-cell-culture) - [Hydrogels](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/3d-cell-culture/hydrogels) - [Organoids](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/3d-cell-culture/organoids) - [Scaffolds](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/3d-cell-culture/scaffolds) - [Animal Component Free Cell Culture Reagents](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/animal-component-free-cell-culture-reagents) - [Cell Analysis](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/cell-analysis) - [Cell Counting Equipment](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/cell-analysis/cell-counting-equipment) - [Cell Health Analysis](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/cell-analysis/cell-health-analysis) - [Cell Imaging Instruments](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/cell-analysis/cell-imaging-instruments) - [Cell Isolation Kits](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/cell-analysis/cell-isolation-kits) - [Cell Migration & Invasion Assays](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/cell-analysis/cell-migration-and-invasion-assays) - [Live Cell Imaging Reagents](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/cell-analysis/live-cell-imaging-reagents) - [Cell Culture Media & Buffers](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/cell-culture-media-and-buffers) - [Bioprocessing Cell Culture Media](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/bioprocessing-cell-culture/bioprocessing-cell-culture-media) - [Bioprocessing Liquid Cell Culture Media & Buffers](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/bioprocessing-formulation-raw-materials/liquid-cell-culture-media-buffers) - [Classical Media & Buffers](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/cell-culture-media-and-buffers/classical-media-and-buffers) - [Custom GMP Cell Culture Media](https://www.sigmaaldrich.com/US/en/services/custom-products/custom-gmp-cell-culture-products) - [Plant Culture Media](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/cell-culture-media-and-buffers/plant-culture-media) - [Cell Culture Supplements & Reagents](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/cell-culture-supplements-and-reagents) - [Albumins & Transport Proteins](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/cell-culture-supplements-and-reagents/albumins-and-transport-proteins) - [Amino Acids](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/biochemicals/amino-acids) - [Antibiotics](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/biochemicals/antibiotics) - [Attachment Factors](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/cell-culture-supplements-and-reagents/attachment-factors) - [Bioprocessing Recombinant Supplements](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/bioprocessing-cell-culture/recombinant-supplements) - [Carbohydrates](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/biochemicals/carbohydrates) - [Cell Dissociation Reagents](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/cell-culture-supplements-and-reagents/cell-dissociation-reagents) - [Cell Freezing Reagents](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/cell-culture-supplements-and-reagents/cell-freezing-reagents) - [FBS](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/cell-culture-supplements-and-reagents/fbs) - [Growth Factors & Cytokines](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/cell-culture-supplements-and-reagents/growth-factors-and-cytokines) - [Hormones](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/cell-culture-supplements-and-reagents/hormones) - [Human Serum](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/cell-culture-supplements-and-reagents/human-serum) - [(Other) Sera](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/cell-culture-supplements-and-reagents/other-sera) - [Plant Culture Reagents](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/cell-culture-supplements-and-reagents/plant-culture-reagents) - [Sera](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/cell-culture-supplements-and-reagents/sera) - [Supplements for Cell Culture](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/cell-culture-supplements-and-reagents/supplements) - [Vitamins](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/biochemicals/vitamins) - [Cell Lines & Specialty Cell Culture](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/cell-lines-and-specialty-cell-culture) - [Bioprocessing Cell Lines](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/bioprocessing-cell-culture/bioprocessing-cell-lines) - [Mammalian Cell Lines](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/cell-lines-and-specialty-cell-culture/mammalian-cell-lines) - [Mouse Embryo Media](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/cell-lines-and-specialty-cell-culture/mouse-embryo-media) - [Primary Cells](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/cell-lines-and-specialty-cell-culture/primary-cells) - [Stem Cells](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/cell-lines-and-specialty-cell-culture/stem-cells) - [Sterile Lab Media Filtration & Cultureware](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/sterile-lab-media-filtration-and-cultureware) - [Cell Culture Supplies](https://www.sigmaaldrich.com/US/en/products/labware/cell-culture-and-cryogenics/cell-culture-supplies) - [Millex^® Syringe Filters](https://www.sigmaaldrich.com/US/en/products/filtration/laboratory-syringe-filters/millex-syringe-filters) - [Millicell^® Cell Culture Inserts & Plates](https://www.sigmaaldrich.com/US/en/products/labware/cell-culture-and-cryogenics/millicell-cell-culture-inserts-and-plates) - [Millipore^® Sterile Filters](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/sterile-lab-media-filtration-and-cultureware/millipore-sterile-filters) - [MultiScreen^® Filter Plates](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/sterile-lab-media-filtration-and-cultureware/multiscreen-filter-plates) - [Stericup^® Vacuum Filters](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/sterile-lab-media-filtration-and-cultureware/stericup-vacuum-filtration) - [Chemistry & Biochemicals](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals) - [Amino Acids, Resins & Reagents for Peptide Synthesis](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/amino-acids-resins-and-reagents-for-peptide-synthesis) - [Biochemicals](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/biochemicals) - [Agarose](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/biochemicals/agarose) - [Amino Acids](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/biochemicals/amino-acids) - [Antibiotics](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/biochemicals/antibiotics) - [Avanti Research™, A Croda Brand](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/biochemicals/avanti-research) - [Biological Buffers](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/biochemicals/biological-buffers) - [Carbohydrates](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/biochemicals/carbohydrates) - [Chelating & Reducing Agents](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/biochemicals/chelating-reducing-agents) - [Coenzymes](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/biochemicals/coenzymes) - [Detergents](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/biochemicals/detergents) - [Lipids](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/biochemicals/lipids) - [Glycoconjugates](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/biochemicals/glycoconjugates) - [High-Purity Biochemicals & Reagents](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/biochemicals/high-purity-biochemicals-and-reagents) - [Metabolism Assay Kits](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/biochemicals/metabolism-assay-kits) - [Metabolite Libraries](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/biochemicals/metabolite-libraries) - [Natural Products](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/biochemicals/natural-products) - [Nucleosides & Nucleotides](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/biochemicals/nucleosides-and-nucleotides) - [Vitamins](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/biochemicals/vitamins) - [Building Blocks](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/building-blocks) - [Fluorinated Building Blocks](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/building-blocks/fluorinated-building-blocks) - [Halogenated Heterocycles](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/building-blocks/halogenated-heterocycles) - [Heterocyclic Building Blocks](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/building-blocks/heterocyclic-building-blocks) - [Organic Building Blocks](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/building-blocks/organic-building-blocks) - [Catalysts](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/catalysts) - [Buchwald Catalysts & Ligands](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/catalysts/buchwald-catalysts-and-ligands) - [C-H Activation Catalysts](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/catalysts/c-h-activation-catalysts) - [Chiral Catalysts & Ligands](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/catalysts/chiral-catalysts-and-ligands) - [Cross-Coupling Catalysts](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/catalysts/cross-coupling-catalysts) - [Hydrogenation Catalysts](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/catalysts/hydrogenation-catalysts) - [Inorganic Catalysts](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/catalysts/inorganic-catalysts) - [NHC Ligands & Complexes](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/catalysts/nhc-ligands-and-complexes) - [Olefin Metathesis](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/catalysts/olefin-metathesis) - [Organocatalysts](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/catalysts/organocatalysts) - [Phase-Transfer Catalysts](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/catalysts/phase-transfer-catalysts) - [Phosphine Ligands](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/catalysts/phosphine-ligands) - [Photocatalysts](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/catalysts/photocatalysts) - [Transition Metal Catalysts](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/catalysts/transition-metal-catalysts) - [Chemical Biology](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/chemical-biology) - [Carbohydrates](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/biochemicals/carbohydrates) - [Chemical Biology Tools](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/chemical-biology/chemical-biology-tools) - [Click Chemistry Reagents](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/chemical-biology/click-chemistry-reagents) - [Crosslinkers](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/chemical-biology/crosslinkers) - [Protein Degrader Building Blocks](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/chemical-biology/protein-degrader-building-blocks) - [Chemical Synthesis](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/chemical-synthesis) - [Boronic Acids & Derivatives](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/chemical-synthesis/boronic-acids-and-derivatives) - [C-C Bond Forming Reagents](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/chemical-synthesis/c-c-bond-forming-reagents) - [Chiral Auxiliaries](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/chemical-synthesis/chiral-auxiliaries) - [Coupling Reagents & Nucleosides](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/chemical-synthesis/coupling-reagents-and-nucleosides) - [Grignard Reagents](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/chemical-synthesis/grignard-reagents) - [Halogenation Reagents](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/chemical-synthesis/halogenation-reagents) - [Organoaluminum Reagents](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/chemical-synthesis/organoaluminum-reagents) - [Organolithium Reagents](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/chemical-synthesis/organolithium-reagents) - [Organosilicon Reagents](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/chemical-synthesis/organosilicon-reagents) - [Organotin Reagents](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/chemical-synthesis/organotin-reagents) - [Organozinc Reagents](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/chemical-synthesis/organozinc-reagents) - [Oxidation Reagents](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/chemical-synthesis/oxidation-reagents) - [Protection/Deprotection Reagents](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/chemical-synthesis/protection-deprotection-reagents) - [Reducing Agents](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/chemical-synthesis/reducing-agents) - [Flavors & Fragrances](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/flavors-and-fragrances) - [Formulation](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/formulation) - [Biomolecule Formulation](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/formulation/biomolecule-formulation) - [Granulated Materials](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/formulation/granulated-materials) - [Liquid Formulation](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/formulation/liquid-formulation) - [Protein Stabilizers](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/formulation/protein-stabilizers) - [Semisolid