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A5285

Adenosine 5′-diphosphate monopotassium salt dihydrate

bacterial, ≥95%, P2Y receptor agonist, powder

Synonym(s):

Adenosine 5′-Diphosphate Potassium Salt, ADP

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About This Item

Empirical Formula (Hill Notation):
C10H14KN5O10P2 · 2H2O
CAS Number:
72696-48-1
Molecular Weight:
501.32
UNSPSC Code:
41106305
eCl@ss:
32160414
PubChem Substance ID:
24890964
NACRES:
NA.77
MDL number:
MFCD00066472

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Product Name

Adenosine 5′-diphosphate monopotassium salt dihydrate, bacterial, ≥95%, powder

SMILES string

[O-]P(OP(OC[C@H]([C@@H](O)[C@H]1O)O[C@H]1N2C3=C(N=C2)C(N)=NC=N3)(O)=O)(O)=O.[K+]

InChI

1S/C10H15N5O10P2.K/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20;/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20);/q;+1/p-1/t4-,6-,7-,10-;/m1./s1

InChI key

ZNCWUOPIJTUALR-MCDZGGTQSA-M

biological source

bacterial

assay

≥95%

form

powder

storage temp.

−20°C

Quality Level

200

Gene Information

human ... HSP90AA1(3320), P2RY1(5028)

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1 of 4

This Item
A2754A6885117105
Adenosine 5′-diphosphate monopotassium salt dihydrate bacterial, ≥95%, powder

Sigma-Aldrich

A5285

Adenosine 5′-diphosphate monopotassium salt dihydrate

Adenosine 5′-diphosphate sodium salt bacterial, ≥95% (HPLC)

Sigma-Aldrich

A2754

Adenosine 5′-diphosphate sodium salt

Adenosine 3′,5′-cyclic monophosphate sodium salt monohydrate ≥98.0% (HPLC), powder

Sigma-Aldrich

A6885

Adenosine 3′,5′-cyclic monophosphate sodium salt monohydrate

Adenosine 5′-diphosphate monopotassium salt dihydrate M.W. 501.3 (dihydrate).

Millipore

117105

Adenosine 5′-diphosphate monopotassium salt dihydrate

form

powder

form

powder

form

powder

form

solid

assay

≥95%

assay

≥95% (HPLC)

assay

≥98.0% (HPLC)

assay

≥98% dry basis (enzymatic)

Quality Level

200

Quality Level

300

Quality Level

200

Quality Level

100

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

biological source

bacterial

biological source

bacterial

biological source

-

biological source

-

Gene Information

human ... HSP90AA1(3320), P2RY1(5028)

Gene Information

human ... HSP90AA1(3320), P2RY1(5028)

Gene Information

-

Gene Information

-

Application

Adenosine 5′-diphosphate has been used to study the release, neuronal effects, and removal of extracellular β-nicotinamide adenine dinucleotide (β-NAD+) in the rat brain. Adenosine 5′-diphosphate has also been used to compare prasugrel versus clopidogrel antiplatelet therapy after acute coronary syndrome.
Adenosine 5′-diphosphate monopotassium salt dihydrate (ADP) has been used:
  • in titration to determine complex I-supported respiration in permeabilized muscle fibers[1]
  • in titrations to determine ADP-stimulated respiratory kinetics[2]
  • in the preparation of ADP solution for measuring mitochondrial respiration[3]

General description

Adenosine diphosphate (ADP) is a crucial component for energy flow in living organisms. Its structure consists of a sugar backbone connected to adenine and two phosphate groups attached to the fifth carbon atom of the ribose sugar. ADP serves a precursor for ATP biosynthesis.[4] ADP acts as a weak platelet agonist, specifically targeting the P2Y receptor. However, ADP plays a vital role in platelet function by enhancing the effects of other platelet agonists and promoting the stability of platelet aggregates when released from platelet dense granules.[5]

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000482998
0000482998
0000462150
0000462150
0000450506

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Protocol for Measurement of Oxygen Consumption Rate In Situ in Permeabilized Cardiomyocytes
Gao M, et al.
STAR protocols (2020)
Leonie Durnin et al.
The European journal of neuroscience, 35(3), 423-435 (2012-01-27)
Recent evidence supports an emerging role of β-nicotinamide adenine dinucleotide (β-NAD(+) ) as a novel neurotransmitter and neuromodulator in the peripheral nervous system -β-NAD(+) is released in nerve-smooth muscle preparations and adrenal chromaffin cells in a manner characteristic of a
Correction to: Altered mitochondrial bioenergetics and ultrastructure in the skeletal muscle of young adults with type 1 diabetes
Monaco CMF, et al.
Diabetologia (2020)
James E Tcheng et al.
American journal of cardiovascular drugs : drugs, devices, and other interventions, 12(2), 83-91 (2012-02-10)
Antithrombotic therapy is imperative in the management of patients presenting with an acute coronary syndrome (ACS). The combination of antiplatelet therapy in conjunction with antithrombotic therapy has become the standard of care in improving the morbidity and mortality of patients
The Platelet P2 Receptors
Cattaneo M
Platelets (2013)
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