[Skip to Content](https://www.sigmaaldrich.com#main-content) [![MilliporeSigma](https://www.sigmaaldrich.com/static/logos/purple/millipore_sigma.svg)](https://www.sigmaaldrich.com/US/en) Products Cart0 USEN Products ProductsApplicationsServicesResourcesSupport [Login / Register](https://www.sigmaaldrich.com/oidc-sign-in) [Order Lookup](https://www.sigmaaldrich.com/US/en/order-lookup) [Quick Order](https://www.sigmaaldrich.com/US/en/quick-order) Cart0 [Home](https://www.sigmaaldrich.com/US/en)[Cross-Coupling](https://www.sigmaaldrich.com/US/en/applications/chemistry-and-synthesis/synthetic-methods/cross-coupling)Jamison Nickel (II) Precatalysts # Jamison Nickel (II) Precatalysts ## Introduction Nickel catalysis has broad synthetic utility. However, the dearth of bench-stable nickel(0) sources and high catalyst loadings have limited its use.1 The Jamison group has developed a library of bench-stable phosphine-containing nickel(II) precatalysts that are converted into active catalysts *in situ*.2,3 ![Nickel catalysis has broad synthetic utility](https://www.sigmaaldrich.com/content/dam/cms-commons/sigmaaldrich/marketing/global/images/technical-documents/articles/chemistry-and-synthesis/cross-coupling/jamison-spotlight-2.jpg "Nickel catalysis has broad synthetic utility") __Figure 1.__Nickel catalysis has broad synthetic utility ## Advantages - Air- and water-stable - Converted to the active catalyst *in situ* - Can be used under ambient conditions – glovebox not necessary ![Representative Application](https://www.sigmaaldrich.com/content/dam/cms-commons/sigmaaldrich/marketing/global/images/technical-documents/articles/chemistry-and-synthesis/cross-coupling/jamison-spotlight-1.jpg "Representative Application") __Figure 2.__Representative Application2 ## Materials Sorry, an unexpected error has occurred Response not successful: Received status code 500 ### References 1\. Tasker SZ, Standley EA, Jamison TF. 2014. Recent advances in homogeneous nickel catalysis. Nature. 509(7500):299-309. [https://doi.org/10.1038/nature13274](https://doi.org/10.1038/nature13274) 2\. Standley EA, Jamison TF. 2013. Simplifying Nickel(0) Catalysis: An Air-Stable Nickel Precatalyst for the Internally Selective Benzylation of Terminal Alkenes. J. Am. Chem. Soc.. 135(4):1585-1592. [https://doi.org/10.1021/ja3116718](https://doi.org/10.1021/ja3116718) 3\. Standley EA, Smith SJ, Müller P, Jamison TF. 2014. A Broadly Applicable Strategy for Entry into Homogeneous Nickel(0) Catalysts from Air-Stable Nickel(II) Complexes. Organometallics. 33(8):2012-2018. [https://doi.org/10.1021/om500156q](https://doi.org/10.1021/om500156q) __Related Articles__ - [Jørgensen’s Organocatalysts](https://www.sigmaaldrich.com/US/en/technical-documents/technical-article/chemistry-and-synthesis/ch-functionalization/jorgensen-organocatalysts) - [MCAT- 53™ Catalyst for Ruthenium Formation](https://www.sigmaaldrich.com/US/en/technical-documents/technical-article/chemistry-and-synthesis/ch-functionalization/mcat-53-green-ruthenium-catalyst) - [Role of High Purity Metal Salts in Chemical Synthesis](https://www.sigmaaldrich.com/US/en/technical-documents/technical-article/chemistry-and-synthesis/ch-functionalization/role-of-high-purity-metal-salts-in-chemical-synthesis) - [Reductive amination with 2-picoline-borane complex](https://www.sigmaaldrich.com/US/en/technical-documents/technical-article/chemistry-and-synthesis/cross-coupling/2-picoline-borane) - [2nd Generation Buchwald Precatalysts](https://www.sigmaaldrich.com/US/en/technical-documents/technical-article/chemistry-and-synthesis/cross-coupling/2nd-generation-buchwald-precatalysts) - [MeOBIPHEP](https://www.sigmaaldrich.com/US/en/technical-documents/technical-article/chemistry-and-synthesis/cross-coupling/MeOBIPHEP) - [An Introduction to A-Phos, its Applications and Advantages](https://www.sigmaaldrich.com/US/en/technical-documents/technical-article/chemistry-and-synthesis/cross-coupling/a-phos) - [Trialkylphosphine for MBH Reactions](https://www.sigmaaldrich.com/US/en/technical-documents/technical-article/chemistry-and-synthesis/cross-coupling/air-stable-trialkylphosphine) - [View More](https://www.sigmaaldrich.com/US/en/search/facet-search?focus=sitecontent&term=facet-search) __Related Product Categories__ - [Inorganic Catalysts](https://www.sigmaaldrich.com/US/en/products/chemistry-and-biochemicals/catalysts/inorganic-catalysts) Top __Sign In To Continue__ To continue reading please sign in or create an account. Sign In__Don't Have An Account?