Formulation](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/formulation/semisolid-formulation) - [Solid Formulation](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/formulation/solid-formulation) - [Lab Chemicals](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/lab-chemicals) - [Absorbents & Adsorbents](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/lab-chemicals/absorbents-and-adsorbents) - [Acids](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/lab-chemicals/acids) - [Caustic Alkalis & Bases](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/lab-chemicals/caustic-alkalis-and-bases) - [Drying Agents](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/lab-chemicals/drying-agents) - [Filter Aids & Filter Media](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/lab-chemicals/filter-aids-filter-media) - [Indicators](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/analytical-reagents/indicators) - [Metals](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/lab-chemicals/metals) - [Salts](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/lab-chemicals/salts) - [Solvents](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/analytical-chromatography/solvents) - [Lab Safety](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/lab-safety) - [Labware Detergents & Cleaners](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/lab-safety/cleaning-detergents) - [Safe Handling](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/lab-safety/safe-handling) - [Safety Accessories](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/lab-safety/safety-accessories) - [Spillage Absorption](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/lab-safety/spillage-absorption) - [Stable Isotopes](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/stable-isotopes) - [Synthesis Enabling Tools](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/synthesis-enabling-tools) - [Automated Chemical Synthesis](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/synthesis-enabling-tools/automated-chemical-synthesis) - [High Throughput Screening](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/synthesis-enabling-tools/high-throughput-screening-platform) - [Photoreactors](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/synthesis-enabling-tools/photoreactors) - [Electrosynthesis](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/synthesis-enabling-tools/electrosynthesis-platform) - [Clinical & Diagnostics](https://www.sigmaaldrich.com/US/en/products/clinical-diagnostics) - [Blood Typing](https://www.sigmaaldrich.com/US/en/products/clinical-diagnostics/blood-typing) - [Blood Typing Finished Reagents](https://www.sigmaaldrich.com/US/en/products/clinical-diagnostics/blood-typing/blood-typing-finished-reagents) - [Blood Typing Intermediates For Further Manufacturing Use (FFMU)](https://www.sigmaaldrich.com/US/en/products/clinical-diagnostics/blood-typing/blood-typing-intermediates) - [Cell Marque™](https://www.sigmaaldrich.com/US/en/products/clinical-diagnostics/cell-marque) - [Cell Marque™ Control Slides](https://www.sigmaaldrich.com/US/en/products/clinical-diagnostics/cell-marque/cell-marque-control-slides) - [Cell Marque™ Detection Systems & Ancillary Reagents](https://www.sigmaaldrich.com/US/en/products/clinical-diagnostics/cell-marque/cell-marque-detection-systems-and-ancillary-reagents) - [Cell Marque™ Primary Antibodies](https://www.sigmaaldrich.com/US/en/products/clinical-diagnostics/cell-marque/cell-marque-ihc-antibodies) - [Lateral Flow Membranes](https://www.sigmaaldrich.com/US/en/products/clinical-diagnostics/lateral-flow-membranes) - [ProClin™ Preservatives](https://www.sigmaaldrich.com/US/en/products/clinical-diagnostics/proclin-preservatives) - [Tissue Diagnostics](https://www.sigmaaldrich.com/US/en/products/clinical-diagnostics/tissue-diagnostics) - [Bacteriology Stains](https://www.sigmaaldrich.com/US/en/products/clinical-diagnostics/tissue-diagnostics/bacteriology-stains) - [Cell Separation Media](https://www.sigmaaldrich.com/US/en/products/clinical-diagnostics/tissue-diagnostics/cell-separation-media) - [Cytology Stains](https://www.sigmaaldrich.com/US/en/products/clinical-diagnostics/tissue-diagnostics/cytology-stains) - [Dry Dyes & Certified Stains](https://www.sigmaaldrich.com/US/en/products/clinical-diagnostics/tissue-diagnostics/dry-dyes-and-certified-stains) - [FISH Probes & Reagents](https://www.sigmaaldrich.com/US/en/products/clinical-diagnostics/tissue-diagnostics/zytovision-in-situ-hybridization-probes) - [Hematology Stains](https://www.sigmaaldrich.com/US/en/products/clinical-diagnostics/tissue-diagnostics/hematology-stains) - [Histology Stains](https://www.sigmaaldrich.com/US/en/products/clinical-diagnostics/tissue-diagnostics/histology-stains) - [Tissue Diagnostics Universal Reagents](https://www.sigmaaldrich.com/US/en/products/clinical-diagnostics/tissue-diagnostics/tissue-diagnostics-universal-reagents) - [Filtration](https://www.sigmaaldrich.com/US/en/products/filtration) - [Concentration Filters](https://www.sigmaaldrich.com/US/en/products/filtration/concentration-filters) - [Amicon^® Centrifugals](https://www.sigmaaldrich.com/US/en/products/protein-biology/protein-sample-prep/amicon-centrifugals) - [Centrifugal Filters](https://www.sigmaaldrich.com/US/en/products/filtration/concentration-filters/centrifugal-filters) - [Filter Paper](https://www.sigmaaldrich.com/US/en/products/filtration/filter-paper) - [Filtration for Bioprocessing](https://www.sigmaaldrich.com/US/en/products/filtration/filtration-for-bioprocessing) - [Buffer Filtration](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/buffer-media-prep/buffer-filtration) - [Clarification Filter Holders & Systems](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/clarification-harvest/clarification-filter-holders-and-systems-for-bioprocessing) - [Filter Housings](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/sterile-filtration-and-bioburden-control/filter-housings) - [Final Sterile Filtration & Filling](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/sterile-filtration-and-bioburden-control/final-sterile-filtration-and-filling) - [Gas & Vent Filters](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/sterile-filtration-and-bioburden-control/gas-and-vent-filters) - [Integrity Testers](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/sterile-filtration-and-bioburden-control/integrity-testers) - [Media Filtration](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/buffer-media-prep/media-filtration) - [Prefilters & Bioburden Control](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/sterile-filtration-and-bioburden-control/prefilters-and-bioburden-control) - [Sterile Filters](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/sterile-filtration-and-bioburden-control/sterile-filters) - [Virus Filter Holders & Systems](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/viral-clearance/virus-filter-holders-and-systems) - [Virus Filters](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/viral-clearance/virus-filters) - [Laboratory Filter Holders](https://www.sigmaaldrich.com/US/en/products/filtration/laboratory-filter-holders) - [Laboratory Filter Membranes](https://www.sigmaaldrich.com/US/en/products/filtration/laboratory-filter-membranes) - [Filter Membranes](https://www.sigmaaldrich.com/US/en/products/filtration/laboratory-filter-membranes/filter-membranes) - [Millipore^® Filter Membranes](https://www.sigmaaldrich.com/US/en/products/filtration/laboratory-filter-membranes/millipore-filter-membranes) - [Laboratory Syringe Filters](https://www.sigmaaldrich.com/US/en/products/filtration/laboratory-syringe-filters) - [Syringe Filters](https://www.sigmaaldrich.com/US/en/products/filtration/laboratory-syringe-filters/syringe-filters) - [Millex^® Syringe Filters](https://www.sigmaaldrich.com/US/en/products/filtration/laboratory-syringe-filters/millex-syringe-filters) - [MultiScreen^® Filter Plates](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/sterile-lab-media-filtration-and-cultureware/multiscreen-filter-plates) - [Sterile Laboratory Filter Devices](https://www.sigmaaldrich.com/US/en/products/filtration/sterile-laboratory-filter-devices) - [Millipore^® Sterile Filters](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/sterile-lab-media-filtration-and-cultureware/millipore-sterile-filters) - [Stericup^® Vacuum Filters](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/sterile-lab-media-filtration-and-cultureware/stericup-vacuum-filtration) - [Vacuum Filters](https://www.sigmaaldrich.com/US/en/products/filtration/vacuum-filters) - [Greener Alternative Products](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/greener-alternative-products) - [Industrial Microbiology](https://www.sigmaaldrich.com/US/en/products/industrial-microbiology) - [Environmental Monitoring & Aseptic Process Simulation](https://www.sigmaaldrich.com/US/en/products/industrial-microbiology/viable-air-samplers) - [Hygiene Monitoring](https://www.sigmaaldrich.com/US/en/products/industrial-microbiology/hygiene-monitoring-instruments-samplers-tests-and-accessories) - [Microbial Culture Media](https://www.sigmaaldrich.com/US/en/products/industrial-microbiology/microbial-culture-media) - [Microbial Culture Media Raw Materials](https://www.sigmaaldrich.com/US/en/products/industrial-microbiology/microbial-culture-media-raw-materials) - [Microbial Filtration](https://www.sigmaaldrich.com/US/en/products/industrial-microbiology/microbial-filtration) - [Microbial Identification Tests & Biochemical Reagents](https://www.sigmaaldrich.com/US/en/products/industrial-microbiology/microbial-identification-tests) - [Microbiology Standards](https://www.sigmaaldrich.com/US/en/products/analytical-chemistry/reference-materials/microbiology-standards) - [Pathogen Screening Kits, Instruments, Disposables](https://www.sigmaaldrich.com/US/en/products/industrial-microbiology/pathogen-screening-kits-instuments-and-disposables) - [Pyrogen Testing](https://www.sigmaaldrich.com/US/en/products/industrial-microbiology/pyrogen-testing) - [Quality Indicator Testing Devices](https://www.sigmaaldrich.com/US/en/products/industrial-microbiology/quality-indicator-testing-devices) - [Sterility Testing Consumables, Media & Instruments](https://www.sigmaaldrich.com/US/en/products/industrial-microbiology/sterility-testing-consumables-media-and-filtration) - [Lab Automation](https://www.sigmaaldrich.com/US/en/products/lab-automation) - [AAW™ Automated Assay Workstation](https://www.sigmaaldrich.com/US/en/products/lab-automation/aaw-automated-assay-workstation) - [Labware](https://www.sigmaaldrich.com/US/en/products/labware) - [Cell Culture & Cryogenics](https://www.sigmaaldrich.com/US/en/products/labware/cell-culture-and-cryogenics) - [Cell Culture Supplies](https://www.sigmaaldrich.com/US/en/products/labware/cell-culture-and-cryogenics/cell-culture-supplies) - [Cryo Storage](https://www.sigmaaldrich.com/US/en/products/labware/cryo-storage) - [Millicell^® Cell Culture Inserts & Plates](https://www.sigmaaldrich.com/US/en/products/labware/cell-culture-and-cryogenics/millicell-cell-culture-inserts-and-plates) - [Filtration](https://www.sigmaaldrich.com/US/en/products/labware/filtration) - [Centrifugal Filters](https://www.sigmaaldrich.com/US/en/products/filtration/concentration-filters/centrifugal-filters) - [Filter Membranes](https://www.sigmaaldrich.com/US/en/products/filtration/laboratory-filter-membranes/filter-membranes) - [Filter Paper](https://www.sigmaaldrich.com/US/en/products/filtration/filter-paper) - [Laboratory Filter Holders](https://www.sigmaaldrich.com/US/en/products/filtration/laboratory-filter-holders) - [Syringe Filters](https://www.sigmaaldrich.com/US/en/products/filtration/laboratory-syringe-filters/syringe-filters) - [Vacuum Filters](https://www.sigmaaldrich.com/US/en/products/filtration/vacuum-filters) - [Amicon^® Centrifugals](https://www.sigmaaldrich.com/US/en/products/protein-biology/protein-sample-prep/amicon-centrifugals) - [Millex^® Syringe Filters](https://www.sigmaaldrich.com/US/en/products/filtration/laboratory-syringe-filters/millex-syringe-filters) - [Millipore^® Filter Membranes](https://www.sigmaaldrich.com/US/en/products/filtration/laboratory-filter-membranes/millipore-filter-membranes) - [Millipore^® Sterile Filters](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/sterile-lab-media-filtration-and-cultureware/millipore-sterile-filters) - [MultiScreen^® Filter Plates](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/sterile-lab-media-filtration-and-cultureware/multiscreen-filter-plates) - [Stericup^® Vacuum Filters](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/sterile-lab-media-filtration-and-cultureware/stericup-vacuum-filtration) - [Glassware](https://www.sigmaaldrich.com/US/en/products/labware/glassware) - [Lab Equipment](https://www.sigmaaldrich.com/US/en/products/labware/laboratory-equipment) - [Balances](https://www.sigmaaldrich.com/US/en/products/labware/laboratory-equipment/laboratory-balances) - [Centrifugation](https://www.sigmaaldrich.com/US/en/products/labware/laboratory-equipment/laboratory-centrifugation) - [Grinders & Homogenizers](https://www.sigmaaldrich.com/US/en/products/labware/sample-handling/grinders-and-homogenizers) - [Laboratory Stirring & Mixing](https://www.sigmaaldrich.com/US/en/products/labware/sample-handling/laboratory-stirring-and-mixing) - [Refrigerators & Freezers](https://www.sigmaaldrich.com/US/en/products/labware/laboratory-equipment/refrigerators-freezers) - [Water Purification](https://www.sigmaaldrich.com/US/en/products/water-purification) - [Labware