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Merck

14879

BIS-TRIS

BioUltra, ≥99.0% (NT)

Synonym(s):

2,2-Bis(hydroxymethyl)-2,2′,2″-nitrilotriethanol, 2-Bis(2-hydroxyethyl)amino-2-(hydroxymethyl)-1,3-propanediol, Bis(2-hydroxyethyl)amino-tris(hydroxymethyl)methane

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100 G

$331.00

$331.00

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About This Item

Empirical Formula (Hill Notation):
C8H19NO5
CAS Number:
6976-37-0
Molecular Weight:
209.24
Beilstein:
2205275
EC Number:
230-237-7
MDL number:
MFCD00002853
UNSPSC Code:
12161700
PubChem Substance ID:
57647226
NACRES:
NA.25

Key Documents

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product line

BioUltra

Quality Level

200

Assay

≥99.0% (NT)

form

powder

impurities

insoluble matter, passes filter test

ign. residue

≤0.3%

loss

≤0.5% loss on drying, 20 °C (HV)

pH

9.5-11.0 (25 °C, 1 M in H2O)

useful pH range

5.8-7.2

pKa (25 °C)

6.5

solubility

H2O: 1 M at 20 °C, clear, colorless

anion traces

chloride (Cl-): ≤50 mg/kg
sulfate (SO42-): ≤50 mg/kg

cation traces

Al: ≤5 mg/kg
As: ≤0.1 mg/kg
Ba: ≤5 mg/kg
Bi: ≤5 mg/kg
Ca: ≤10 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤5 mg/kg
K: ≤50 mg/kg
Li: ≤5 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Mo: ≤5 mg/kg
Na: ≤50 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Sr: ≤5 mg/kg
Zn: ≤5 mg/kg

absorption

cut-off at 270 nm in H2O at 1 M

λ

1 M in H2O

UV absorption

λ: 280 nm Amax: 0.1

SMILES string

OCCN(CCO)C(CO)(CO)CO

InChI

1S/C8H19NO5/c10-3-1-9(2-4-11)8(5-12,6-13)7-14/h10-14H,1-7H2

InChI key

OWMVSZAMULFTJU-UHFFFAOYSA-N

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Show Differences

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This Item
B7535B4429RDD013
BIS-TRIS BioUltra, ≥99.0% (NT)

Sigma-Aldrich

14879

BIS-TRIS

BIS-TRIS BioXtra, ≥98.0% (titration)

Sigma-Aldrich

B7535

BIS-TRIS

BIS-TRIS BioPerformance Certified, suitable for cell culture, suitable for insect cell culture, ≥98.0%

Sigma-Aldrich

B4429

BIS-TRIS

BIS-TRIS anhydrous, free-flowing, Redi-Dri™, ≥98.0%

Sigma-Aldrich

RDD013

BIS-TRIS

assay

≥99.0% (NT)

assay

≥98.0% (titration)

assay

≥98.0%

assay

≥98.0%

product line

BioUltra

product line

BioXtra

product line

-

product line

Redi-Dri™

Quality Level

200

Quality Level

400

Quality Level

400

Quality Level

100

form

powder

form

powder

form

crystalline powder

form

crystalline powder

solubility

H2O: 1 M at 20 °C, clear, colorless

solubility

H2O: 1 M, clear, colorless

solubility

H2O: 500 mg/mL, clear, colorless to very faintly yellow

solubility

water: 500 mg/mL, clear, colorless to faint yellow or tan

pH

9.5-11.0 (25 °C, 1 M in H2O)

pH

9.0-10.1 (20-25 °C, 1 M in H2O)

pH

-

pH

9.0-10.1 (20-25 °C, 1 M in water)

Application

BIS-TRIS can be used to study biological buffers. BIS-TRIS has been used in a study that synthesized ferritin grafted with temperature-responsive poly(N-isopropylacrylamide) (PIPAAm-ferritin) by a coupling reaction using PIPAAm and ferritin for obtaining stimuli-responsive biomaterials. BIS-TRIS has also been used in a study that synthesized and described the photochemical properties of oligo- ortho –azobenzenes.

Other Notes

Easily compare specifications for BIS-TRIS products with the BIS-TRIS specification table.
Effective buffer for the assay of creatine kinase[1]; Effectively protects hemoglobin during freeze-drying[2]; Catholyte in IEF of 2-D gel electrophoresis[3].
Effective buffer for the assay of creatine kinasecitation; Effectively protects hemoglobin during freeze-drying Catholyte in IEF of 2-D gel electrophoresis.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H319

Hazard Classifications

Eye Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCN5445
BCCN0191
BCCM4003
BCCH4368
BCCK2201

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Molecules related to Tris and some derivatives that protect haemoglobin during freeze-drying.
P Labrude et al.
The Journal of pharmacy and pharmacology, 32(4), 305-307 (1980-04-01)
J.A.A. Chambers et al.
Electrophoresis, 6, 339-339 (1985)
[Bis(2-hydroxyethyl)amino]tris(hydroxymethyl)methane is an effective buffer for creatine kinase assays.
D A Nealon et al.
Clinical chemistry, 26(10), 1516-1517 (1980-09-01)
Lesley Cheng et al.
Kidney international, 86(2), 433-444 (2013-12-20)
Micro RNAs (miRNAs) have been shown to circulate in biological fluids and are enclosed in vesicles such as exosomes; they are present in urine and represent a noninvasive methodology to detect biomarkers for diagnostic testing. The low abundance of RNA
Elizabeth M MacDonald et al.
Disease models & mechanisms, 7(4), 471-481 (2014-02-08)
The purpose of our study was to compare two acquired muscle atrophies and the use of myostatin inhibition for their treatment. Myostatin naturally inhibits skeletal muscle growth by binding to ActRIIB, a receptor on the cell surface of myofibers. Because
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