Neurodegenerative Diseases: Peering in on Protein Interactions

As the population ages, neurodegenerative diseases are becoming increasingly prevalent. These diseases bear with them increased health-care costs, caretaker burden, and an urgent research need. Research into the mechanisms of the most prevalent neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis is ongoing, but the molecular underpinnings are still poorly defined. New methods are enabling the direct analysis of protein-protein interactions. These interactions are painting a clearer picture of the diseases’ mechanisms. The Scientist  drew together a panel of experts to share their experience bringing these methods to bear on complex neurodegenerative diseases.


Sophia Schedin Weiss, PhD
Associate Professor, Center for Alzheimer Research
Department of Neurobiology, Care Sciences and Society, Karolinska Institutet

Salvador Sierra-San Nicolás, MD, PhD
Postdoctoral Fellow, Department of Pharmacological Sciences
Icahn School of Medicine at Mount Sinai