Partners](https://www.sigmaaldrich.com/US/en/products/labware/labware-partners) - [Benchmark Scientific Products](https://www.sigmaaldrich.com/US/en/products/labware/labware-partners/benchmark-scientific) - [Brand^® Products](https://www.sigmaaldrich.com/US/en/products/labware/labware-partners/brand) - [Corning^® Products](https://www.sigmaaldrich.com/US/en/products/labware/labware-partners/corning) - [Cytiva™ Products](https://www.sigmaaldrich.com/US/en/products/labware/labware-partners/cytiva) - [DWK Products](https://www.sigmaaldrich.com/US/en/products/labware/glassware/dwk) - [Eppendorf^® Products](https://www.sigmaaldrich.com/US/en/products/labware/labware-partners/eppendorf) - [Excel Scientific Products](https://www.sigmaaldrich.com/US/en/products/labware/labware-partners/excel-scientific) - [Heathrow Scientific^® Products](https://www.sigmaaldrich.com/US/en/products/labware/labware-partners/heathrow-scientific) - [LGC Biosearch™ Products](https://www.sigmaaldrich.com/US/en/products/labware/labware-partners/lgc-biosearch) - [OHAUS^® Products](https://www.sigmaaldrich.com/US/en/products/labware/labware-partners/ohaus) - [Pop-Bio Products](https://www.sigmaaldrich.com/US/en/products/labware/labware-partners/pop-bio) - [Roche^® Products](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/roche-life-science-products) - [Liquid Handling & Dispensing](https://www.sigmaaldrich.com/US/en/products/labware/liquid-handling-and-dispensing) - [Microscope Slides & Chambers](https://www.sigmaaldrich.com/US/en/products/labware/microscope-slides-and-chambers) - [PCR Supplies & Equipment](https://www.sigmaaldrich.com/US/en/products/labware/pcr-supplies-and-equipment) - [Plates](https://www.sigmaaldrich.com/US/en/products/labware/plates) - [Millicell^® Cell Culture Inserts & Plates](https://www.sigmaaldrich.com/US/en/products/labware/cell-culture-and-cryogenics/millicell-cell-culture-inserts-and-plates) - [MultiScreen^® Filter Plates](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/sterile-lab-media-filtration-and-cultureware/multiscreen-filter-plates) - [MultiScreen^® Solid Bottom Plates](https://www.sigmaaldrich.com/US/en/products/labware/plates/multiscreen-solid-bottom-plates) - [Sample Handling](https://www.sigmaaldrich.com/US/en/products/labware/sample-handling) - [Grinders & Homogenizers](https://www.sigmaaldrich.com/US/en/products/labware/sample-handling/grinders-and-homogenizers) - [Laboratory Containers & Storage](https://www.sigmaaldrich.com/US/en/products/labware/sample-handling/laboratory-containers-and-storage) - [Laboratory Labels](https://www.sigmaaldrich.com/US/en/products/labware/sample-handling/laboratory-labels) - [Laboratory Sample Collection](https://www.sigmaaldrich.com/US/en/products/labware/sample-handling/laboratory-sample-collection) - [Laboratory Stirring & Mixing](https://www.sigmaaldrich.com/US/en/products/labware/sample-handling/laboratory-stirring-and-mixing) - [Sealing Films, Foils, Tapes](https://www.sigmaaldrich.com/US/en/products/labware/sealing-films-foils-and-tapes) - [Septa](https://www.sigmaaldrich.com/US/en/products/labware/septa) - [Materials Science](https://www.sigmaaldrich.com/US/en/products/materials-science) - [Biomedical Materials](https://www.sigmaaldrich.com/US/en/products/materials-science/biomedical-materials) - [3D Bioprinting](https://www.sigmaaldrich.com/US/en/products/materials-science/biomedical-materials/3d-bioprinting) - [Biomedical Polymers](https://www.sigmaaldrich.com/US/en/products/materials-science/biomedical-materials/biomedical-polymers) - [Drug Delivery Formulation Kits](https://www.sigmaaldrich.com/US/en/products/materials-science/biomedical-materials/drug-delivery-formulation-kits) - [Hydrophilic Polymers](https://www.sigmaaldrich.com/US/en/products/materials-science/biomedical-materials/hydrophilic-polymers) - [Hydrophobic Polymers](https://www.sigmaaldrich.com/US/en/products/materials-science/biomedical-materials/hydrophobic-polymers) - [Polyethylene Glycol (PEGs & PEOs)](https://www.sigmaaldrich.com/US/en/products/materials-science/biomedical-materials/polyethylene-glycol) - [Polymeric Microspheres & Nanoparticles](https://www.sigmaaldrich.com/US/en/products/materials-science/biomedical-materials/polymeric-microspheres-and-nanoparticles) - [Polymerization Tools](https://www.sigmaaldrich.com/US/en/products/materials-science/biomedical-materials/polymerization-tools) - [Electronic Materials](https://www.sigmaaldrich.com/US/en/products/materials-science/electronic-materials) - [Carbon Nanomaterials](https://www.sigmaaldrich.com/US/en/products/materials-science/electronic-materials/carbon-nanomaterials) - [Electronic Chemicals & Etchants](https://www.sigmaaldrich.com/US/en/products/materials-science/electronic-materials/electronic-chemicals-and-etchants) - [Inorganic & Metallic Nanomaterials](https://www.sigmaaldrich.com/US/en/products/materials-science/electronic-materials/inorganic-and-metallic-nanomaterials) - [Liquid Crystals](https://www.sigmaaldrich.com/US/en/products/materials-science/electronic-materials/liquid-crystals) - [OLED & PLED Materials](https://www.sigmaaldrich.com/US/en/products/materials-science/electronic-materials/oled-and-pled-materials) - [OFET & OPV Materials](https://www.sigmaaldrich.com/US/en/products/materials-science/electronic-materials/ofet-and-opv-materials) - [Photonic & Optical Materials](https://www.sigmaaldrich.com/US/en/products/materials-science/electronic-materials/photonic-and-optical-materials) - [Printed Electronic Materials](https://www.sigmaaldrich.com/US/en/products/materials-science/electronic-materials/printed-electronic-materials) - [Self-assembly & Contact Printing](https://www.sigmaaldrich.com/US/en/products/materials-science/electronic-materials/self-assembly-and-contact-printing) - [Silicone Materials](https://www.sigmaaldrich.com/US/en/products/materials-science/electronic-materials/silicone-materials) - [Specialty & Smart Polymers](https://www.sigmaaldrich.com/US/en/products/materials-science/electronic-materials/specialty-and-smart-polymers) - [Substrates & Prefab Electronic Components](https://www.sigmaaldrich.com/US/en/products/materials-science/electronic-materials/substrates-and-prefab-electronic-components) - [Energy Materials](https://www.sigmaaldrich.com/US/en/products/materials-science/energy-materials) - [Battery Materials](https://www.sigmaaldrich.com/US/en/products/materials-science/energy-materials/battery-materials) - [Chalcogenides](https://www.sigmaaldrich.com/US/en/products/materials-science/energy-materials/chalcogenides) - [Fuel Cell Membranes & Materials](https://www.sigmaaldrich.com/US/en/products/materials-science/energy-materials/fuel-cell-membranes-and-materials) - [High-Purity Metals & Alloys](https://www.sigmaaldrich.com/US/en/products/materials-science/energy-materials/high-purity-metals-and-alloys) - [High-Purity Salts](https://www.sigmaaldrich.com/US/en/products/materials-science/energy-materials/high-purity-salts) - [Oxides & Ceramics](https://www.sigmaaldrich.com/US/en/products/materials-science/energy-materials/oxides-and-ceramics) - [Quantum Dots](https://www.sigmaaldrich.com/US/en/products/materials-science/energy-materials/quantum-dots) - [Solar Energy Materials](https://www.sigmaaldrich.com/US/en/products/materials-science/energy-materials/solar-energy-materials) - [Solution & Vapor Deposition Precursors](https://www.sigmaaldrich.com/US/en/products/materials-science/energy-materials/solution-and-vapor-deposition-precursors) - [Molecular Biology & Functional Genomics](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics) - [Cloning & Expression](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/cloning-and-expression) - [Molecular Cloning & Protein Expression](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/cloning-and-expression/molecular-cloning-and-protein-expression) - [Transfection](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/cloning-and-expression/transfection) - [Epigenetics](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/epigenetics) - [Gene Editing & Functional Genomics](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/gene-editing-and-functional-genomics) - [CRISPR & Gene Editing](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/gene-editing-and-functional-genomics/crispr-gene-editing) - [Genetic Screening](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/gene-editing-and-functional-genomics/genetic-screening) - [RNAi Libraries](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/gene-editing-and-functional-genomics/rnai-libraries) - [RNAi Single Clones](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/gene-editing-and-functional-genomics/rnai-single-clones) - [<i>In situ</i> Hybridization Probes & Reagents](https://www.sigmaaldrich.com/US/en/products/clinical-diagnostics/tissue-diagnostics/zytovision-in-situ-hybridization-probes) - [Microbiome](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/microbiome) - [NGS Library Preparation](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/ngs-library-prep) - [Nucleic Acid Electrophoresis & Hybridization](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/nucleic-acid-electrophoresis-and-hybridization) - [Nucleic Acid Electrophoresis, Transfer & Quantitation](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/nucleic-acid-electrophoresis-and-hybridization/nucleic-acid-electrophoresis-transfer-and-quantitation) - [Nucleic Acid Labeling](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/nucleic-acid-electrophoresis-and-hybridization/nucleic-acid-labeling) - [Nucleic Acid Purification](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/nucleic-acid-purification) - [gDNA Purification](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/nucleic-acid-purification/gdna-purification) - [Plasmid DNA Purification](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/nucleic-acid-purification/plasmid-dna-purification) - [Reaction Clean-Up](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/nucleic-acid-purification/reaction-clean-up) - [RNA Purification](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/nucleic-acid-purification/rna-purification) - [Oligos, qPCR Probes & Peptides](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/oligos-and-qpcr-probes) - [Custom & Predesigned DNA Oligos and qPCR Probes](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/oligos-and-qpcr-probes/custom-predesigned-dna-oligos-and-qpcr-probes) - [Custom & Predesigned RNA Oligos, siRNA Duplexes and Controls](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/oligos-and-qpcr-probes/custom-predesigned-rna-oligos-sirna-duplexes-controls) - [Custom Peptides](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/oligos-and-qpcr-probes/custom-peptides) - [PCR & Amplification](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/pcr-and-amplification) - [Kapa Biosystems PCR Reagents](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/pcr-and-amplification/kapa-biosystems-pcr-reagents) - [PCR Reagent & Kits](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/pcr-and-amplification/pcr-reagents-and-kits) - [PCR Supplies & Equipment](https://www.sigmaaldrich.com/US/en/products/labware/pcr-supplies-and-equipment) - [Whole Genome Amplification](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/pcr-and-amplification/whole-genome-amplification) - [Roche^® Life Science Products](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/roche-life-science-products) - [mAbs Development & Manufacturing](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies) - [Antibody Drug Discovery](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies/antibody-drug-discovery) - [Lead Selection & Optimization](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies/antibody-drug-discovery/lead-discovery) - [Preclinical Development](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies/antibody-drug-discovery/preclinical-development) - [Target Discovery](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies/antibody-drug-discovery/target-discovery) - [Characterization & Quality Control](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies/characterization-and-quality-control) - [Aggregate Analysis](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies/characterization-and-quality-control/aggregate-analysis) - [Intact Mass Analysis](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies/characterization-and-quality-control/intact-mass-analysis) - [Peptide Mapping](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies/characterization-and-quality-control/peptide-mapping) - [Post-Translational Modification](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies/characterization-and-quality-control/post-translational-modification-analysis) - [Titer Determination](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies/characterization-and-quality-control/titer-determination) - [Process Development, Manufacturing, Formulation & Final Fill](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies/process-development-manufacturing) - [Downstream Processing (DSP)](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies/process-development-manufacturing/downstream-processing-mabs) - [Formulation & Final Fill](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies/process-development-manufacturing/formulation-final-fill-mabs) - [Upstream Processing (USP)](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies/process-development-manufacturing/upstream-processing-mabs) - [mRNA Development & Manufacturing](https://www.sigmaaldrich.com/US/en/integrated-offerings/mrna-development-manufacturing) - [mRNA Analytical & Quality