Water-Soluble Fullerene Materials

By: Joe Porwoll, Material Matters 2009, 4.1, 1.

Dr. Michael Diener of TDA Research Inc., kindly suggested that we offer the pyrrolidine-derivatized C60 molecule with a tris acid functionality (Prod. No. 709085). This water-soluble material serves as a superoxide quencher,1 on account of the redox properties of the C60 moiety. It shows almost 100% improvement in the O2 - quenching activity, which is measured by the decreased levels in reduction of cytochrome c by O2 -, (IC50 = 103.4 μM) over analogous water-soluble C60 molecules (IC50 ~ 200 μM).2 Fullerene-based compounds therefore have the potential to be patent antioxidants to protect against oxidative stress.3 These materials are expected to play a major part in the fight against Alzheimer’s, Parkinson’s, AIDS and many other diseases in which oxidation mechanisms play major roles.

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  1. Okuda, K.; Hirota, T.; Hirobe, M.; Nagano, T.; Mochizuki, M.; Mashino, T. Fullerene. Sci. Technol. 2000, 8, 89-104.
  2. Sun, T.; Xu, Z. Bioorg. Med. Chem. Lett. 2006, 16, 3731-3734.
  3. Lin, A. M. Y.; Chyi, B. Y.; Wang, S. D.; Yu, H.-H.; Kanakamma, P. P.; Lu, T.-Y.; Chou, C. K.; Ho, L. T. J. Neurochem. 1999, 72,1634-40.

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