[Skip to Content](https://www.sigmaaldrich.com#main-content) [](https://www.sigmaaldrich.com/US/en) Products Cart0 USEN Products ProductsApplicationsServicesResourcesSupport [Login / Register](https://www.sigmaaldrich.com/oidc-sign-in) [Order Lookup](https://www.sigmaaldrich.com/US/en/order-lookup) [Quick Order](https://www.sigmaaldrich.com/US/en/quick-order) Cart0 [Home](https://www.sigmaaldrich.com/US/en)[QuEChERS Sample Preparation Method](https://www.sigmaaldrich.com/US/en/applications/analytical-chemistry/sample-preparation/quechers)Supel™ QuE Z-Sep Sorbents for QuEChERS # Supel™ QuE Z-Sep Sorbents for QuEChERS Supel™ QuE Z-Sep sorbents enhance sample cleanup for complex matrices by effectively removing more fat and color from sample extracts than traditional phases for QuEChERS. By eliminating problematic matrix interferences, Z-Sep products provide more robust LC-MS and GC-MS methods. This proprietary technology can replace C18 and PSA phases in your current methods without additional method development. Supel™ QuE Z-Sep/C18, a combination of Discovery® DSC-18 and Z-Sep particles, is recommended for samples containing <15% fat. Supel QuE Z-Sep+, C18 and Z-Sep dual bonded to silica, is recommended for cleanup of samples containing >15% fat. Supel QuE Z-Sep is recommended for the anlysis of hydrophobic analytes in fatty matrices. [Download Our Supel™ QuE QuEChERS Brochure](https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/282/118/supel-que-sample-preparation-brochure-br4167en-mk.pdf) ## Related products Sorry, an unexpected error has occurred Response not successful: Received status code 500 ### References 1\. Rajski Ł, Lozano A, Uclés A, Ferrer C, Fernández-Alba AR. 2013. Determination of pesticide residues in high oil vegetal commodities by using various multi-residue methods and clean-ups followed by liquid chromatography tandem mass spectrometry. Journal of Chromatography A. 1304109-120. [https://doi.org/10.1016/j.chroma.2013.06.070](https://doi.org/10.1016/j.chroma.2013.06.070) 2\. Sapozhnikova Y, Lehotay SJ. 2013. Multi-class, multi-residue analysis of pesticides, polychlorinated biphenyls, polycyclic aromatic hydrocarbons, polybrominated diphenyl ethers and novel flame retardants in fish using fast, low-pressure gas chromatography?tandem mass spectrometry. Analytica Chimica Acta. 75880-92. [https://doi.org/10.1016/j.aca.2012.10.034](https://doi.org/10.1016/j.aca.2012.10.034) 3\. Geis-Asteggiante L, Lehotay SJ, Lightfield AR, Dutko T, Ng C, Bluhm L. 2012. Ruggedness testing and validation of a practical analytical method for >100 veterinary drug residues in bovine muscle by ultrahigh performance liquid chromatography?tandem mass spectrometry. Journal of Chromatography A. 125843-54. [https://doi.org/10.1016/j.chroma.2012.08.020](https://doi.org/10.1016/j.chroma.2012.08.020) __Related Articles__ - [QuEChERS Method for Pesticide Residue Analysis](https://www.sigmaaldrich.com/US/en/technical-documents/protocol/analytical-chemistry/quechers/quechers-method-pesticide-residue-analysis) - [Pesticide Residue Analysis in Ginger Powder with QuEChERS](https://www.sigmaaldrich.com/US/en/technical-documents/technical-article/analytical-chemistry/quechers/analysis-of-pesticide-residues-in-ginger-powder) - [Analysis of Pesticide Residues in Pistachios Using QuEChERS Extraction and Cleanup with Supel™ QuE Z-Sep+](https://www.sigmaaldrich.com/US/en/technical-documents/technical-article/analytical-chemistry/quechers/analysis-of-pesticide-residues-in-pistachios) - [Comparison of QuEChERS Products for the Extraction of Planar Pesticides from Spinach](https://www.sigmaaldrich.com/US/en/technical-documents/technical-article/analytical-chemistry/quechers/planar-pesticides-spinach) - [Cannabinoids Analysis Workflow with Chromolith® Column](https://www.sigmaaldrich.com/US/en/technical-documents/technical-article/environmental-testing-and-industrial-hygiene/cannabis-testing/cannabis-potency-testing/cannabinoids-analysis-in-cannabis-using-chromolith-monolithic-silica-hplc-column) - [LC-MS/MS