__Register Support[Customer Support](https://www.sigmaaldrich.com/US/en/support/customer-support)[Contact Us](https://www.sigmaaldrich.com/US/en/collections/offices)[FAQ](https://maestro.my.site.com/knowledgeportal/s/)[Safety Data Sheets (SDS)](https://www.sigmaaldrich.com/US/en/documents-search?tab=sds)[Certificates (COA/COO)](https://www.sigmaaldrich.com/US/en/documents-search?tab=coa)[Quality & Regulatory](https://www.sigmaaldrich.com/US/en/life-science/quality-and-regulatory-management)[Calculators & Apps](https://www.sigmaaldrich.com/US/en/support/calculators-and-apps)[Webinars](https://www.sigmaaldrich.com/US/en/collections/webinars) Orders[Order Lookup](https://www.sigmaaldrich.com/US/en/order-lookup)[Quick Order](https://www.sigmaaldrich.com/US/en/quick-order)[Custom Products](https://www.sigmaaldrich.com/US/en/services/custom-products)[eCommerce Solutions](https://www.sigmaaldrich.com/US/en/life-science/ecommerce/ecommerce-solutions) Company[About Us](https://www.sigmaaldrich.com/US/en/life-science/about-us)[Responsibility](https://www.sigmaaldrich.com/US/en/life-science/ssbi)[Events](https://www.sigmaaldrich.com/US/en/collections/events)[Press Releases](https://www.sigmaaldrich.com/US/en/collections/press)[Programs](https://www.sigmaaldrich.com/US/en/life-science/partnership-programs)[Careers](https://careers.merckgroup.com/global/en)[Offices](https://www.sigmaaldrich.com/US/en/collections/offices) Social Media [![LinkedIn icon](https://www.sigmaaldrich.com/content/dam/cms-commons/sigmaaldrich/marketing/global/images/icons/linkedin.svg)](https://www.linkedin.com/company/merck-life-science) [![X icon](https://www.sigmaaldrich.com/content/dam/cms-commons/sigmaaldrich/marketing/global/images/icons/x-icon.svg)](https://x.com/Merck_lifesci) [![Facebook Icon](https://www.sigmaaldrich.com/content/dam/cms-commons/sigmaaldrich/marketing/global/images/icons/facebook.svg)](https://www.facebook.com/Merck.lifescience) [![Instagram Icon](https://www.sigmaaldrich.com/content/dam/cms-commons/sigmaaldrich/marketing/global/images/icons/instagram.svg)](https://www.instagram.com/mercklifescience/) [![YouTube Icon](https://www.sigmaaldrich.com/content/dam/cms-commons/sigmaaldrich/marketing/global/images/icons/youtube.svg)](https://www.youtube.com/@MerckLifeScience/featured) MilliporeSigma __Research. Development. Production.__ We are a leading supplier to the global Life Science industry with solutions and services for research, biotechnology development and production, and pharmaceutical drug therapy development and production. [![Vibrant M string](https://www.sigmaaldrich.com/content/dam/cms-commons/sigmaaldrich/marketing/global/images/icons/vibrant-m-string-1-rrvcrp.svg)](https://www.sigmaaldrich.com/US/en) [Sigma-Aldrich® Solutions](https://www.sigmaaldrich.com/US/en/life-science/sigma-aldrich)[BioReliance® Solutions](https://www.sigmaaldrich.com/US/en/life-science/bioreliance)[Millipore® Solutions](https://www.sigmaaldrich.com/US/en/life-science/millipore)[SAFC® Solutions](https://www.sigmaaldrich.com/US/en/life-science/safc)[Milli-Q® Solutions](https://www.sigmaaldrich.com/US/en/life-science/milliq)[Supelco® Solutions](https://www.sigmaaldrich.com/US/en/life-science/supelco) © 2026 Merck KGaA, Darmstadt, Germany and/or its affiliates. All Rights Reserved, including Text and Data Mining for AI training and similar technologies. Reproduction of any materials from the site is strictly forbidden without permission. [Site Use Terms](https://www.sigmaaldrich.com/US/en/life-science/legal/site-use-terms)|[Privacy Policy](https://www.sigmaaldrich.com/US/en/life-science/legal/privacy-statement)|[General Terms and Conditions of Sale](https://www.sigmaaldrich.com/US/en/life-science/legal/terms-and-conditions)|[Copyright Consent](https://www.sigmaaldrich.com/US/en/life-science/legal/copyright-consent) |[Site Map](https://www.sigmaaldrich.com/US/en/site-map) An unknown error has occured.