Control](https://www.sigmaaldrich.com/US/en/integrated-offerings/mrna-development-manufacturing/mrna-analytical-quality-control) - [mRNA Development](https://www.sigmaaldrich.com/US/en/integrated-offerings/mrna-development-manufacturing/mrna-development) - [mRNA Manufacturing & Formulation](https://www.sigmaaldrich.com/US/en/integrated-offerings/mrna-development-manufacturing/mrna-manufacturing-formulation) - [mRNA Research](https://www.sigmaaldrich.com/US/en/integrated-offerings/mrna-development-manufacturing/mrna-research) - [Pharma & Biopharma Manufacturing](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing) - [Active Pharmaceutical Ingredients](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/active-pharmaceutical-ingredients) - [API Processing Chemicals](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/active-pharmaceutical-ingredients/api-processing-chemicals) - [Folates](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/active-pharmaceutical-ingredients/folates) - [Portfolio APIs](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/active-pharmaceutical-ingredients/portfolio-apis) - [Bioprocessing & Formulation Raw Materials](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/bioprocessing-formulation-raw-materials) - [Bioprocessing Liquid Cell Culture Media & Buffers](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/bioprocessing-formulation-raw-materials/liquid-cell-culture-media-buffers) - [Buffers & pH Adjusters](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/buffer-media-prep/buffers-and-ph-adjusters) - [Cleaning in Place](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/bioprocessing-formulation-raw-materials/cleaning-in-place) - [Detergents for Biopharma Applications](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/bioprocessing-formulation-raw-materials/detergents) - [Downstream Process & Formulation Chemicals](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/bioprocessing-formulation-raw-materials/downstream-process-formulation-chemicals) - [Endonuclease](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/bioprocessing-formulation-raw-materials/endonuclease) - [High-Quality Chemicals for mRNA Manufacturing](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/bioprocessing-formulation-raw-materials/high-quality-chemicals-for-mrna-manufacturing) - [Upstream Process Chemicals](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/bioprocessing-formulation-raw-materials/upstream-process-chemicals) - [Bioprocessing Cell Culture](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/bioprocessing-cell-culture) - [Bioprocessing Cell Culture Media](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/bioprocessing-cell-culture/bioprocessing-cell-culture-media) - [Bioprocessing Cell Lines](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/bioprocessing-cell-culture/bioprocessing-cell-lines) - [Bioprocessing Liquid Cell Culture Media & Buffers](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/bioprocessing-formulation-raw-materials/liquid-cell-culture-media-buffers) - [Bioprocessing Recombinant Supplements](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/bioprocessing-cell-culture/recombinant-supplements) - [Bulk Powder Transfer Bags](https://www.sigmaaldrich.com/US/en/services/custom-products/bulk-powder-transfer-bags) - [Cell Retention](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/bioprocessing-cell-culture/cell-retention) - [Custom GMP Cell Culture Media](https://www.sigmaaldrich.com/US/en/services/custom-products/custom-gmp-cell-culture-products) - [Media Filtration](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/buffer-media-prep/media-filtration) - [Viral Vector Upstream Platforms](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/bioprocessing-cell-culture/viral-vector-upstream-platforms) - [Bioprocessing Systems](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/bioprocessing-systems) - [Chromatography Columns for Bioprocessing](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/chromatography-bioprocessing/chromatography-columns) - [Chromatography Systems](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/chromatography-bioprocessing/chromatography-systems) - [Clarification Filter Holders & Systems](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/clarification-harvest/clarification-filter-holders-and-systems-for-bioprocessing) - [Integrity Testers](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/sterile-filtration-and-bioburden-control/integrity-testers) - [Single-Use Mixers](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/buffer-media-prep/single-use-mixers) - [Stainless Steel Connectors, Valves & Mixers](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/fluid-management/stainless-steel-connectors-valves-mixers) - [Tangential Flow Filtration Holders & Systems](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/ultrafiltration-diafiltration/tangential-flow-holders-systems) - [Virus Filter Holders & Systems](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/viral-clearance/virus-filter-holders-and-systems) - [Buffer & Media Prep](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/buffer-media-prep) - [Buffers & pH Adjusters](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/buffer-media-prep/buffers-and-ph-adjusters) - [Buffer Filtration](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/buffer-media-prep/buffer-filtration) - [Media Filtration](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/buffer-media-prep/media-filtration) - [Single-Use Mixers](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/buffer-media-prep/single-use-mixers) - [Chromatography](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/chromatography-bioprocessing) - [Affinity Chromatography Resins](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/chromatography-bioprocessing/affinity-resins) - [Chromatography Columns for Bioprocessing](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/chromatography-bioprocessing/chromatography-columns) - [Chromatography Systems](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/chromatography-bioprocessing/chromatography-systems) - [Ion Exchange Chromatography Resins](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/chromatography-bioprocessing/ion-exchange-chromatography) - [Membrane Chromatography](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/chromatography-bioprocessing/membrane-chromatography) - [Reverse Phase/Normal Phase Chromatography Resins](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/chromatography-bioprocessing/reverse-normal-phase-chromatography) - [Size Exclusion Chromatography Resins](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/chromatography-bioprocessing/size-exclusion-chromatography) - [Clarification & Harvest](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/clarification-harvest) - [Clarification Depth Filters & Pretreatment Solutions](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/clarification-harvest/clarification-depth-filters-pretreatment-solutions) - [Clarification Filter Holders & Systems](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/clarification-harvest/clarification-filter-holders-and-systems-for-bioprocessing) - [Clarification Prefilters](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/clarification-harvest/clarification-prefilters) - [Fluid Management](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/fluid-management) - [Connection/Disconnection for Bioprocessing](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/fluid-management/connection-disconnection-for-bioprocessing) - [Fluid Transport & Storage](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/fluid-management/fluid-transport-and-storage) - [Single-Use Assemblies](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/fluid-management/single-use-assemblies) - [Single-Use Mixers](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/buffer-media-prep/single-use-mixers) - [Stainless Steel Connectors, Valves & Mixers](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/fluid-management/stainless-steel-connectors-valves-mixers) - [Formulation](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/formulation) - [Activated & Functionalized PEGs](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/formulation/activated-functionalized-pegs) - [Biomolecule Formulation](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/formulation/biomolecule-formulation) - [Granulated Materials](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/formulation/granulated-materials) - [Injectables & Parenteral Formulations](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/formulation/injectables-parenteral-formulations) - [Liquid Formulation](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/formulation/liquid-formulation) - [Protein Stabilizers](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/formulation/protein-stabilizers) - [Semisolid Formulation](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/formulation/semisolid-formulation) - [Solid Formulation](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/formulation/solid-formulation) - [Synthetic Lipids](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/formulation/synthetic-lipids) - [Viscosity Reduction Platform](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/formulation/viscosity-reduction-platform) - [Sterile & Aseptic Sampling Solutions](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/sterile-and-aseptic-sampling) - [Sterile Process Sampling](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/sterile-and-aseptic-sampling/manual-sterile-sampling) - [Sampling with MAST^® Autosampling Solution](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/sterile-and-aseptic-sampling/automated-aseptic-sampling) - [Sterile Filtration & Bioburden Control](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/sterile-filtration-and-bioburden-control) - [Buffer Filtration](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/buffer-media-prep/buffer-filtration) - [Filter Housings](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/sterile-filtration-and-bioburden-control/filter-housings) - [Final Sterile Filtration & Filling](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/sterile-filtration-and-bioburden-control/final-sterile-filtration-and-filling) - [Gas & Vent Filters](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/sterile-filtration-and-bioburden-control/gas-and-vent-filters) - [Integrity Testers](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/sterile-filtration-and-bioburden-control/integrity-testers) - [Media Filtration](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/buffer-media-prep/media-filtration) - [Prefilters & Bioburden Control](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/sterile-filtration-and-bioburden-control/prefilters-and-bioburden-control) - [Sterile Filters](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/sterile-filtration-and-bioburden-control/sterile-filters) - [Ultrafiltration & Diafiltration](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/ultrafiltration-diafiltration) - [Tangential Flow Filtration Devices](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/ultrafiltration-diafiltration/filtration-devices) - [Tangential Flow Filtration Holders & Systems](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/ultrafiltration-diafiltration/tangential-flow-holders-systems) - [Viral Clearance](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/viral-clearance) - [Integrity Testers](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/sterile-filtration-and-bioburden-control/integrity-testers) - [Virus Filter Holders & Systems](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/viral-clearance/virus-filter-holders-and-systems) - [Virus Filters](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/viral-clearance/virus-filters) - [Virus Inactivation](https://www.sigmaaldrich.com/US/en/products/pharma-and-biopharma-manufacturing/viral-clearance/virus-inactivation) - [Protein Biology](https://www.sigmaaldrich.com/US/en/products/protein-biology) - [Antibodies](https://www.sigmaaldrich.com/US/en/products/protein-biology/antibodies) - [Enhanced Validation Antibodies](https://www.sigmaaldrich.com/US/en/products/protein-biology/antibodies/enhanced-validation-ab) - [Flow Cytometry Antibodies](https://www.sigmaaldrich.com/US/en/products/protein-biology/antibodies/flow-cytometry-antibodies) - [Prestige Antibodies^®](https://www.sigmaaldrich.com/US/en/products/protein-biology/antibodies/prestige-antibodies) - [Primary Antibodies](https://www.sigmaaldrich.com/US/en/products/protein-biology/antibodies/primary-antibodies) - [Secondary Antibodies](https://www.sigmaaldrich.com/US/en/products/protein-biology/antibodies/secondary-antibodies) - [Small Pack Antibodies](https://www.sigmaaldrich.com/US/en/products/protein-biology/antibodies/small-pack-antibodies) - [ZooMAb^® Recombinant Antibodies](https://www.sigmaaldrich.com/US/en/products/protein-biology/antibodies/zoomab-antibodies) - [Bioactive Small Molecules](https://www.sigmaaldrich.com/US/en/products/protein-biology/bioactive-small-molecules) - [Structural Genomics Consortium](https://www.sigmaaldrich.com/US/en/products/protein-biology/bioactive-small-molecules/structural-genomics-consortium) - [Duolink^® PLA - Protein Interaction Technology](https://www.sigmaaldrich.com/US/en/products/protein-biology/duolink-proximity-ligation-assay) - [Immunoassay Platform Solutions](https://www.sigmaaldrich.com/US/en/products/protein-biology/immunoassay-platform-solutions) - [ELISA