Analysis of 16 PFAS in Salmon Using QuEChERS Based on FDA Method C-010.02](https://www.sigmaaldrich.com/US/en/technical-documents/technical-article/food-and-beverage-testing-and-manufacturing/chemical-analysis-for-food-and-beverage/lc-ms-ms-analysis-of-16-pfas-in-salmon-using-quechers) - [LC-MS/MS Analysis of 16 Per- and Polyfluoroalkyl Substances (PFAS) in Milk Using QuEChERS Based on FDA Method C-010.02](https://www.sigmaaldrich.com/US/en/technical-documents/technical-article/food-and-beverage-testing-and-manufacturing/chemical-analysis-for-food-and-beverage/pfas-analysis-in-milk) Top __Sign In To Continue__ To continue reading please sign in or create an account. Sign In__Don't Have An Account?__Register Support[Customer Support](https://www.sigmaaldrich.com/US/en/support/customer-support)[Contact Us](https://www.sigmaaldrich.com/US/en/collections/offices)[FAQ](https://maestro.my.site.com/knowledgeportal/s/)[Safety Data Sheets (SDS)](https://www.sigmaaldrich.com/US/en/documents-search?tab=sds)[Certificates (COA/COO)](https://www.sigmaaldrich.com/US/en/documents-search?tab=coa)[Quality & Regulatory](https://www.sigmaaldrich.com/US/en/life-science/quality-and-regulatory-management)[Calculators & Apps](https://www.sigmaaldrich.com/US/en/support/calculators-and-apps)[Webinars](https://www.sigmaaldrich.com/US/en/collections/webinars) Orders[Order Lookup](https://www.sigmaaldrich.com/US/en/order-lookup)[Quick Order](https://www.sigmaaldrich.com/US/en/quick-order)[Custom Products](https://www.sigmaaldrich.com/US/en/services/custom-products)[eCommerce Solutions](https://www.sigmaaldrich.com/US/en/life-science/ecommerce/ecommerce-solutions) Company[About Us](https://www.sigmaaldrich.com/US/en/life-science/about-us)[Responsibility](https://www.sigmaaldrich.com/US/en/life-science/ssbi)[Events](https://www.sigmaaldrich.com/US/en/collections/events)[Press Releases](https://www.sigmaaldrich.com/US/en/collections/press)[Programs](https://www.sigmaaldrich.com/US/en/life-science/partnership-programs)[Careers](https://careers.merckgroup.com/global/en)[Offices](https://www.sigmaaldrich.com/US/en/collections/offices) Social Media [](https://www.linkedin.com/company/merck-life-science) [](https://x.com/Merck_lifesci) [](https://www.facebook.com/Merck.lifescience) [](https://www.instagram.com/mercklifescience/) [](https://www.youtube.com/@MerckLifeScience/featured) MilliporeSigma __Research. Development. Production.__ We are a leading supplier to the global Life Science industry with solutions and services for research, biotechnology development and production, and pharmaceutical drug therapy development and production. [](https://www.sigmaaldrich.com/US/en) [Sigma-Aldrich® Solutions](https://www.sigmaaldrich.com/US/en/life-science/sigma-aldrich)[BioReliance® Solutions](https://www.sigmaaldrich.com/US/en/life-science/bioreliance)[Millipore® Solutions](https://www.sigmaaldrich.com/US/en/life-science/millipore)[SAFC® Solutions](https://www.sigmaaldrich.com/US/en/life-science/safc)[Milli-Q® Solutions](https://www.sigmaaldrich.com/US/en/life-science/milliq)[Supelco® Solutions](https://www.sigmaaldrich.com/US/en/life-science/supelco) © 2026 Merck KGaA, Darmstadt, Germany and/or its affiliates. All Rights Reserved, including Text and Data Mining for AI training and similar technologies. Reproduction of any materials from the site is strictly forbidden without permission. [Site Use Terms](https://www.sigmaaldrich.com/US/en/life-science/legal/site-use-terms)|[Privacy Policy](https://www.sigmaaldrich.com/US/en/life-science/legal/privacy-statement)|[General Terms and Conditions of Sale](https://www.sigmaaldrich.com/US/en/life-science/legal/terms-and-conditions)|[Copyright Consent](https://www.sigmaaldrich.com/US/en/life-science/legal/copyright-consent) |[Site Map](https://www.sigmaaldrich.com/US/en/site-map) An unknown error has occured.