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D0720000

Dexamethasone sodium phosphate

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

Dexamethasone 21-phosphate disodium salt

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About This Item

Empirical Formula (Hill Notation):
C22H28FNa2O8P
CAS Number:
2392-39-4
Molecular Weight:
516.40
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329798630
EC Number:
219-243-0
Beilstein/REAXYS Number:
6473066
MDL number:
MFCD00079105

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Product Name

Dexamethasone sodium phosphate, European Pharmacopoeia (EP) Reference Standard

InChI

1S/C22H30FO8P.2Na/c1-12-8-16-15-5-4-13-9-14(24)6-7-19(13,2)21(15,23)17(25)10-20(16,3)22(12,27)18(26)11-31-32(28,29)30;;/h6-7,9,12,15-17,25,27H,4-5,8,10-11H2,1-3H3,(H2,28,29,30);;/q;2*+1/p-2/t12-,15+,16+,17+,19+,20+,21+,22+;;/m1../s1

InChI key

PLCQGRYPOISRTQ-FCJDYXGNSA-L

SMILES string

[Na+].[Na+].[H][C@@]12CCC3=CC(=O)C=C[C@]3(C)[C@@]1(F)[C@@H](O)C[C@@]4(C)[C@@]2([H])C[C@@H](C)[C@]4(O)C(=O)COP([O-])([O-])=O

grade

pharmaceutical primary standard

API family

dexamethasone

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

Gene Information

human ... NR3C1(2908)

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Show Differences

1 of 4

This Item
1177032PHR1768BP108
Dexamethasone sodium phosphate European Pharmacopoeia (EP) Reference Standard

D0720000

Dexamethasone sodium phosphate

Dexamethasone sodium phosphate United States Pharmacopeia (USP) Reference Standard

USP

1177032

Dexamethasone sodium phosphate

Dexamethasone Sodium Phosphate Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1768

Dexamethasone Sodium Phosphate

Dexamethasone sodium phosphate British Pharmacopoeia (BP) Reference Standard

BP108

Dexamethasone sodium phosphate

manufacturer/tradename

EDQM

manufacturer/tradename

USP

manufacturer/tradename

-

manufacturer/tradename

BP

grade

pharmaceutical primary standard

grade

pharmaceutical primary standard

grade

certified reference material, pharmaceutical secondary standard

grade

pharmaceutical primary standard

format

neat

format

neat

format

neat

format

neat

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical
pharmaceutical small molecule

API family

dexamethasone

API family

dexamethasone

API family

dexamethasone

API family

dexamethasone

Gene Information

human ... NR3C1(2908)

Gene Information

human ... NR3C1(2908)

Gene Information

human ... NR3C1(2908)

Gene Information

human ... NR3C1(2908)

Application

Dexamethasone sodium phosphate EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Other Notes

Sales restrictions may apply.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

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PHR1526

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pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Repr. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Veysel Nijat Baş et al.
European journal of pediatrics, 171(4), 735-736 (2011-12-29)
Iatrogenic Cushing syndrome may occur as an undesirable outcome of high-dose glucocorticoids treatments. This may also cause hypothalamus-hypophysis-adrenal axis suppression. While this situation may be caused more frequently with oral and topical glucocorticoid therapy, iatrogenic Cushing syndrome in childhood, caused
Weina Liu et al.
Neuroscience letters, 524(2), 119-123 (2012-07-21)
Prenatal exposure to glucocorticoids (GCs) leads to affective dysfunction in adulthood, which may be associated with the alterations in hypothalamic-pituitary-adrenal (HPA) axis. Physical exercise has been shown to ameliorate depressive symptoms. The objectives of present study were to investigate whether
Martin Gräber et al.
ACS chemical biology, 6(10), 1008-1014 (2011-07-30)
Phosphorylation-dependent protein binding domains are crucially important for intracellular signaling pathways and thus highly relevant targets in chemical biology. By screening of chemical libraries against 12 structurally diverse phosphorylation-dependent protein binding domains, we have identified fosfosal and dexamethasone-21-phosphate as selective
Marieke Veurink et al.
Pharmaceutical research, 30(4), 1176-1187 (2013-02-16)
To investigate the mechanism behind the aggregation breaking properties of dexamethasone phosphate and related corticosteroids on the IgG1 antibody bevacizumab (Avastin®). An in silico 3D dimer model is developed to identify the bevacizumab-bevacizumab interface, and different corticosteroids are docked onto
Xiaolin Xu et al.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 249(10), 1503-1510 (2011-05-21)
To assess how safe and effective it is to use menthol as a permeability enhancer in ophthalmic drug delivery systems. In this study, the effect of menthol on permeability of dexamethasone disodium phosphate in the cornea and sclera was investigated
View All Related Papers

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