Kits](https://www.sigmaaldrich.com/US/en/products/protein-biology/immunoassay-platform-solutions/elisa-kits) - [MILLIPLEX^® Kits](https://www.sigmaaldrich.com/US/en/products/protein-biology/immunoassay-platform-solutions/milliplex-multiplex-assays-for-luminex-technology) - [SMC^™ Technology](https://www.sigmaaldrich.com/US/en/products/protein-biology/immunoassay-platform-solutions/single-molecule-counting-technology) - [Protein Electrophoresis & Western Blotting](https://www.sigmaaldrich.com/US/en/products/protein-biology/protein-electrophoresis-and-western-blotting) - [Electrophoresis & Transfer Equipment](https://www.sigmaaldrich.com/US/en/products/protein-biology/protein-electrophoresis-and-western-blotting/electrophoresis-and-transfer-equipment) - [Transfer Membranes & Kits](https://www.sigmaaldrich.com/US/en/products/protein-biology/protein-electrophoresis-and-western-blotting/transfer-membranes-and-kits) - [Immunodetection Reagents & Substrates](https://www.sigmaaldrich.com/US/en/products/protein-biology/protein-electrophoresis-and-western-blotting/immunodetection-reagents-and-substrates) - [Membrane Immunodetection Devices](https://www.sigmaaldrich.com/US/en/products/protein-biology/protein-electrophoresis-and-western-blotting/membrane-immunodetection-devices) - [Protein Electrophoresis Gels & Buffers](https://www.sigmaaldrich.com/US/en/products/protein-biology/protein-electrophoresis-and-western-blotting/protein-electrophoresis-gels-and-buffers) - [Protein Electrophoresis Gel Stains](https://www.sigmaaldrich.com/US/en/products/protein-biology/protein-electrophoresis-and-western-blotting/protein-electrophoresis-gel-stains) - [Protein Markers](https://www.sigmaaldrich.com/US/en/products/protein-biology/protein-electrophoresis-and-western-blotting/protein-markers) - [Transfer Buffers & Reagents](https://www.sigmaaldrich.com/US/en/products/protein-biology/protein-electrophoresis-and-western-blotting/transfer-buffers-and-reagents) - [Proteins & Enzymes](https://www.sigmaaldrich.com/US/en/products/protein-biology/proteins-and-enzymes) - [Albumins & Transport Proteins](https://www.sigmaaldrich.com/US/en/products/cell-culture-and-analysis/cell-culture-supplements-and-reagents/albumins-and-transport-proteins) - [Coenzymes](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/biochemicals/coenzymes) - [Detection Substrates & Enzymes](https://www.sigmaaldrich.com/US/en/products/protein-biology/proteins-and-enzymes/detection-substrates-and-enzymes) - [Drug Analysis Enzymes](https://www.sigmaaldrich.com/US/en/products/protein-biology/proteins-and-enzymes/drug-analysis-enzymes) - [Glycobiology Profiling Tools](https://www.sigmaaldrich.com/US/en/products/protein-biology/proteins-and-enzymes/glycosidases) - [Nucleases](https://www.sigmaaldrich.com/US/en/products/protein-biology/proteins-and-enzymes/nucleases) - [Proteases](https://www.sigmaaldrich.com/US/en/products/protein-biology/proteins-and-enzymes/proteases) - [Tissue Dissociation](https://www.sigmaaldrich.com/US/en/products/protein-biology/proteins-and-enzymes/tissue-dissociation) - [Protein Mass Spectrometry](https://www.sigmaaldrich.com/US/en/products/protein-biology/protein-mass-spectrometry) - [Protein Purification Chromatography](https://www.sigmaaldrich.com/US/en/products/protein-biology/protein-purification-chromatography) - [Antibody Protein Purification](https://www.sigmaaldrich.com/US/en/products/protein-biology/protein-sample-prep/antibody-protein-purification) - [Biotinylated Protein Purification](https://www.sigmaaldrich.com/US/en/products/protein-biology/protein-sample-prep/biotinylated-protein-purification) - [FLAG^® Purification](https://www.sigmaaldrich.com/US/en/products/protein-biology/protein-sample-prep/flag-purification) - [Recombinant/Fusion Tag Protein Purification](https://www.sigmaaldrich.com/US/en/products/protein-biology/protein-sample-prep/recombinant-fusion-tag-protein-purification) - [Protein Sample Prep](https://www.sigmaaldrich.com/US/en/products/protein-biology/protein-sample-prep) - [Amicon^® Centrifugals](https://www.sigmaaldrich.com/US/en/products/protein-biology/protein-sample-prep/amicon-centrifugals) - [Antibody Protein Purification](https://www.sigmaaldrich.com/US/en/products/protein-biology/protein-sample-prep/antibody-protein-purification) - [Biotinylated Protein Purification](https://www.sigmaaldrich.com/US/en/products/protein-biology/protein-sample-prep/biotinylated-protein-purification) - [FLAG^® Purification](https://www.sigmaaldrich.com/US/en/products/protein-biology/protein-sample-prep/flag-purification) - [Inhibitor Cocktails](https://www.sigmaaldrich.com/US/en/products/protein-biology/protein-sample-prep/inhibitor-cocktails) - [Laboratory Concentration Devices](https://www.sigmaaldrich.com/US/en/products/protein-biology/protein-sample-prep/laboratory-concentration-devices) - [Laboratory Dialysis & Diafiltration Devices](https://www.sigmaaldrich.com/US/en/products/protein-biology/protein-sample-prep/laboratory-dialysis-and-diafiltration-devices) - [Recombinant/Fusion Tag Protein Purification](https://www.sigmaaldrich.com/US/en/products/protein-biology/protein-sample-prep/recombinant-fusion-tag-protein-purification) - [Subcellular Fractionation Reagents](https://www.sigmaaldrich.com/US/en/products/protein-biology/protein-sample-prep/subcellular-fractionation-reagents) - [Whole Cell Lysis Reagents & Enhancers](https://www.sigmaaldrich.com/US/en/products/protein-biology/protein-sample-prep/whole-cell-lysis-reagents-and-enhancers) - [Water Purification](https://www.sigmaaldrich.com/US/en/products/water-purification) - [Milli-Q^® Benchtop Water Purification Systems](https://www.sigmaaldrich.com/US/en/products/water-purification/milli-q-benchtop-water-purification-systems) - [Milli-Q^® High-Flow Water Purification Systems](https://www.sigmaaldrich.com/US/en/products/water-purification/milli-q-high-flow-water-purification-systems) - [Milli-Q^® Clinical Water Purification Systems](https://www.sigmaaldrich.com/US/en/products/water-purification/milli-q-clinical-water-purification-systems) - [Milli-Q^® Consumables](https://www.sigmaaldrich.com/US/en/products/water-purification/milli-q-consumables) - [Milli-Q^® Accessories](https://www.sigmaaldrich.com/US/en/products/water-purification/milli-q-accessories) - Applications - [Analytical Chemistry](https://www.sigmaaldrich.com/US/en/applications/analytical-chemistry) - [Atomic Spectroscopy](https://www.sigmaaldrich.com/US/en/applications/analytical-chemistry/atomic-spectroscopy) - [Calibration, Qualification, Validation](https://www.sigmaaldrich.com/US/en/applications/analytical-chemistry/calibration-qualification-and-validation) - [Gas Chromatography (GC)](https://www.sigmaaldrich.com/US/en/applications/analytical-chemistry/gas-chromatography) - [Liquid Chromatography](https://www.sigmaaldrich.com/US/en/applications/analytical-chemistry/liquid-chromatography) - [Large Molecule HPLC](https://www.sigmaaldrich.com/US/en/applications/analytical-chemistry/liquid-chromatography/large-molecule-hplc) - [Low Pressure Liquid Chromatography](https://www.sigmaaldrich.com/US/en/applications/analytical-chemistry/liquid-chromatography/low-pressure-liquid-chromatography) - [Small Molecule HPLC](https://www.sigmaaldrich.com/US/en/applications/analytical-chemistry/liquid-chromatography/small-molecule-hplc) - [Mass Spectrometry (MS)](https://www.sigmaaldrich.com/US/en/applications/analytical-chemistry/mass-spectrometry) - [Nuclear Magnetic Resonance (NMR)](https://www.sigmaaldrich.com/US/en/applications/analytical-chemistry/nuclear-magnetic-resonance) - [Photometry & Reflectometry](https://www.sigmaaldrich.com/US/en/applications/analytical-chemistry/photometry-and-reflectometry) - [Sample Preparation](https://www.sigmaaldrich.com/US/en/applications/analytical-chemistry/sample-preparation) - [Sample Filtration](https://www.sigmaaldrich.com/US/en/applications/analytical-chemistry/sample-preparation/filtration) - [Sample Purification](https://www.sigmaaldrich.com/US/en/applications/analytical-chemistry/sample-preparation/purification) - [QuEChERS Sample Preparation](https://www.sigmaaldrich.com/US/en/applications/analytical-chemistry/sample-preparation/quechers) - [Solid Phase Extraction](https://www.sigmaaldrich.com/US/en/applications/analytical-chemistry/sample-preparation/solid-phase-extraction) - [Solid Phase Microextraction](https://www.sigmaaldrich.com/US/en/applications/analytical-chemistry/sample-preparation/solid-phase-microextraction) - [Thin Layer Chromatography (TLC)](https://www.sigmaaldrich.com/US/en/applications/analytical-chemistry/thin-layer-chromatography) - [Titration & Karl Fischer](https://www.sigmaaldrich.com/US/en/applications/analytical-chemistry/titration-and-karl-fischer) - [Water for Analytical Chemistry](https://www.sigmaaldrich.com/US/en/applications/water-purification/water-analytical-chemistry) - [Wet Chemical Analysis](https://www.sigmaaldrich.com/US/en/applications/analytical-chemistry/wet-chemical-analysis) - [Cell Culture & Analysis](https://www.sigmaaldrich.com/US/en/applications/cell-culture-and-cell-culture-analysis) - [Cell Analysis](https://www.sigmaaldrich.com/US/en/applications/cell-culture-and-cell-culture-analysis/cell-analysis) - [Cell-based Assays](https://www.sigmaaldrich.com/US/en/applications/cell-culture-and-cell-culture-analysis/cell-analysis/cell-based-assays) - [Cell Counting & Health analysis](https://www.sigmaaldrich.com/US/en/applications/cell-culture-and-cell-culture-analysis/cell-analysis/cell-counting-and-health-analysis) - [Imaging Analysis & Live Cell Imaging](https://www.sigmaaldrich.com/US/en/applications/cell-culture-and-cell-culture-analysis/cell-analysis/imaging-analysis-and-live-cell-imaging) - [Cell Culture by Cell Type](https://www.sigmaaldrich.com/US/en/applications/cell-culture-and-cell-culture-analysis/cell-culture-by-cell-type) - [Mammalian Cell Culture](https://www.sigmaaldrich.com/US/en/applications/cell-culture-and-cell-culture-analysis/cell-culture-by-cell-type/mammalian-cell-culture) - [Microbial Cell Culture](https://www.sigmaaldrich.com/US/en/applications/cell-culture-and-cell-culture-analysis/cell-culture-by-cell-type/microbial-cell-culture) - [Plant Tissue Culture](https://www.sigmaaldrich.com/US/en/applications/cell-culture-and-cell-culture-analysis/cell-culture-by-cell-type/plant-tissue-culture) - [Primary Cell Culture](https://www.sigmaaldrich.com/US/en/applications/cell-culture-and-cell-culture-analysis/cell-culture-by-cell-type/primary-cell-culture) - [Stem Cell Culture](https://www.sigmaaldrich.com/US/en/applications/cell-culture-and-cell-culture-analysis/cell-culture-by-cell-type/stem-cell-culture) - [Cell Culture by Technique](https://www.sigmaaldrich.com/US/en/applications/cell-culture-and-cell-culture-analysis/cell-culture-by-technique) - [3D Cell Culture](https://www.sigmaaldrich.com/US/en/applications/cell-culture-and-cell-culture-analysis/cell-culture-by-technique/3d-cell-culture) - [Cell Culture Media Preparation](https://www.sigmaaldrich.com/US/en/applications/cell-culture-and-cell-culture-analysis/cell-culture-by-technique/cell-culture-media-preparation) - [Cell Growth & Maintenance](https://www.sigmaaldrich.com/US/en/applications/cell-culture-and-cell-culture-analysis/cell-culture-by-technique/cell-growth-and-maintenance) - [Transfection & Gene Editing](https://www.sigmaaldrich.com/US/en/applications/cell-culture-and-cell-culture-analysis/cell-culture-by-technique/transfection-and-gene-editing) - [Cell Culture for Manufacturing](https://www.sigmaaldrich.com/US/en/applications/cell-culture-and-cell-culture-analysis/cell-culture-for-manufacturing) - [Cell Culture Troubleshooting](https://www.sigmaaldrich.com/US/en/applications/cell-culture-and-cell-culture-analysis/cell-culture-troubleshooting) - [Chemistry & Synthesis](https://www.sigmaaldrich.com/US/en/applications/chemistry-and-synthesis) - [ADC & Bioconjugation](https://www.sigmaaldrich.com/US/en/applications/chemistry-and-synthesis/adc-and-bioconjugation) - [Lead Discovery](https://www.sigmaaldrich.com/US/en/applications/chemistry-and-synthesis/lead-discovery) - [Peptide Synthesis](https://www.sigmaaldrich.com/US/en/applications/chemistry-and-synthesis/peptide-synthesis) - [Protein Degradation](https://www.sigmaaldrich.com/US/en/applications/chemistry-and-synthesis/protein-degradation) - [Reaction Design & Optimization](https://www.sigmaaldrich.com/US/en/applications/chemistry-and-synthesis/reaction-design-and-optimization) - [Synthetic Methods](https://www.sigmaaldrich.com/US/en/applications/chemistry-and-synthesis/synthetic-methods) - [C-H Functionalization](https://www.sigmaaldrich.com/US/en/applications/chemistry-and-synthesis/synthetic-methods/ch-functionalization) - [Cross Coupling](https://www.sigmaaldrich.com/US/en/applications/chemistry-and-synthesis/synthetic-methods/cross-coupling) - [Fluorination](https://www.sigmaaldrich.com/US/en/applications/chemistry-and-synthesis/synthetic-methods/fluorination) - [Metathesis](https://www.sigmaaldrich.com/US/en/applications/chemistry-and-synthesis/synthetic-methods/metathesis) - [Organic Reaction Toolbox](https://www.sigmaaldrich.com/US/en/applications/chemistry-and-synthesis/synthetic-methods/organic-reaction-toolbox) - [Photocatalysis](https://www.sigmaaldrich.com/US/en/applications/chemistry-and-synthesis/synthetic-methods/photocatalysis) - [Clinical & Diagnostics](https://www.sigmaaldrich.com/US/en/applications/clinical-testing-and-diagnostics-manufacturing) - [Bacteriology](https://www.sigmaaldrich.com/US/en/applications/clinical-testing-and-diagnostics-manufacturing/bacteriology) - [Blood