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[Home](https://www.sigmaaldrich.com/US/en)[MILLIPLEX® Multiplex Assays for Luminex® Instruments](https://www.sigmaaldrich.com/US/en/products/protein-biology/immunoassay-platform-solutions/milliplex-multiplex-assays-for-luminex-technology)Neuroscience Multiplex Assays: Make More Connections in Neuroscience Research
# Neuroscience Multiplex Assays: Make More Connections in Neuroscience Research
__Section Overview__
- [What Are Biomarkers of Neurological Disorders?](https://www.sigmaaldrich.com#biomakers)
- [Neuroscience Multiplex Assays](https://www.sigmaaldrich.com#neuroscience)
- [Related Products](https://www.sigmaaldrich.com#products)
- [Related Webinars](https://www.sigmaaldrich.com#webinars)
Researchers use neuroscience-related biomarkers to gain more insights into the nervous system. Neuroscience multiplex assays, such as MILLIPLEX® multiplex assays, provide a deeper understanding of the underlying processes of neurodegenerative diseases, neurological disorders, and neuropeptide/neurohormone signaling.
## [](https://www.sigmaaldrich.com)What Are Biomarkers of Neurological Disorders?
A biomarker of a neurological disorder is, by definition, differentially expressed between a normal subject’s nervous system and that of a subject bearing a neurological disorder. Traditionally, neuroscience biomarkers could only be detected after a subject already exhibits cognitive decline or other symptoms of disease. However, recently, sensitive assays have shown biomarkers to be present even in advance of other symptoms. Examples of neuroscience-related biomarkers are described in __Table 1__.
| | |
|-------------------------------------|------------------------------------------------------------------------------|
| Neuroscience Research Area | Associated Biomarkers |
| Neurodegenerative Disease | Apo E, sICAM-1, GDNF, Amyloid β40, sVCAM-1, sRAGE, Amyloid β42, PAI-1, S100B |
| Neurological Disorders | Tau, Park7, AGP, Phospho Tau, NGFβ, CP, Park5, NSE, SAP |
| Neuropeptide/Neurohormone Signaling | α-MSH, Cortisol, Melatonin, Orexin A, Oxytocin, Substance P |
Table 1.Examples of common neuroscience biomarkers.
## [](https://www.sigmaaldrich.com)Neuroscience Multiplex Assays
No single biomarker has the power to give researchers a complete picture of nervous system functions such as perception, cognition, motor, and homeostatic control, or of disorders such as Alzheimer’s and Parkinson’s disease, multiple sclerosis, and amyotrophic lateral sclerosis (ALS). Neuroscience multiplex assays, such as bead-based MILLIPLEX® neuroscience multiplex immunoassays, using trusted Luminex® xMAP® technology, enable a multivariate analysis of the processes that underlie neural development, homeostasis, and pathogenesis—all while conserving precious samples.
MILLIPLEX® multiplex assays enable you to simultaneously measure neuroscience-related biomarkers to gain a better picture of neurodegenerative diseases, neurological disorders, and neuropeptide/neurohormone signaling.
For example, MILLIPLEX® neuroscience assays have been used to:
- [](https://www.sigmaaldrich.com)[](https://www.sigmaaldrich.com)[Detect Amyloid β 1-40 and 1-42 and total and phospho-Tau (Thr181)](https://www.sigmaaldrich.com/US/en/technical-documents/product-supporting/milliplex/multiplex-detection-of-alzheimers-disease-biomarkers) in Alzheimer’s disease research
- Dive deeper into Alzheimer’s disease research by [combining multiplexing results with ultrasensitive immunoassays](https://www.sigmaaldrich.com/US/en/technical-documents/product-supporting/smc-technologies/multiplex-high-sensitivity-immunoassay-detection-of-ad-biomarkers)
- [Understand the inflammatory response to stroke](https://www.selectscience.net/editorial-articles/understanding-the-inflammatory-response-to-stroke-in-the-human-brain-through-mouse-models/?artID=42890) in the brain through mouse models
- Combine learnings from stroke and Alzheimer’s disease research to [further understanding of mixed dementia](https://www.selectscience.net/editorial-articles/husband-and-wife-duo-combating-dementia-through-neurological-research?artID=43211)
## [](https://www.sigmaaldrich.com)Related Products
Explore our MILLIPLEX® neuroscience multiplex assays.
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__For Research Use Only. Not For Use In Diagnostic Procedures.__
[Request info on MILLIPLEX® assays](https://www.sigmaaldrich.com/US/en/campaigns/milliplex-request-info)
## [](https://www.sigmaaldrich.com)Related Webinars
See how researchers are using MILLIPLEX® neuroscience assays in the webinar below.
[Multiplex Immunoassay Detection of Alzheimer’s Disease Biomarkers](https://www.sigmaaldrich.com/US/en/collections/webinars/w143562783)
__Related Articles__
- [Integrating Multiplex and High Sensitivity Immunoassay Detection of Alzheimer’s Disease Biomarkers](https://www.sigmaaldrich.com/US/en/technical-documents/product-supporting/smc-technologies/multiplex-high-sensitivity-immunoassay-detection-of-ad-biomarkers)
- [How High Sensitivity Immunoassays Expand Neuroscience Research | SMC® Technology](https://www.sigmaaldrich.com/US/en/technical-documents/product-supporting/smc-technologies/how-high-sensitivity-immunoassays-expand-neuroscience-research)
- [384- vs. 96-Well Multiplex Analysis of Low-Level Cytokines | MILLIPLEX® Assays](https://www.sigmaaldrich.com/US/en/technical-documents/product-supporting/milliplex/384-vs-96-well-multiplex-analysis-of-low-level-cytokines)
- [Quality in MILLIPLEX® Multiplex Kits](https://www.sigmaaldrich.com/US/en/technical-documents/product-supporting/milliplex/quality-in-milliplex-multiplex-kits)
- [Luminex® Multiplexing Platforms Comparison](https://www.sigmaaldrich.com/US/en/technical-documents/product-supporting/milliplex/luminex-multiplexing-platforms-comparison)
- [Multiplex Detection with the xMAP® INTELLIFLEX® System](https://www.sigmaaldrich.com/US/en/technical-documents/product-supporting/milliplex/multiplex-detection-with-the-xmap-intelliflex-system)
- [How to Automate MILLIPLEX® Multiplex Human Panel A on the AAW™ Workstation](https://www.sigmaaldrich.com/US/en/technical-documents/product-supporting/aaw-automated-assay-workstation/automating-milliplex-human-panel-a-assay)
- [BioTek® Multiplexing Microplate Washers | MILLIPLEX® Assays](https://www.sigmaaldrich.com/US/en/technical-documents/product-supporting/milliplex/biotek-multiplexing-microplate-washers)
- [View More](https://www.sigmaaldrich.com/US/en/search/facet-search?focus=sitecontent&term=facet-search)
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