Jamison Nickel (II) Precatalysts

Introduction

Nickel catalysis has broad synthetic utility. However, the dearth of bench-stable nickel(0) sources and high catalyst loadings have limited its use.1 The Jamison group has developed a library of bench-stable phosphine-containing nickel(II) precatalysts that are converted into active catalysts in situ.2,3

Nickel catalysis has broad synthetic utility

 

Advantages

  • Air- and water-stable
  • Converted to the active catalyst in situ
  • Can be used under ambient conditions – glovebox not necessary

Representative Application2

Representative Application2

Materials

     

References

  1. Tasker, S. Z.; Standley, E. A.; Jamison, T. F. Nature 2014, 509, 299–309.
  2. Standley E. A.; Jamison, T. F. J. Am. Chem. Soc. 2013, 135, 1585–1592.
  3. Standley, E. A.; Smith, S. J.; Müller, P.; Jamison, T. F. Organometallics 2014, 33, 2012–2018.