Typing](https://www.sigmaaldrich.com/US/en/applications/clinical-testing-and-diagnostics-manufacturing/blood-typing) - [Clinical & Forensics Testing](https://www.sigmaaldrich.com/US/en/applications/clinical-testing-and-diagnostics-manufacturing/clinical-and-forensic-testing) - [Cytology & Cytodiagnosis](https://www.sigmaaldrich.com/US/en/applications/clinical-testing-and-diagnostics-manufacturing/cytology-and-microscopy) - [Diagnostic Immunohistochemistry](https://www.sigmaaldrich.com/US/en/applications/clinical-testing-and-diagnostics-manufacturing/diagnostic-immunohistochemistry) - [Hematology](https://www.sigmaaldrich.com/US/en/applications/clinical-testing-and-diagnostics-manufacturing/hematology) - [Histology/Histopathology](https://www.sigmaaldrich.com/US/en/applications/clinical-testing-and-diagnostics-manufacturing/histology) - [IVD Manufacturing](https://www.sigmaaldrich.com/US/en/applications/clinical-testing-and-diagnostics-manufacturing/ivd-manufacturing) - [Water for Clinical Diagnostics](https://www.sigmaaldrich.com/US/en/applications/water-purification/water-clinical-diagnostics) - [Environmental & Cannabis Testing](https://www.sigmaaldrich.com/US/en/applications/environmental-testing-and-industrial-hygiene) - [Air Sampling & Monitoring](https://www.sigmaaldrich.com/US/en/applications/environmental-testing-and-industrial-hygiene/air-testing) - [Cannabis Testing](https://www.sigmaaldrich.com/US/en/applications/environmental-testing-and-industrial-hygiene/cannabis-testing) - [Cannabinoids & Potency](https://www.sigmaaldrich.com/US/en/applications/environmental-testing-and-industrial-hygiene/cannabis-testing/cannabinoid-profiling-potency-testing) - [Pesticides & Mycotoxins](https://www.sigmaaldrich.com/US/en/applications/environmental-testing-and-industrial-hygiene/cannabis-testing/pesticides-mycotoxins-in-cannabis) - [Terpenes](https://www.sigmaaldrich.com/US/en/applications/environmental-testing-and-industrial-hygiene/cannabis-testing/terpenes-cannabis) - [Drinking Water Testing​](https://www.sigmaaldrich.com/US/en/applications/environmental-testing-and-industrial-hygiene/drinking-water-testing) - [Soil, Solid Waste, & Groundwater Testing](https://www.sigmaaldrich.com/US/en/applications/environmental-testing-and-industrial-hygiene/soil-solid-waste-groundwater-testing) - [Waste Water & Process Water Testing](https://www.sigmaaldrich.com/US/en/applications/environmental-testing-and-industrial-hygiene/waste-water-and-process-water-testing) - [Food & Beverage Testing & Manufacturing](https://www.sigmaaldrich.com/US/en/applications/food-and-beverage-testing-and-manufacturing) - [Chemical Analysis](https://www.sigmaaldrich.com/US/en/applications/food-and-beverage-testing-and-manufacturing/chemical-analysis-for-food-and-beverage) - [Flavor & Fragrance Formulation](https://www.sigmaaldrich.com/US/en/applications/food-and-beverage-testing-and-manufacturing/flavor-and-fragrance-formulation) - [Microbiological Analysis](https://www.sigmaaldrich.com/US/en/applications/food-and-beverage-testing-and-manufacturing/microbiological-analysis-for-food-and-beverage) - [Regulatory Compliance​](https://www.sigmaaldrich.com/US/en/applications/food-and-beverage-testing-and-manufacturing/regulatory-compliance-for-food-and-beverage) - [Genomics](https://www.sigmaaldrich.com/US/en/applications/genomics) - [Advanced Gene Editing](https://www.sigmaaldrich.com/US/en/applications/genomics/advanced-gene-editing) - [Cloning & Expression](https://www.sigmaaldrich.com/US/en/applications/genomics/cloning-and-expression) - [DNA & RNA Purification](https://www.sigmaaldrich.com/US/en/applications/genomics/dna-and-rna-purification) - [Epigenetics](https://www.sigmaaldrich.com/US/en/applications/genomics/epigenetics) - [Functional Genomics Screening](https://www.sigmaaldrich.com/US/en/applications/genomics/functional-genomics-screening) - [Gene Expression & Silencing](https://www.sigmaaldrich.com/US/en/applications/genomics/gene-expression-and-silencing) - [Next Gen Sequencing](https://www.sigmaaldrich.com/US/en/applications/genomics/next-gen-sequencing) - [Nucleic Acid Gel Electrophoresis](https://www.sigmaaldrich.com/US/en/applications/genomics/nucleic-acid-gel-electrophoresis) - [Nucleic Acid Labeling & Detection](https://www.sigmaaldrich.com/US/en/applications/genomics/nucleic-acid-labeling-and-detection) - [PCR](https://www.sigmaaldrich.com/US/en/applications/genomics/pcr) - [qPCR](https://www.sigmaaldrich.com/US/en/applications/genomics/qpcr) - [Sequencing](https://www.sigmaaldrich.com/US/en/applications/genomics/sequencing) - [Materials Science & Engineering](https://www.sigmaaldrich.com/US/en/applications/materials-science-and-engineering) - [3D Bioprinting](https://www.sigmaaldrich.com/US/en/applications/materials-science-and-engineering/3d-bioprinting) - [3D Printing](https://www.sigmaaldrich.com/US/en/applications/materials-science-and-engineering/3d-printing) - [Batteries, Supercapacitors, Fuel Cells](https://www.sigmaaldrich.com/US/en/applications/materials-science-and-engineering/batteries-supercapacitors-and-fuel-cells) - [Bioelectronics](https://www.sigmaaldrich.com/US/en/applications/materials-science-and-engineering/bioelectronics) - [Biosensors & Bioimaging](https://www.sigmaaldrich.com/US/en/applications/materials-science-and-engineering/biosensors-and-bioimaging) - [Chemical Vapor Deposition](https://www.sigmaaldrich.com/US/en/applications/materials-science-and-engineering/chemical-vapor-deposition) - [Contact Lens & Dental Manufacturing](https://www.sigmaaldrich.com/US/en/applications/materials-science-and-engineering/contact-lens-and-dental-manufacturing) - [Drug Delivery](https://www.sigmaaldrich.com/US/en/applications/materials-science-and-engineering/drug-delivery) - [Electron Microscopy](https://www.sigmaaldrich.com/US/en/applications/materials-science-and-engineering/electron-microscopy) - [Microelectronics & Nanoelectronics](https://www.sigmaaldrich.com/US/en/applications/materials-science-and-engineering/microelectronics-and-nanoelectronics) - [Nanoparticle & Microparticle Synthesis](https://www.sigmaaldrich.com/US/en/applications/materials-science-and-engineering/nanoparticle-and-microparticle-synthesis) - [Organic Electronics](https://www.sigmaaldrich.com/US/en/applications/materials-science-and-engineering/organic-electronics) - [Photovoltaics & Solar Cells](https://www.sigmaaldrich.com/US/en/applications/materials-science-and-engineering/photovoltaics-and-solar-cells) - [Polymer Synthesis](https://www.sigmaaldrich.com/US/en/applications/materials-science-and-engineering/polymer-synthesis) - [Solid State Synthesis](https://www.sigmaaldrich.com/US/en/applications/materials-science-and-engineering/solid-state-synthesis) - [Tissue Engineering](https://www.sigmaaldrich.com/US/en/applications/materials-science-and-engineering/tissue-engineering) - [Microbiological Testing](https://www.sigmaaldrich.com/US/en/applications/microbiological-testing) - [Bioburden Testing](https://www.sigmaaldrich.com/US/en/applications/microbiological-testing/bioburden-testing) - [Culture Media Preparation](https://www.sigmaaldrich.com/US/en/applications/microbiological-testing/microbial-culture-media-preparation) - [Media Fill (APS)](https://www.sigmaaldrich.com/US/en/applications/microbiological-testing/media-fills) - [Microbial Water Testing](https://www.sigmaaldrich.com/US/en/applications/microbiological-testing/microbial-water-testing) - [Mycoplasma Testing](https://www.sigmaaldrich.com/US/en/applications/microbiological-testing/mycoplasma-testing) - [Pathogen & Spoilage Testing](https://www.sigmaaldrich.com/US/en/applications/microbiological-testing/pathogen-and-spoilage-testing) - [Pyrogen Testing](https://www.sigmaaldrich.com/US/en/applications/microbiological-testing/pyrogen-testing) - [Sterility Testing](https://www.sigmaaldrich.com/US/en/applications/microbiological-testing/sterility-testing) - [Surface & Personnel Testing](https://www.sigmaaldrich.com/US/en/applications/microbiological-testing/surface-and-personnel-testing) - [Viable Air Monitoring](https://www.sigmaaldrich.com/US/en/applications/microbiological-testing/viable-air-monitoring) - [mAbs Development & Manufacturing](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies) - [Antibody Drug Discovery](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies/antibody-drug-discovery) - [Lead Selection & Optimization](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies/antibody-drug-discovery/lead-discovery) - [Preclinical Development](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies/antibody-drug-discovery/preclinical-development) - [Target Discovery](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies/antibody-drug-discovery/target-discovery) - [Characterization & Quality Control](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies/characterization-and-quality-control) - [Aggregate Analysis](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies/characterization-and-quality-control/aggregate-analysis) - [Intact Mass Analysis](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies/characterization-and-quality-control/intact-mass-analysis) - [Peptide Mapping](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies/characterization-and-quality-control/peptide-mapping) - [Post-Translational Modification](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies/characterization-and-quality-control/post-translational-modification-analysis) - [Titer Determination](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies/characterization-and-quality-control/titer-determination) - [Process Development, Manufacturing, Formulation & Final Fill](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies/process-development-manufacturing) - [Downstream Processing (DSP)](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies/process-development-manufacturing/downstream-processing-mabs) - [Formulation & Final Fill](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies/process-development-manufacturing/formulation-final-fill-mabs) - [Upstream Processing (USP)](https://www.sigmaaldrich.com/US/en/integrated-offerings/monoclonal-antibodies/process-development-manufacturing/upstream-processing-mabs) - [mRNA Development & Manufacturing](https://www.sigmaaldrich.com/US/en/integrated-offerings/mrna-development-manufacturing) - [mRNA Analytical & Quality Control](https://www.sigmaaldrich.com/US/en/integrated-offerings/mrna-development-manufacturing/mrna-analytical-quality-control) - [mRNA Development](https://www.sigmaaldrich.com/US/en/integrated-offerings/mrna-development-manufacturing/mrna-development) - [mRNA Manufacturing & Formulation](https://www.sigmaaldrich.com/US/en/integrated-offerings/mrna-development-manufacturing/mrna-manufacturing-formulation) - [mRNA Research](https://www.sigmaaldrich.com/US/en/integrated-offerings/mrna-development-manufacturing/mrna-research) - [Pharma & Biopharma Manufacturing](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing) - [Antibody Drug Conjugate Manufacturing](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/adc-manufacturing) - [Conjugation](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/adc-manufacturing/conjugation) - [Purification](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/adc-manufacturing/antibody-drug-conjugate-manufacturing-purification) - [Biopharma 4.0](https://www.sigmaaldrich.com/US/en/integrated-offerings/biopharma-4-0) - [Bioprocessing Automation & Control Software](https://www.sigmaaldrich.com/US/en/integrated-offerings/biopharma-4-0/bioprocessing-automation-control-software) - [Bioprocessing Data Analytics Software](https://www.sigmaaldrich.com/US/en/integrated-offerings/biopharma-4-0/bioprocessing-data-analytics-software) - [Closed Processing for Biomanufacturing](https://www.sigmaaldrich.com/US/en/integrated-offerings/biopharma-4-0/closed-processing-for-biomanufacturing) - [Intensified & Continuous Upstream (USP) Processing](https://www.sigmaaldrich.com/US/en/integrated-offerings/biopharma-4-0/intensified-upstream-processing) - [Intensified & Continuous Downstream (DSP) Processing](https://www.sigmaaldrich.com/US/en/integrated-offerings/biopharma-4-0/intensified-continuous-downstream-processing) - [Process Analytical Technology (PAT)](https://www.sigmaaldrich.com/US/en/integrated-offerings/biopharma-4-0/process-analytical-technology) - [Biotech Resource Hub](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/biotech-resource-hub) - [Discovery](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/biotech-resource-hub/discovery) - [Pre-clinical](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/biotech-resource-hub/pre-clinical) - [Phase I-II](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/biotech-resource-hub/phase-i-ii) - [Phase III and Manufacturing](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/biotech-resource-hub/phase-iii-and-manufacturing) - [Regulatory](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/biotech-resource-hub/regulatory) - [Startup Programs](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/biotech-resource-hub/startup-programs) - [Blood Plasma Fractionation](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/plasma-manufacturing) - [Cell Therapy Manufacturing](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/cell-therapy-manufacturing) - [Classical Pharma Manufacturing](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/classical-pharma-manufacturing) - [Final Fill Strategies](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/classical-pharma-manufacturing/final-fill-strategies) - [Liquid Formulation Strategies](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/classical-pharma-manufacturing/liquid-formulation-strategies) - [Solid Formulation Strategies](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/classical-pharma-manufacturing/solid-formulation-strategies) - [Sterile Filtration Strategies](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/classical-pharma-manufacturing/sterile-filtration-strategies) - [Gene Therapy Manufacturing](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/gene-therapy-manufacturing) - [Viral Vector Upstream Processing](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/gene-therapy-manufacturing/viral-vector-upstream-processing) - [Viral Vector Downstream Processing](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/gene-therapy-manufacturing/viral-vector-downstream-processing) - [Viral Vector Formulation & Final Fill](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/gene-therapy-manufacturing/viral-vector-formulation-and-final-fill) - [Viral Vector Characterization & Biosafety Testing](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/gene-therapy-manufacturing/viral-vector-characterization-and-biosafety-testing) - [Viral Vector Contract Development & Manufacturing](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/gene-therapy-manufacturing/viral-vector-contract-development-and-manufacturing) - [Pharma Analysis & QC](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/pharmaceutical-analysis-quality-control) - [Biologics & Biosimilars Characterization](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/pharmaceutical-analysis-quality-control/biologics-biosimilars-characterization) - [Compendial Testing & Regulatory Guidance](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/pharmaceutical-analysis-quality-control/compendial-testing-regulatory-guidance) - [Small Molecules Analysis & Quality Control (QC)](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/pharmaceutical-analysis-quality-control/small-molecules-analysis-quality-control) - [Sterile & Aseptic Sampling](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/sampling) - [Vaccine Manufacturing](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/vaccine-manufacturing) - [Cell-Based Vaccine Manufacturing](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/vaccine-manufacturing/cell-based-vaccine-manufacturing) - [mRNA Vaccine Manufacturing](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/vaccine-manufacturing/mrna-vaccines-process-manufacturing) - [pDNA Vaccine Manufacturing](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/vaccine-manufacturing/plasmid-dna-vaccines-manufacturing) - [Protein Subunit Vaccine Manufacturing](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/vaccine-manufacturing/protein-subunit-vaccine-manufacturing) - [Viral-like Particles Vaccine Manufacturing](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/vaccine-manufacturing/viral-like-particles-vaccine-manufacturing) - [Viral Vector Vaccine Manufacturing](https://www.sigmaaldrich.com/US/en/applications/pharmaceutical-and-biopharmaceutical-manufacturing/vaccine-manufacturing/viral-vector-vaccine-manufacturing) - [Protein Biology](https://www.sigmaaldrich.com/US/en/applications/protein-biology) - [ELISA](https://www.sigmaaldrich.com/US/en/applications/protein-biology/elisa) - [Enzyme Activity Assays](https://www.sigmaaldrich.com/US/en/applications/protein-biology/enzyme-activity-assays) - [Flow Cytometry](https://www.sigmaaldrich.com/US/en/applications/protein-biology/flow-cytometry) - [Gel Electrophoresis](https://www.sigmaaldrich.com/US/en/applications/protein-biology/gel-electrophoresis) - [Immunohistochemistry](https://www.sigmaaldrich.com/US/en/applications/protein-biology/immunohistochemistry) - [Interrogation of Protein Pathways](https://www.sigmaaldrich.com/US/en/applications/protein-biology/interrogation-protein-pathways) - [Lysis & Protein Extraction](https://www.sigmaaldrich.com/US/en/applications/protein-biology/lysis-and-protein-extraction) - [Protein & Nucleic Acid Interactions](https://www.sigmaaldrich.com/US/en/applications/protein-biology/protein-and-nucleic-acid-interactions) - [Protein Concentration & Buffer Exchange](https://www.sigmaaldrich.com/US/en/applications/protein-biology/protein-concentration-and-buffer-exchange) - [Protein Expression](https://www.sigmaaldrich.com/US/en/applications/protein-biology/protein-expression) - [Protein Labeling & Modification](https://www.sigmaaldrich.com/US/en/applications/protein-biology/protein-labeling-and-modification) - [Protein Pulldown](https://www.sigmaaldrich.com/US/en/applications/protein-biology/protein-pulldown) - [Protein Purification](https://www.sigmaaldrich.com/US/en/applications/protein-biology/protein-purification) - [Protein Quantitation](https://www.sigmaaldrich.com/US/en/applications/protein-biology/protein-quantitation) - [Protein Structural Analysis](https://www.sigmaaldrich.com/US/en/applications/protein-biology/protein-structural-analysis) - [Western Blotting](https://www.sigmaaldrich.com/US/en/applications/protein-biology/western-blotting) - [Protein Mass Spectrometry](https://www.sigmaaldrich.com/US/en/applications/protein-biology/protein-mass-spectrometry) - [Research & Disease Areas](https://www.sigmaaldrich.com/US/en/applications/research-disease-areas) - [Cancer Research](https://www.sigmaaldrich.com/US/en/applications/research-disease-areas/cancer-research) - [Cell & Developmental Biology Research](https://www.sigmaaldrich.com/US/en/applications/research-disease-areas/cell-and-developmental-biology-research) - [Cell Signaling](https://www.sigmaaldrich.com/US/en/applications/research-disease-areas/cell-signaling) - [Glycobiology](https://www.sigmaaldrich.com/US/en/applications/research-disease-areas/glycobiology) - [Metabolomics Research](https://www.sigmaaldrich.com/US/en/applications/research-disease-areas/metabolomics-research) - [Neuroscience Research](https://www.sigmaaldrich.com/US/en/applications/research-disease-areas/neuroscience-research) - [Pharmacology & Drug Discovery Research](https://www.sigmaaldrich.com/US/en/applications/research-disease-areas/pharmacology-and-drug-discovery-research) - [Water Purification](https://www.sigmaaldrich.com/US/en/applications/water-purification) - [Water for Analytical Chemistry](https://www.sigmaaldrich.com/US/en/applications/water-purification/water-analytical-chemistry) - [Water for Cell & Molecular Biology](https://www.sigmaaldrich.com/US/en/applications/water-purification/water-cell-molecular-biology) - [Water for Clinical Diagnostics](https://www.sigmaaldrich.com/US/en/applications/water-purification/water-clinical-diagnostics) - [Understanding Lab Water](https://www.sigmaaldrich.com/US/en/applications/water-purification/understanding-lab-water) - Services - [Contract Manufacturing](https://www.sigmaaldrich.com/US/en/services/contract-manufacturing) - [ADC & Bioconjugation](https://www.sigmaaldrich.com/US/en/services/contract-manufacturing/adc-bioconjugation) - [Diagnostic OEM & CMO Services](https://www.sigmaaldrich.com/US/en/services/ivd-development-manufacturing/diagnostic-oem-cmo) - [mRNA & LNP](https://www.sigmaaldrich.com/US/en/services/contract-manufacturing/mrna-and-lnp-formulation-ctdmo-services) - [Lipids CDMO Services](https://www.sigmaaldrich.com/US/en/services/contract-manufacturing/mrna-and-lnp-formulation-ctdmo-services/lipids-cdmo-services) - [Lipid Nanoparticle CDMO Service](https://www.sigmaaldrich.com/US/en/services/contract-manufacturing/mrna-and-lnp-formulation-ctdmo-services/lipid-nanoparticle-cdmo-services) - [Small Molecule](https://www.sigmaaldrich.com/US/en/services/contract-manufacturing/small-molecule) - [Activated Polyethylene Glycol (PEGs)](https://www.sigmaaldrich.com/US/en/services/contract-manufacturing/peg) - [APIs](https://www.sigmaaldrich.com/US/en/services/contract-manufacturing/complex-apis) - [Highly Potent APIs](https://www.sigmaaldrich.com/US/en/services/contract-manufacturing/high-potent-apis) - [Viral Vector](https://www.sigmaaldrich.com/US/en/services/contract-manufacturing/viral-vector-manufacturing) - [AAV Production](https://www.sigmaaldrich.com/US/en/services/contract-manufacturing/viral-vector-manufacturing/aav-production) - [Gene Therapy Process Development](https://www.sigmaaldrich.com/US/en/services/contract-manufacturing/viral-vector-manufacturing/gene-therapy-process-development) - [Lentiviral Vectors](https://www.sigmaaldrich.com/US/en/services/contract-manufacturing/viral-vector-manufacturing/lentiviral-vectors) - [Contract Testing](https://www.sigmaaldrich.com/US/en/services/contract-testing) - [Analytical Development](https://www.sigmaaldrich.com/US/en/services/contract-testing/analytical-development-product-characterization) - [ADC Product Characterization](https://www.sigmaaldrich.com/US/en/services/contract-testing/analytical-development-product-characterization/adc-characterization) - [Analytical Development and Characterization for Adeno-Associated Virus (AAV)](https://www.sigmaaldrich.com/US/en/services/contract-testing/analytical-development-product-characterization/analytical-development-characterization-adeno-associated-virus) - [mAb Product Characterization](https://www.sigmaaldrich.com/US/en/services/contract-testing/analytical-development-product-characterization/mab-characterization) - [mRNA Analytical Development](https://www.sigmaaldrich.com/US/en/services/contract-testing/analytical-development-product-characterization/mrna-analytical-development) - [Bulk Harvest Release Testing](https://www.sigmaaldrich.com/US/en/services/contract-testing/bulk-harvest-release-testing) - [Cell & Gene Therapy Bulk Harvest Release Testing](https://www.sigmaaldrich.com/US/en/services/contract-testing/bulk-harvest-release-testing/cell-gene-therapy) - [mAbs Bulk Harvest Release Testing](https://www.sigmaaldrich.com/US/en/services/contract-testing/bulk-harvest-release-testing/mabs-bulk) - [Vaccine Harvest Release Testing](https://www.sigmaaldrich.com/US/en/services/contract-testing/bulk-harvest-release-testing/vaccine) - [Cell & Virus Bank Manufacturing & Testing](https://www.sigmaaldrich.com/US/en/services/contract-testing/cell-viral-bank-testing) - [Biorepository & Storage](https://www.sigmaaldrich.com/US/en/services/contract-testing/cell-viral-bank-testing/storage) - [Cell Bank Manufacturing](https://www.sigmaaldrich.com/US/en/services/contract-testing/cell-viral-bank-testing/cell-bank-manufacturing) - [Cell Line Characterization](https://www.sigmaaldrich.com/US/en/services/contract-testing/cell-viral-bank-testing/cell-line-characterization) - [Genetic Stability Testing](https://www.sigmaaldrich.com/US/en/services/contract-testing/cell-viral-bank-testing/genetic-stability-testing) - [Virus Bank Manufacturing](https://www.sigmaaldrich.com/US/en/services/contract-testing/cell-viral-bank-testing/virus-bank-manufacturing) - [Final Product Release Testing](https://www.sigmaaldrich.com/US/en/services/contract-testing/final-product-release-testing) - [Cell & Gene Therapy Final Product Release Testing](https://www.sigmaaldrich.com/US/en/services/contract-testing/final-product-release-testing/cell-gene-therapy) - [mAbs Final Product Release Testing](https://www.sigmaaldrich.com/US/en/services/contract-testing/final-product-release-testing/mabs-product-release-testing) - [Rapid Molecular Detection](https://www.sigmaaldrich.com/US/en/services/contract-testing/rapid-molecular-detection) - [Blazar™ Rapid Molecular Detection](https://www.sigmaaldrich.com/US/en/services/contract-testing/rapid-molecular-detection/blazar-rapid-molecular-detection) - [Next Generation Sequencing](https://www.sigmaaldrich.com/US/en/services/contract-testing/rapid-molecular-detection/next-generation-sequencing) - [Raw Material Testing](https://www.sigmaaldrich.com/US/en/services/contract-testing/raw-material-testing) - [Stability Testing Services](https://www.sigmaaldrich.com/US/en/services/contract-testing/stability-testing-services) - [Viral Clearance Testing](https://www.sigmaaldrich.com/US/en/services/contract-testing/viral-clearance-testing) - [Provise^® Clearance Services](https://www.sigmaaldrich.com/US/en/services/contract-testing/viral-clearance-testing/complete-clearance) - [Standard & Hybrid Clearance Services](https://www.sigmaaldrich.com/US/en/services/contract-testing/viral-clearance-testing/standard-clearance) - [Custom Products](https://www.sigmaaldrich.com/US/en/services/custom-products) - [Bulk Powder Transfer Bags](https://www.sigmaaldrich.com/US/en/services/custom-products/bulk-powder-transfer-bags) - [CADI: Custom Assay Development & Innovation](https://www.sigmaaldrich.com/US/en/services/custom-products/custom-milliplex-multiplex-assays-and-elisas) - [Cell Culture Media Stability & Testing Services](https://www.sigmaaldrich.com/US/en/services/custom-products/cell-culture-media-stability-and-testing-services) - [Cell Design Studio™ Cell Engineering Services](https://www.sigmaaldrich.com/US/en/services/custom-products/custom-cell-lines) - [CHOZN^® Cell Line Engineering and Development](https://www.sigmaaldrich.com/US/en/services/custom-products/chozn-cell-line-engineering-and-development) - [Contract ZooMAb^® Antibody Development Services](https://www.sigmaaldrich.com/US/en/services/custom-products/contract-zoomab-antibody-development-services) - [Critical Raw Materials](https://www.sigmaaldrich.com/US/en/services/custom-products/critical-raw-materials) - [Custom Diagnostic Antibody Development & Manufacturing Services](https://www.sigmaaldrich.com/US/en/services/ivd-development-manufacturing/custom-diagnostic-antibody-development-and-manufacturing-services) - [Custom GC Columns](https://www.sigmaaldrich.com/US/en/services/custom-products/customized-gc-columns) - [Custom GMP Cell Culture Media](https://www.sigmaaldrich.com/US/en/services/custom-products/custom-gmp-cell-culture-products) - [Custom HPLC Columns](https://www.sigmaaldrich.com/US/en/services/custom-products/custom-hplc-column-request) - [Custom Media Development Services](https://www.sigmaaldrich.com/US/en/services/custom-products/custom-media-development-services) - [Custom Nucleic Acids](https://www.sigmaaldrich.com/US/en/products/molecular-biology-and-functional-genomics/oligos-and-qpcr-probes) - [Custom SPE Tubes & 96-Well Plates](https://www.sigmaaldrich.com/US/en/services/custom-products/custom-spe-tubes-and-96-well-plates) - [Custom SPME Fibers](https://www.sigmaaldrich.com/US/en/services/custom-products/custom-spme-fibers) - [Custom Test Strips & Papers](https://www.sigmaaldrich.com/US/en/services/custom-products/custom-test-strips-and-papers) - [Diagnostic OEM & CMO Services](https://www.sigmaaldrich.com/US/en/services/ivd-development-manufacturing/diagnostic-oem-cmo) - [Eshmuno^® Fit Custom Affinity Resin Development Services](https://www.sigmaaldrich.com/US/en/services/custom-products/eshmuno-fit-custom-affinity-resin-development-services) - [Production-Scale Materials & Custom Services](https://www.sigmaaldrich.com/US/en/services/custom-products/bulk-and-custom-services) - [Large-Volume Products Supply-Chain](https://www.sigmaaldrich.com/US/en/services/custom-products/bulk-and-custom-services/large-volume-products-supply-chain) - [Scalable Manufacturing & Custom Packaging](https://www.sigmaaldrich.com/US/en/services/custom-products/bulk-and-custom-services/scalable-manufacturing-and-custom-packaging) - [Reference Materials](https://www.sigmaaldrich.com/US/en/services/custom-products/reference-materials) - [Small Molecule Library Design (Aldrich Market Select)](https://www.sigmaaldrich.com/US/en/services/custom-products/small-molecule-library-design) - [Stable Isotope Custom & GMP Products](https://www.sigmaaldrich.com/US/en/services/custom-products/stable-isotope-custom-and-gmp-products) - [Digital Solutions for Life Science](https://www.sigmaaldrich.com/US/en/services/software-and-digital-platforms) - [AIDDISON™ AI-Powered Drug Discovery Software](https://www.sigmaaldrich.com/US/en/services/software-and-digital-platforms/aiddison-ai-powered-drug-discovery) - [Belysa^® Immunoassay Curve Fitting Software](https://www.sigmaaldrich.com/US/en/services/software-and-digital-platforms/belysa-immunoassay-curve-fitting-software) - [Bioprocessing Automation and Control Software](https://www.sigmaaldrich.com/US/en/integrated-offerings/biopharma-4-0/bioprocessing-automation-control-software) - [Bioprocessing Data Analytics Software](https://www.sigmaaldrich.com/US/en/integrated-offerings/biopharma-4-0/bioprocessing-data-analytics-software) - [Catalexis Catalysts Screening Platform](https://www.sigmaaldrich.com/US/en/services/software-and-digital-platforms/catalexis-catalyst-screening-platform) - [Chemistwin^® Digital Reference Materials](https://www.sigmaaldrich.com/US/en/services/software-and-digital-platforms/digital-reference-materials) - [DEL Extended Digital Service](https://www.sigmaaldrich.com/US/en/services/software-and-digital-platforms/dna-encoded-library-technology-drug-discovery) - [DOZN™ Tool](https://www.sigmaaldrich.com/US/en/services/software-and-digital-platforms/dozn-tool) - [mConfig™ Cell Culture Media and Chemicals Configurator](https://www.sigmaaldrich.com/US/en/services/software-and-digital-platforms/mconfig-cell-culture-media-chemicals-configurator) - [M-Trace^® Electronic Test Record Software](https://www.sigmaaldrich.com/US/en/services/software-and-digital-platforms/m-trace-electronic-test-record-software) - [Millicell^® Cloud Services](https://www.sigmaaldrich.com/US/en/services/software-and-digital-platforms/millicell-cloud-services) - [MQuant^® StripScan](https://www.sigmaaldrich.com/US/en/services/software-and-digital-platforms/mquant-stripscan) - [MyMilli-Q^™ Digital Services](https://www.sigmaaldrich.com/US/en/services/software-and-digital-platforms/mymilli-q-digital-services) - [SYNTHIA^™ Retrosynthesis Software](https://www.sigmaaldrich.com/US/en/services/software-and-digital-platforms/synthia-retrosynthesis-software) - [Val@M™ Application for Validation Activites](https://www.sigmaaldrich.com/US/en/services/software-and-digital-platforms/valatm-validation-platform) - [IVD Development & Manufacturing](https://www.sigmaaldrich.com/US/en/services/ivd-development-manufacturing) - [Custom Diagnostic Antibody Development & Manufacturing Services](https://www.sigmaaldrich.com/US/en/services/ivd-development-manufacturing/custom-diagnostic-antibody-development-and-manufacturing-services) - [Diagnostic OEM & CMO Services](https://www.sigmaaldrich.com/US/en/services/ivd-development-manufacturing/diagnostic-oem-cmo) - [Lateral Flow Assay Development Services](https://www.sigmaaldrich.com/US/en/services/ivd-development-manufacturing/lateral-flow-services) - [Product Services](https://www.sigmaaldrich.com/US/en/services/product-services) - [Application Services for Solid Dose Formulations](https://www.sigmaaldrich.com/US/en/services/product-services/application-services-solid-dose-formulations) - [Calibration & Verification](https://www.sigmaaldrich.com/US/en/services/product-services/calibration-and-verification) - [Milli-Q^® Calibration & Verification](https://www.sigmaaldrich.com/US/en/services/product-services/calibration-and-verification/calibration-verification-suitability-testing-of-milli-q-water-pu) - [Microbiology Testing Systems](https://www.sigmaaldrich.com/US/en/services/product-services/calibration-and-verification/calibration-verification-microbiology) - [Elevate Program](https://www.sigmaaldrich.com/US/en/services/product-services/elevate-quality-program) - [eMERGE™ Program](https://www.sigmaaldrich.com/US/en/services/product-services/the-emerge-standard-edata-exchange-platform) - [Emprove^® Program](https://www.sigmaaldrich.com/US/en/services/product-services/emprove-program) - [Emprove^® Cell Culture Media](https://www.sigmaaldrich.com/US/en/services/product-services/emprove-program/emprove-cell-culture-media) - [Emprove^® Chemicals Portfolio](https://www.sigmaaldrich.com/US/en/services/product-services/emprove-program/emprove-chemicals-portfolio) - [Emprove^® Chromatography Portfolio](https://www.sigmaaldrich.com/US/en/services/product-services/emprove-program/emprove-chromatography-portfolio) - [Emprove^® Filter and Single-Use Component Portfolio](https://www.sigmaaldrich.com/US/en/services/product-services/emprove-program/emprove-filter-and-single-use-component-portfolio) - [Emprove^® Suite](https://www.sigmaaldrich.com/US/en/services/product-services/emprove-program/emprove-suite) - [Maintenance & Service Plans](https://www.sigmaaldrich.com/US/en/services/product-services/maintenance-and-service-plans) - [Microbiology Testing Systems](https://www.sigmaaldrich.com/US/en/services/product-services/maintenance-and-service-plans/microbiology-maintenance-and-service-plans) - [Milli-Q^® Maintenance & Service Plans](https://www.sigmaaldrich.com/US/en/services/product-services/maintenance-and-service-plans/milli-q-services-plans-and-maintenance-for-water-purification-sy) - [Spectroquant^® Photometer Services](https://www.sigmaaldrich.com/US/en/services/product-services/maintenance-and-service-plans/spectroquant-photometer-services) - [System Service Reliance Plans](https://www.sigmaaldrich.com/US/en/services/product-services/maintenance-and-service-plans/system-service-reliance-plans) - [Milli-Q^® Services & Support](https://www.sigmaaldrich.com/US/en/services/product-services/milli-q-services-and-support) - [Maintenance & Service Plans](https://www.sigmaaldrich.com/US/en/services/product-services/maintenance-and-service-plans/milli-q-services-plans-and-maintenance-for-water-purification-sy) - [Qualification & Validation](https://www.sigmaaldrich.com/US/en/services/product-services/systems-qualification/milliq-qualification-program) - [Calibration & Verification](https://www.sigmaaldrich.com/US/en/services/product-services/calibration-and-verification/calibration-verification-suitability-testing-of-milli-q-water-pu) - [Additional Services](https://www.sigmaaldrich.com/US/en/services/product-services/milli-q-services-and-support/milli-q-additional-services) - [MyMilli-Q™ Digital Services](https://www.sigmaaldrich.com/US/en/services/software-and-digital-platforms/mymilli-q-digital-services) - [mPredict™ Co-Crystal Prediction Service](https://www.sigmaaldrich.com/US/en/services/product-services/m-predict-co-crystal-prediction-service) - [Single-Use & Filter Validation Services](https://www.sigmaaldrich.com/US/en/services/product-services/single-use-filter-validation) - [Bacterial Retention​ Testing](https://www.sigmaaldrich.com/US/en/services/product-services/single-use-filter-validation/bacterial-retention) - [Chemical Compatibility​ Testing](https://www.sigmaaldrich.com/US/en/services/product-services/single-use-filter-validation/chemical-compatibility) - [Extractables & Leachables​](https://www.sigmaaldrich.com/US/en/services/product-services/single-use-filter-validation/extractables-and-leachables) - [Filter Integrity Testing​](https://www.sigmaaldrich.com/US/en/services/product-services/single-use-filter-validation/integrity-testing) - [Validation Service Levels](https://www.sigmaaldrich.com/US/en/services/product-services/single-use-filter-validation/validation-service-levels) - [Validation Services Consultancy​](https://www.sigmaaldrich.com/US/en/services/product-services/single-use-filter-validation/validation-services-consultancy) - [Systems & Equipment Installation](https://www.sigmaaldrich.com/US/en/services/product-services/systems-and-equipment-installation) - [Bioprocessing Systems Equipment Installation](https://www.sigmaaldrich.com/US/en/services/product-services/systems-and-equipment-installation/bioprocessing-systems-equipment) - [Bioprocessing System Training & Specialized Services](https://www.sigmaaldrich.com/US/en/services/product-services/systems-and-equipment-installation/bioprocessing-systems-training) - [Microbiology Testing Systems](https://www.sigmaaldrich.com/US/en/services/product-services/systems-and-equipment-installation/system-and-equipment-installation-microbiology-testing-systems) - [Systems Qualification](https://www.sigmaaldrich.com/US/en/services/product-services/systems-qualification) - [Bioprocessing Systems Qualification](https://www.sigmaaldrich.com/US/en/services/product-services/systems-qualification/bioprocessing-systems-qualification) - [Food & Beverages QC Systems Qualification](https://www.sigmaaldrich.com/US/en/services/product-services/systems-qualification/food-and-beverage-qc-systems-qualification) - [Milli-Q^® Qualification & Validation](https://www.sigmaaldrich.com/US/en/services/product-services/systems-qualification/milliq-qualification-program) - [Pharma QC Systems Qualification](https://www.sigmaaldrich.com/US/en/services/product-services/systems-qualification/pharma-qc-systems-qualification) - [Validation Services](https://www.sigmaaldrich.com/US/en/services/product-services/validation-services) - [Food & Beverage Microbiology Method Validation](https://www.sigmaaldrich.com/US/en/services/product-services/validation-services/food-and-beverage-microbiology-method-validation) - [Pharma Microbiology Method Development & Validation](https://www.sigmaaldrich.com/US/en/services/product-services/validation-services/pharma-microbiology-method-development-validation) - [Val@M™ Application for Validation Activites](https://www.sigmaaldrich.com/US/en/services/software-and-digital-platforms/valatm-validation-platform) - [Support](https://www.sigmaaldrich.com/US/en/services/support) - [Inventory Management](https://www.sigmaaldrich.com/US/en/services/support/inventory-management) - [M Lab™ Collaboration Centers](https://www.sigmaaldrich.com/US/en/services/support/mlab-collaboration-centers) - [Programs](https://www.sigmaaldrich.com/US/en/life-science/partnership-programs) - [Recycling](https://www.sigmaaldrich.com/US/en/services/support/recycling) - [Biopharma Recycling Program](https://www.sigmaaldrich.com/US/en/services/support/recycling/biopharma-recycling-program) - [Greener Cooler](https://www.sigmaaldrich.com/US/en/services/support/recycling/greener-cooler) - [Polystyrene Cooler Recycling](https://www.sigmaaldrich.com/US/en/services/support/recycling/polystyrene-cooler-return-program) - [Training & Education](https://www.sigmaaldrich.com/US/en/services/support/training-and-education) - Resources - [Documents](https://www.sigmaaldrich.com/US/en/documents-search?tab=coa) - [Certificates of Analysis (COA)](https://www.sigmaaldrich.com/US/en/documents-search?tab=coa) - [Safety Data Sheets (SDS)](https://www.sigmaaldrich.com/US/en/documents-search?tab=sds) - [Certificates of Quality (COQ)](https://www.sigmaaldrich.com/US/en/documents-search?tab=coq) - [Certificates of Origin (COO)](https://www.sigmaaldrich.com/US/en/documents-search?tab=coo) - [Learning Center](https://www.sigmaaldrich.com/US/en/life-science/learning-center) - Support - [Customer Support](https://www.sigmaaldrich.com/US/en/support/customer-support) - [Contact Us](https://www.sigmaaldrich.com/US/en/collections/offices) - [Get Site Smart](https://www.sigmaaldrich.com/US/en/life-science/ecommerce/website-update-info) - [FAQ](https://maestro.my.site.com/knowledgeportal/s/) - [Quality & Regulatory](https://www.sigmaaldrich.com/US/en/life-science/quality-and-regulatory-management) - [Calculators & Apps](https://www.sigmaaldrich.com/US/en/support/calculators-and-apps) - [Webinars](https://www.sigmaaldrich.com/US/en/collections/webinars)